Patent US4081334A successfully refreshed from Google Patents.
US4081334A
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US
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Antigen membranes for use in syphilis diagnosis and syphilis diagnosis apparatus using such membranes
Assignee: Nippon Chemiphar Co Ltd
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Filing: 1977-03-18
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Granted: 1978-03-28
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Expires: 1997-03-18
Abstract
Abstract An antigen membrane for syphilis diagnosis comprises cardiolipin immobilized in a polymer maxtrix. The membranes are used in syphilis diagnosis and in an apparatus for syphilis diagnosis.
Inventors
- 👤 Shuichi Suzuki
- 👤 Masuo Aizawa
- 👤 Isao Ishigur
- 👤 Rikio Shinohara
- 👤 Yoichi Nagamura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:12
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/569; G01N33/571; C; C12; C12Q; C12Q1/00; C12Q1/001; C12Q1/002
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
13 words
An antigen membrane for syphilis diagnosis comprising cardiolipin immobilized on a polymer matrix.
Claim 2
Dependent Claim
13 words
An antigen membrane for syphilis diagnosis comprising cardiolipin immobilized on a polymer matrix.
Claim 3
Dependent Claim
17 words
The antigen membrane for syphilis diagnosis of claim 1, in which said polymer is a cellulose derivative.
Claim 4
Dependent Claim
50 words
A method for diagnosing syphilis, comprising bringing one surface of the antigen membrane of claim 1 into contact with a solution to be tested; bringing the other surface of said antigen membrane into contact with a normal serum solution; and measuring electrochemically the membrane potential generated across said antigen membrane.
Claim 5
Dependent Claim
51 words
A method for diagnosing syphilis comprising piling the antigen membrane of claim 1 and an antigen-free membrane to form a piled membrane body; bringing both surfaces of said piled membrane body into contact with a solution to be tested; and measuring electrochemically the membrane potential generated across said piled membrane body.
Claim 6
Dependent Claim
17 words
The method of claim 4, in which said antigen-free membrane is a polymer membrane containing no cardiolipin.
Claim 7
Dependent Claim
13 words
The method of claim 5, in which said polymer is a cellulose derivative.
Claim 8
Dependent Claim
58 words
A method for diagnosing syphilis, comprising bringing one surface of the antigen membrane of claim 1 and one surface of an antigen-free membrane into contact with a solution to be tested; bringing the other surface of said antigen membrane and said antigen-free membrane into contact with an electrolyte; and measuring the membrane potential generated across said antigen membrane.
Claim 9
Dependent Claim
11 words
The method claim 7, in which said electrolyte is physiological saline.
Claim 10
Dependent Claim
17 words
The method of claim 7, in which said antigen-free membrane is a polymer membrane containing no cardiolipin.
Claim 11
Dependent Claim
43 words
An apparatus for use in diagnosing syphilis comprising an electrolytic cell partitioned into two compartments by the antigen membrane of claim 1; electrodes disposed in said compartments; and a detector connected to said electrodes for measuring the membrane potential across said antigen membrane.
Claim 12
Dependent Claim
46 words
An apparatus for use in diagnosing syphilis comprising, an electrolytic cell partitioned into two compartments by the piled membrane body of claim 4; electrodes disposed in said two compartments; and a detector connected to said electrodes for measuring the membrane potential of said piled membrane body.
Claim 13
Dependent Claim
18 words
The apparatus of claim 11 in which said antigen-free membrane is a polymer matrix membrane containing no cardiolipin.
Claim 14
Dependent Claim
14 words
The apparatus of claim 12, in which said polymer matrix is a cellulose derivative.
Claim 15
Dependent Claim
51 words
An apparatus for use in diagnosing syphilis comprising an electrolytic cell partitioned into three compartments by the antigen membrane of claim 1, and by an antigen-free membrane, electrodes disposed in the two outer said compartments; and a detector connected to said electrodes for measuring the membrane potential of said antigen membrane.
Claim 16
Dependent Claim
34 words
The apparatus of claim 14, wherein the central one of said three compartments is adapted to be filled with the solution to be tested and the outer two compartments are filled with an electrolyte.
Claim 17
Dependent Claim
85 words
An apparatus for diagnosing syphilis comprising a first electrolytic cell; a second pair of electrolytic cells disposed inside said first electrolytic cell; the antigen membrane of claim 1 being stretched across the bottom of one of said second pair of electrolytic cells, and an antigen-free membrane being stretched across the bottom of the other of said cells; an electrode disposed in each of said second pair of electrolytic cells; and a detector connected to said electrodes for measuring the membrane potential of said antigen membrane.
Claim 18
Dependent Claim
24 words
The apparatus of claim 16, wherein said inner cells contain electrolyte and said first cell is adapted to contain the solution to be tested.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-27 | 1981-09-26 | 1982-03-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-27 | 1985-09-26 | 1986-03-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-27 | 1989-09-26 | 1990-03-28 | $7700.00 | Window Closed / Lapsed |