Patent US4082840A successfully refreshed from Google Patents.
US4082840A
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US
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Bone seeking technetium 99m complex
Assignee: Bristol Myers Squibb Pharma Co
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Filing: 1976-02-13
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Granted: 1978-04-04
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Expires: 1996-02-13
Abstract
Abstract A technetium-99m-stannous-phosphate complex in which the phosphate moiety includes pyrophosphate and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate, a method of making the same, a method of using the same by in vivo intravenous administration to a mammal of the sterile, nonpyrogenic complex followed by radioassay scanning or imaging the skeletal structure, and a kit made up of a stannous-phosphate complex in which the phosphate moiety is pyrophosphate and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate.
Inventors
- 👤 Norman Adler
- 👤 Leopoldo Lazaro Camin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 12:21
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K2123/00
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
65 words
A composition for forming a complex with technetium-99m for radioactive scanning, comprising a stannous-phosphate complex, the phosphate moiety of which comprises pyrophosphate, said phosphate moiety containing no more than 25% of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a polyphosphate moiety of molecular weight greater than pyrophosphate, the weight ratio of stannous to pyrophosphate moiety ranging from 10 -3 to 0.50.
Claim 2
Dependent Claim
65 words
A composition for forming a complex with technetium-99m for radioactive scanning, comprising a stannous-phosphate complex, the phosphate moiety of which comprises pyrophosphate, said phosphate moiety containing no more than 25% of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a polyphosphate moiety of molecular weight greater than pyrophosphate, the weight ratio of stannous to pyrophosphate moiety ranging from 10 -3 to 0.50.
Claim 3
Dependent Claim
22 words
A composition according to claim 1, in which at least 5% by weight of the phosphate moiety of said complex is pyrophosphate.
Claim 4
Dependent Claim
16 words
A composition according to claim 1, said phosphate moiety being substantially free from said linear polyphosphates.
Claim 5
Dependent Claim
17 words
A composition according to claim 2, substantially 100% by weight of said phosphate moiety being said pyrophosphate.
Claim 6
Dependent Claim
42 words
A composition to claim 1, at least the major portion of any phosphate in said phosphate moiety other than pyrophosphate being selected from the group consisting of a ring phosphate of formula P n O 3n -n , orthophosphate and combinations thereof.
Claim 7
Dependent Claim
12 words
A composition according to claim 5, where n is equal to 3.
Claim 8
Dependent Claim
39 words
A composition according to claim 6, at least 5% by weight of said phosphate moiety being said pyrophosphate and said phosphate moiety containing no more than 10% by weight of said linear polyphosphate of molecular weight greater than pyrophosphate.
Claim 9
Dependent Claim
25 words
A composition according to claim 1, said phosphate moiety consisting of said pyrophosphate, a ring phosphate of formula P n O 3n -n and orthophosphate.
Claim 10
Dependent Claim
10 words
A composition according to claim 8, wherein n is 3.
Claim 11
Dependent Claim
15 words
A composition according to claim 1, at least 90% of said phosphate moiety being pyrophosphate.
Claim 12
Dependent Claim
46 words
A composition according to claim 1, at least 1% of said phosphate moiety being pyrophosphate and any remaining phosphate moiety comprising phosphate of the group consisting of a ring phosphate of formula P n O 3n -n where n is 3 and orthophosphate and combinations thereof.
Claim 13
Dependent Claim
61 words
A composition according to claim 1, any phosphate in said phosphate moiety other than pyrophosphate being selected from the group consisting of ring phosphate of formula P n O 3n -n , one or more phosphates of formula P n O.sub.(3n+1) - (n+2), of which not more than 15% by weight has a n value greater than 2, and combinations thereof.
Claim 14
Dependent Claim
27 words
A sterile non-pyrogenic composition according to claim 1, wherein said stannous-phosphate complex is a freeze dried solid packaged in a sealed sterile, non-pyrogenic container purged or oxygen.
Claim 15
Dependent Claim
39 words
A composition according to claim 13, said complex containing a pH adjusting agent to provide said stannous-phosphate complex with a pH of between 3 and 8 and being packaged in a nitrogen atmosphere in said sealed sterile, non-pyrogenic container.
Claim 16
Dependent Claim
52 words
A sterile, pyrogen free composition for forming a bone seeking complex with technetium-99m according to claim 1, said stannous-phosphate complex being in sterile aqueous solution at a pH of between 3 and 8 for admixture with a sterile pertechnetate solution of technetium-99m to form a technetium-99m labeled stannous-phosphate complex for intravenous administration.
Claim 17
Independent Claim
62 words
A method of preparing a stannous-phosphate complex for use in preparing a complex thereof with technetium-99m comprising admixing a solution of a phosphate with a solid stannous salt, the phosphate moiety of said phosphate comprising pyrophosphate and containing no more than 25% by weight of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a molecular weight greater than pyrophosphate.
Claim 18
Independent Claim
62 words
A method of preparing a stannous-phosphate complex for use in preparing a complex thereof with technetium-99m comprising admixing a solution of a phosphate with a solid stannous salt, the phosphate moiety of said phosphate comprising pyrophosphate and containing no more than 25% by weight of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a molecular weight greater than pyrophosphate.
Claim 19
Dependent Claim
15 words
A method according to claim 16, said solid stannous salt being a lyophilized stannous chloride.
Claim 20
Dependent Claim
17 words
A method according to claim 16 said step of admixing being carried out in a non-oxidizing atmosphere.
Claim 21
Dependent Claim
17 words
A method according to claim 18, said atmosphere being selected from a nitrogen atmosphere and a vacuum.
