Patent US3337352A successfully refreshed from Google Patents.
Patent US4080474A successfully refreshed from Google Patents.
US4080474A
Expired / Lapsed
US
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Hypolipidaemic compositions
Assignee: Beecham Group PLC
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Filing: 1977-02-16
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Granted: 1978-03-21
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Expires: 1997-02-16
Abstract
Abstract Allyloxy benzoic acid derivatives have hypolipidaemic activity, compositions for controlling or reducing serum lipid level in mammals, novel substituted phenoxy and phenylthio allyl compounds and administration of the compositions to mammals in need thereof.
Inventors
- 👤 Richard Mark Hindley
- 👤 Keith Howard Baggaley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 09:01
CPC Classifications
C; C07; C07D; C07D257/00; C07D257/02; C07D257/04; C07C; C07C243/00; C07C243/24; C07C243/26; C07C243/30; C07C243/32; C07C45/00; C07C45/61; C07C45/67; C07C45/68; C07C45/70; C07C45/71; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/40; C07F9/4003; C07F9/4006
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
74 words
A compound of the formula: ##STR12## wherein one of the groups R 2 , R 3 and R 4 is --(CH 2 ) q R 1 in which q is 2 to 12 and R 1 is lower alkanoyl and the remaining groups R 2 , R 3 and R 4 are hydrogen; Z is oxygen or sulphur; and R 5 , r 6 and R 7 are each independently hydrogen or lower alkyl.
Claim 2
Dependent Claim
74 words
A compound of the formula: ##STR12## wherein one of the groups R 2 , R 3 and R 4 is --(CH 2 ) q R 1 in which q is 2 to 12 and R 1 is lower alkanoyl and the remaining groups R 2 , R 3 and R 4 are hydrogen; Z is oxygen or sulphur; and R 5 , r 6 and R 7 are each independently hydrogen or lower alkyl.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 wherein Z is oxygen.
Claim 4
Dependent Claim
11 words
A compound according to claim 1 wherein R 5 is hydrogen.
Claim 5
Dependent Claim
15 words
A compound according to claim 1 wherein Z is oxygen and R 5 is hydrogen.
Claim 6
Dependent Claim
33 words
A compound according to claim 1 of the formula: ##STR13## wherein R is lower alkanoyl; s is is an integer from 2-6; and R 6 and R 7 are hydrogen or lower alkyl.
Claim 7
Dependent Claim
10 words
A compound according to claim 5 wherein R is acetyl.
Claim 8
Dependent Claim
106 words
A pharmaceutical composition for controlling or reducing serum lipid level comprising at least one pharmaceutically acceptable carrier, together with as active hypolipidaemic ingredient an effective amount of a compound of the formula: ##STR14## wherein one of the groups R 2 , R 3 and R 4 is --(CH 2 ) q R 1 in which q is 0 or an integer from 1 to 12 and R 1 is lower alkanoyl, and the remaining groups R 2 , R 3 and R 4 are hydrogen; Z is oxygen or sulphur; and R 5 , r 6 and R 7 are each independently hydrogen or lower alkyl.
Claim 9
Dependent Claim
106 words
A pharmaceutical composition for controlling or reducing serum lipid level comprising at least one pharmaceutically acceptable carrier, together with as active hypolipidaemic ingredient an effective amount of a compound of the formula: ##STR14## wherein one of the groups R 2 , R 3 and R 4 is --(CH 2 ) q R 1 in which q is 0 or an integer from 1 to 12 and R 1 is lower alkanoyl, and the remaining groups R 2 , R 3 and R 4 are hydrogen; Z is oxygen or sulphur; and R 5 , r 6 and R 7 are each independently hydrogen or lower alkyl.
Claim 10
Dependent Claim
13 words
A composition according to claim 7 wherein Z in the compound is oxygen.
Claim 11
Dependent Claim
14 words
A composition according to claim 7 wherein R 5 in the compound is hydrogen.
