Patent US4077957A successfully refreshed from Google Patents.
US4077957A
Expired / Lapsed
US
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6-(Bromomethyl)-2,4-diaminopteridine hydrobromide
Assignee: United States Department of Health and Human Services
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Filing: 1977-04-11
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Granted: 1978-03-07
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Expires: 1997-04-11
Abstract
Abstract A pteridine compound having the formula of 6-(bromomethyl)-2,4-diaminopteridine hydrobromide. 2,4-diamino-6-pteridine-methanol.HBr is reacted with triphenylphosphine dibromide or phosphorus tribromide to form 6-(bromomethyl)-2,4-diaminopteridine hydrobromide. The bromine atom in the molecule can then be replaced with the functional group, N-[4-(methylamino)-benzoyl]-L-glutamic acid in the case of methotrexate and N-(4-aminobenzoyl)-L-glutamic acid in the case of aminopterin.
Inventors
- 👤 James R. Piper
- 👤 John A. Montgomery
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 21:49
CPC Classifications
C; C07; C07D; C07D475/00; C07D475/06; C07D475/08
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
8 words
A compound having the formula of 6-(bromomethyl)-2,4-diaminopteridine hydrobromide.
Claim 2
Dependent Claim
8 words
A compound having the formula of 6-(bromomethyl)-2,4-diaminopteridine hydrobromide.
References Cited (Backward Citations)
US2710866A
Cited
US3242178A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-06 | 1981-09-05 | 1982-03-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-06 | 1985-09-05 | 1986-03-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-06 | 1989-09-05 | 1990-03-07 | $7700.00 | Window Closed / Lapsed |