Claim 22
Dependent Claim
44 words
A method according to claim 19, said phosphate solution being formed by admixing the phosphate with water under a nitrogen atmosphere and in a nitrogen flushed container, said method including the step of reducing the oxygen content of said water before forming said solution.
Claim 23
Dependent Claim
38 words
A method according to claim 16, including the step of adjusting the pH of said stannous-phosphate complex to a pH suitable for intravenous in vivo administration into the body of a mammal and lyophilizing the resulting stannous-phosphate complex.
Claim 24
Dependent Claim
15 words
A composition according to claim 1, wherein said stannous-phosphate complex is a freeze dried solid.
Claim 25
Dependent Claim
18 words
A composition according to claim 22, wherein said freeze dried solid is packaged in a sealed, sterile, container.
Claim 26
Dependent Claim
91 words
A composition for forming a complex with technetium-99m, comprising a stannous-phosphate complex, the phosphate moiety of which comprises a phosphate selected from the group consisting of (1) pyrophosphate and (2) a ring phosphate having the formula P n O 3n -n and a molecular weight of less than 300, said phosphate moiety containing no more than 25% by weight of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a molecular weight greater than pyrophosphate, the weight ratio of stannous to pyrophosphate moiety ranging from 10 -3 to 0.5.
Claim 27
Dependent Claim
91 words
A composition for forming a complex with technetium-99m, comprising a stannous-phosphate complex, the phosphate moiety of which comprises a phosphate selected from the group consisting of (1) pyrophosphate and (2) a ring phosphate having the formula P n O 3n -n and a molecular weight of less than 300, said phosphate moiety containing no more than 25% by weight of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a molecular weight greater than pyrophosphate, the weight ratio of stannous to pyrophosphate moiety ranging from 10 -3 to 0.5.
Claim 28
Independent Claim
85 words
A method of preparing a stannous-phosphate complex for use in preparing a complex thereof with technetium-99m comprising admixing a solution of a phosphate with a solid stannous salt, the phosphate moiety of said phosphate being selected from the group consisting of (1) pyrophosphate and (2) a ring phosphate having the formula P n O 3n -n , said phosphate moiety containing no more than 25% by weight of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a molecular weight greater than pyrophosphate.
Claim 29
Independent Claim
85 words
A method of preparing a stannous-phosphate complex for use in preparing a complex thereof with technetium-99m comprising admixing a solution of a phosphate with a solid stannous salt, the phosphate moiety of said phosphate being selected from the group consisting of (1) pyrophosphate and (2) a ring phosphate having the formula P n O 3n -n , said phosphate moiety containing no more than 25% by weight of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a molecular weight greater than pyrophosphate.
Claim 30
Dependent Claim
21 words
A method according to claim 16 wherein the weight ratio of stannous to phosphate moiety is between 10 -3 and 0.50.
Claim 31
Dependent Claim
61 words
A composition for forming a complex with technetium-99m for radioactive scanning, comprising a stannous-phosphate complex, the phosphate moiety of which comprises pyrophosphate, said phosphate moiety containing no more than 25% of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a polyphosphate moiety of molecular weight greater than pyrophosphate, said stannous-phosphate complex being packaged in a sterile sealed container.
Claim 32
Dependent Claim
61 words
A composition for forming a complex with technetium-99m for radioactive scanning, comprising a stannous-phosphate complex, the phosphate moiety of which comprises pyrophosphate, said phosphate moiety containing no more than 25% of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a polyphosphate moiety of molecular weight greater than pyrophosphate, said stannous-phosphate complex being packaged in a sterile sealed container.
Claim 33
Dependent Claim
64 words
A composition for forming a complex with technetium-99m for radioactive scanning, comprising a stannous-phosphate complex, the phosphate moiety of which comprises pyrophosphate, said phospate moiety containing no more than 25% of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a polyphosphate moiety of molecular weight greater than pyrophosphate, said stannous phosphate complex being in the form of a freeze dried solid.
Claim 34
Dependent Claim
64 words
A composition for forming a complex with technetium-99m for radioactive scanning, comprising a stannous-phosphate complex, the phosphate moiety of which comprises pyrophosphate, said phospate moiety containing no more than 25% of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a polyphosphate moiety of molecular weight greater than pyrophosphate, said stannous phosphate complex being in the form of a freeze dried solid.
Claim 35
Dependent Claim
80 words
A composition for forming a complex with technetium-99m for radioactive scanning, comprising a stannous-phosphate complex, the phosphate moiety of which comprises pyrophosphate, said phospate moiety containing no more than 25% of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a polyphosphate moiety of molecular weight greater than pyrophosphate, said stannous-phosphate complex being in sterile aqueous solution at a pH between 3 and 8 for admixture with a sterile technetium-99m solution to form a technetium-99m labelled stannous-phosphate complex.
Claim 36
Dependent Claim
80 words
A composition for forming a complex with technetium-99m for radioactive scanning, comprising a stannous-phosphate complex, the phosphate moiety of which comprises pyrophosphate, said phospate moiety containing no more than 25% of linear polyphosphates of formulation P n O 3n+1 - (n+2) having a polyphosphate moiety of molecular weight greater than pyrophosphate, said stannous-phosphate complex being in sterile aqueous solution at a pH between 3 and 8 for admixture with a sterile technetium-99m solution to form a technetium-99m labelled stannous-phosphate complex.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-03 | 1981-10-03 | 1982-04-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-03 | 1985-10-03 | 1986-04-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-03 | 1989-10-03 | 1990-04-04 | $7700.00 | Window Closed / Lapsed |