Patent US4085117A successfully refreshed from Google Patents.
US4085117A
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6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids
Assignee: Merck and Co Inc
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Filing: 1976-10-18
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Granted: 1978-04-18
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Expires: 1996-10-18
Abstract
Abstract 6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids, the pharmaceutically acceptable salt, ester and amide derivatives thereof and combinations of these compounds with antikaluretic agents are disclosed having diuretic-saluretic, uricosuric and antihypertensive activity.
Inventors
- 👤 Edward J. Cragoe, Jr.
- 👤 Otto W. WOLTERSDORF, Jr.
- 👤 William F. Hoffman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:07
CPC Classifications
C; C07; C07C; C07C39/00; C07C39/24; C07C39/373; C07C39/18; C07C39/19; C07D; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D307/80; C07D307/82; C07D307/84; C07D307/85
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
41 words
A compound having the formula: ##STR7## wherein X is halo, methyl or hydrogen; Y is halo or methyl and R is thienyl or a substituted thienyl wherein the substituent is halo or methyl, and the non-toxic pharmaceutically acceptable salt derivative thereof.
Claim 2
Dependent Claim
41 words
A compound having the formula: ##STR7## wherein X is halo, methyl or hydrogen; Y is halo or methyl and R is thienyl or a substituted thienyl wherein the substituent is halo or methyl, and the non-toxic pharmaceutically acceptable salt derivative thereof.
Claim 3
Dependent Claim
11 words
A compound of claim 1 wherein X and Y are halo.
Claim 4
Dependent Claim
19 words
The compound of claim 1 wherein X and Y are chloro and R is 2-thienyl thus forming 6,7-dichloro-5-(2-thenoyl)benzofuran-2-carboxylic acid.
Claim 5
Dependent Claim
19 words
The compound of claim 1 wherein X and Y are methyl and R is 2-thienyl thus forming 6,7-dimethyl-5-(2-thenoyl)benzofuran-2-carboxylic acid.
Claim 6
Dependent Claim
21 words
The compound of claim 1 wherein X is hydrogen and Y is chloro, and R is 2-thienyl thus forming 6-chloro-5-(2-thenoyl)-benzofuran-2-carboxylic acid.
Claim 7
Dependent Claim
19 words
The compound of claim 1 wherein X and Y are chloro and R is 2-methylthienyl thus forming 6,7-dichloro-5-(5-methyl-2-thenoyl)benzofuran-2-carboxylic acid.
Claim 8
Dependent Claim
21 words
The compound of claim 1 wherein X is methyl and Y is chloro and R is 2-thienyl thus forming 6-chloro-7-methyl-5-(2-thenoyl)benzofuran-2-carboxylic acid.
Claim 9
Dependent Claim
38 words
A compound of the formula: ##STR8## wherein X is halo, methyl or hydrogen; Y is halo or methyl; R is selected from the group consisting of 2-thienyl, 3-thienyl or 5-methyl-2-thienyl and the non-toxic pharmaceutically acceptable salt derivatives thereof.
Claim 10
Dependent Claim
38 words
A compound of the formula: ##STR8## wherein X is halo, methyl or hydrogen; Y is halo or methyl; R is selected from the group consisting of 2-thienyl, 3-thienyl or 5-methyl-2-thienyl and the non-toxic pharmaceutically acceptable salt derivatives thereof.
Claim 11
Dependent Claim
12 words
The compound of claim 8 wherein X and Y are both chloro.
References Cited (Backward Citations)
US3479343A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-17 | 1981-10-17 | 1982-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-17 | 1985-10-17 | 1986-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-17 | 1989-10-17 | 1990-04-18 | $7700.00 | Window Closed / Lapsed |