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US4078084A
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Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
Assignee: Dow Chemical Co
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Filing: 1977-03-04
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Granted: 1978-03-07
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Expires: 1997-03-04
Abstract
Abstract Novel 2-((3,5-di-tert-butyl-4-hydroxyphenyl)thio)carboxamides and compositions containing the compounds are disclosed. A method for reducing blood serum lipids using the compounds and compositions of the invention is also disclosed.
Inventors
- 👤 Eugene R. Wagner
- 👤 Larry G. Mueller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 12:41
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/60; C07D211/62
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
22 words
A compound of the formula: ##STR3## wherein R 1 represents hydroxy and R 2 represents hydrogen, lower alkyl, hydroxy, or lower hydroxyalkyl.
Claim 2
Dependent Claim
22 words
A compound of the formula: ##STR3## wherein R 1 represents hydroxy and R 2 represents hydrogen, lower alkyl, hydroxy, or lower hydroxyalkyl.
Claim 3
Dependent Claim
8 words
The compound of claim 1 which is 2-((3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)thio)-N-hydroxyhexamide.
Claim 4
Independent Claim
44 words
A method for lowering elevated serum lipids in a mammal which comprises administering internally to the mammal a hypolipidemically effective amount of a compound of the formula: ##STR4## wherein R 1 represents hydroxy and R 2 represents hydrogen, lower alkyl, hydroxy, or lower hydroxyalkyl.
Claim 5
Independent Claim
44 words
A method for lowering elevated serum lipids in a mammal which comprises administering internally to the mammal a hypolipidemically effective amount of a compound of the formula: ##STR4## wherein R 1 represents hydroxy and R 2 represents hydrogen, lower alkyl, hydroxy, or lower hydroxyalkyl.
Claim 6
Dependent Claim
10 words
The method of claim 3 wherein the compound is 2-((3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)thio)-N-hydroxyhexamide.
Claim 7
Dependent Claim
20 words
The method of claim 3 wherein the mammal is administered 5 mg/kg to 30 mg/kg body weight of the compound.
Claim 8
Dependent Claim
36 words
A hypolipidemic composition comprising a suitable pharmaceutical carrier and a hypolipidemically effective amount of a compound having the formula ##STR5## wherein R 1 represents hydroxy and R 2 represents hydrogen, lower alkyl, hydroxy, or lower hydroxyalkyl.
Claim 9
Dependent Claim
36 words
A hypolipidemic composition comprising a suitable pharmaceutical carrier and a hypolipidemically effective amount of a compound having the formula ##STR5## wherein R 1 represents hydroxy and R 2 represents hydrogen, lower alkyl, hydroxy, or lower hydroxyalkyl.
Claim 10
Dependent Claim
10 words
The composition of claim 6 wherein the compound is 2-((3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)thio)-N-hydroxyhexamide.
References Cited (Backward Citations)
US3927092A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-06 | 1981-09-05 | 1982-03-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-06 | 1985-09-05 | 1986-03-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-06 | 1989-09-05 | 1990-03-07 | $7700.00 | Window Closed / Lapsed |