Claim 12
Dependent Claim
21 words
A composition according to claim 7 wherein Z in the compound is oxygen and R 5 in the compound is hydrogen.
Claim 13
Dependent Claim
35 words
A composition according to claim 7 wherein the active hypolipidaemic ingredient is a compound of the formula: ##STR15## and R 1 , R 6 , R 7 and q are as defined in claim 7.
Claim 14
Dependent Claim
11 words
A composition according to claim 11 wherein R 1 is acetyl.
Claim 15
Dependent Claim
20 words
A composition according to claim 7 wherein R 1 is acetyl and q is an integer from 1 to 12.
Claim 16
Dependent Claim
35 words
A composition according to claim 7 wherein the active hypolipidaemic ingredient is a compound of the formula: ##STR16## and R 1 , R 6 , R 7 and q are as defined in claim 7.
Claim 17
Dependent Claim
46 words
A composition according to claim 7 wherein the active hypolipidaemic ingredient is a compound of the formula: ##STR17## and R 1 , Z and R 6 are as defined in claim 34, r is an integer from 1 to 12 and R 8 is lower alkyl.
Claim 18
Dependent Claim
15 words
A composition according to claim 15 wherein r is an integer from 2 to 6.
Claim 19
Dependent Claim
11 words
A composition according to claim 15 wherein R 1 is acetyl.
Claim 20
Dependent Claim
32 words
A method for controlling or reducing serum lipid level in a mammal in need thereof which comprises administering to the mammal an effective hypolipidaemic amount of a composition according to claim 7.
Claim 21
Dependent Claim
11 words
A method according to claim 18 wherein the administration is oral.
Claim 22
Dependent Claim
32 words
A method for controlling or reducing serum lipid level in a mammal in need thereof which comprises administering to the mammal an effective hypolipidaemic amount of a composition according to claim 8.
Claim 23
Dependent Claim
32 words
A method for controlling or reducing serum lipid level in a mammal in need thereof which comprises administering to the mammal an effective hypolipidaemic amount of a composition according to claim 9.
Claim 24
Dependent Claim
32 words
A method for controlling or reducing serum lipid level in a mammal in need thereof which comprises administering to the mammal an effective hypolipidaemic amount of a composition according to claim 10.
Claim 25
Dependent Claim
32 words
A method for controlling or reducing serum lipid level in a mammal in need thereof which comprises administering to the mammal an effective hypolipidaemic amount of a composition according to claim 11.
Claim 26
Dependent Claim
32 words
A method for controlling or reducing serum lipid level in a mammal in need thereof which comprises administering to the mammal an effective hypolipidaemic amount of a composition according to claim 12.
Claim 27
Dependent Claim
32 words
A method for controlling or reducing serum lipid level in a mammal in need thereof which comprises administering to the mammal an effective hypolipidaemic amount of a composition according to claim 13.
Claim 28
Dependent Claim
32 words
A method for controlling or reducing serum lipid level in a mammal in need thereof which comprises administering to the mammal an effective hypolipidaemic amount of a composition according to claim 14.
Claim 29
Dependent Claim
32 words
A method for controlling or reducing serum lipid level in a mammal in need thereof which comprises administering to the mammal an effective hypolipidaemic amount of a composition according to claim 15.
Claim 30
Dependent Claim
32 words
A method for controlling or reducing serum lipid level in a mammal in need thereof which comprises administering to the mammal an effective hypolipidaemic amount of a composition according to claim 16.
Claim 31
Dependent Claim
32 words
A method for controlling or reducing serum lipid level in a mammal in need thereof which comprises administering to the mammal an effective hypolipidaemic amount of a composition according to claim 17.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-20 | 1981-09-19 | 1982-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-20 | 1985-09-19 | 1986-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-20 | 1989-09-19 | 1990-03-21 | $7700.00 | Window Closed / Lapsed |