Patent US4080441A successfully refreshed from Google Patents.
US4080441A
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Antibacterial oral composition
Assignee: Colgate Palmolive Co
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Filing: 1976-12-27
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Granted: 1978-03-21
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Expires: 1996-12-27
Abstract
Abstract An antibacterial oral composition effective to promote oral hygiene containing an antibacterial antiplaque agent and an additive which reduces staining of dental surfaces without substantially diminishing the antibacterial and antiplaque activity of the agent. Bis-biguanido hexanes, such as chlorhexidine and alexidine, and quaternary ammonium salts, such as benzethonium chloride and cetyl pyridinium chloride, are typical examples of antibacterial agents. The antistain additive is a bis(o-carboxyphenyl)ester of a C2-8 aliphatic dicarboxylic acid such as bis(o-carboxyphenyl)succinate.
Inventors
- 👤 Abdul Gaffar
- 👤 Marijke S. de Vries
- 👤 David L. Carroll
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 15:40
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/37; A61K8/40; A61K8/41; A61K8/416; A61K8/43; A61K2800/00; A61K2800/40; A61K2800/52
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
79 words
An oral composition comprising an oral vehicle, an effective amount of at least one nitrogen-containing antibacterial antiplaque agent which tends to stain or discolor dental enamel surfaces selected from the group consisting of cationic antibacterial antiplaque agent and long chain amine antibacterial antiplaque agent containing a fatty alkyl group of 12 to 18 carbon atoms and at least one bis(o-carboxyphenyl) ester of a C 2-8 aliphatic dicarboxylic acid in an effective amount to prevent said staining of dental enamel.
Claim 2
Dependent Claim
79 words
An oral composition comprising an oral vehicle, an effective amount of at least one nitrogen-containing antibacterial antiplaque agent which tends to stain or discolor dental enamel surfaces selected from the group consisting of cationic antibacterial antiplaque agent and long chain amine antibacterial antiplaque agent containing a fatty alkyl group of 12 to 18 carbon atoms and at least one bis(o-carboxyphenyl) ester of a C 2-8 aliphatic dicarboxylic acid in an effective amount to prevent said staining of dental enamel.
Claim 3
Dependent Claim
50 words
The oral composition of claim 1 wherein said antibacterial antiplaque agent is present in an amount to provide about 0.001% to about 15% by weight based on the free base form of said agent and said bis ester is present in amount of about 0.005% to about 5% by weight.
Claim 4
Dependent Claim
50 words
The oral composition of claim 2 wherein said antibacterial antiplaque agent is present in an amount of about 0.01% to about 5% by weight, based on its free base form, and said bis ester is present in a molar ratio relative to said agent of about 0.2:1 to about 6:1.
Claim 5
Dependent Claim
15 words
The oral composition of claim 2 wherein said antibacterial antiplaque agent is a substituted guanidine.
Claim 6
Dependent Claim
30 words
The oral composition of claim 4 wherein said antibacterial antiplaque agent is a pharmaceutically acceptable water soluble salt of an agent selected from the group consisting of chlorhexidine and alexidine.
Claim 7
Dependent Claim
20 words
The oral composition of claim 5 wherein said antibacterial antiplaque agent is a pharmaceutically acceptable water soluble salt of chlorhexidine.
Claim 8
Dependent Claim
14 words
The oral composition of claim 2 wherein said antibacterial antiplaque agent is benzethonium chloride.
Claim 9
Dependent Claim
28 words
The oral composition of claim 2 wherein said antibacterial antiplaque agent is a quaternary ammonium compound containing 1 to 2 alkyl groups of 8 to 20 carbon atoms.
Claim 10
Dependent Claim
15 words
The oral composition of claim 8 wherein said antibacterial antiplaque agent is cetyl pyridinium chloride.
Claim 11
Dependent Claim
13 words
The oral composition of claim 1 wherein said bis ester is bis(o-carboxyphenyl) succinate.
Claim 12
Dependent Claim
26 words
The oral composition of claim 1 wherein said vehicle is an aqueous-alcohol and said composition is a mouthwash of pH of about 4.5 to about 9.
Claim 13
Dependent Claim
39 words
The oral composition of claim 1 wherein said vehicle comprises a liquid vehicle and a gelling agent and a dentally acceptable polishing material is present and said composition is a toothpaste of pH of about 4.5 to about 9.
Claim 14
Dependent Claim
44 words
The mouthwash composition of claim 11 containing about 0.01% to about 5.0% by weight, based on its free base form, of benzethonium chloride and said bis ester is present in a molar ratio relative to said benzethonium chloride of about 0.2:1 to about 6:1.
Claim 15
Dependent Claim
49 words
The mouthwash composition of claim 11 containing about 0.01% to about 5% by weight, based on its free base form, of a water-soluble pharmaceutically acceptable salt of chlorhexidine and said bis ester is present in a molar ratio relative to said chlorhexidine salt of about 0.2:1 to about 6:1.
Claim 16
Dependent Claim
34 words
A method of preparing an oral composition as defined in claim 1 wherein said bis ester is added to the remaining components of said composition after said components have been contacted with each other.
Claim 17
Dependent Claim
24 words
A method of improving oral hygiene comprising applying to the oral cavity an effective amount of an oral composition as defined in claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-20 | 1981-09-19 | 1982-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-20 | 1985-09-19 | 1986-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-20 | 1989-09-19 | 1990-03-21 | $7700.00 | Window Closed / Lapsed |