7 2-(Aminocarbonylalkoxyimino)acetamido! derivatives of cephalosporin

Abstract

Abstract Cephalosporin antibiotics in which the 7β-acylamido group has the structure ##STR1## (WHERE R is phenyl, thienyl or furyl; R a and R b are each selected from hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 3-7 cycloalkyl, phenyl, naphthyl, thienyl, furyl, carboxy, C 2-5 alkoxycarbonyl, aminocarbonyl, N-substituted aminocarbonyl and cyano, or R a and R b together with the carbon atom to which they are attached form a C 3-7 cycloalkylidene or cycloalkenylidene group; R c is hydrogen or C 1-4 alkyl; and m and n are each 0 or 1 such that the sum of m and n is 0 or 1) exhibit broad spectrum antibiotic activity characterized by particularly high activity against gram negative microorganisms, including those which produce β-lactamases. The compounds, which are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer, have particularly good activity against Proteus organisms including indole positive strains and, especially when both R a and R b are other than hydrogen, against Pseudomonas organisms.

Inventors

• 👤 Michael W. Foxton
• 👤 Gordon I. Gregory
• 👤 David M. Rogers

Bibliographic Details