US4073931A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nitroglycerine inclusion compounds with cyclodextrin and composition containing same
Assignee: Nippon Kayaku Co Ltd
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Filing: 1975-03-25
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Granted: 1978-02-14
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Expires: 1995-03-25
Abstract
Abstract Nitroglycerine inclusion compound in cyclodextrin is obtained by contacting cyclodextrin with nitroglycerine in the presence of water. The inclusion compound is very stable as a quick effective drug for treating angina pectoris and easy in handling.
Inventors
- 👤 Eiichiro Akito
- 👤 Yoshiyuki Nakajima
- 👤 Masayoshi Horioka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:29
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; A61K31/00; A61K31/21; A61K9/00; A61K9/0012; A61K9/0053; A61K9/006; B; B82; B82Y; B82Y5/00; C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0012; C08B37/0015
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
7 words
An inclusion compound of nitroglycerine in cyclodextrin.
Claim 2
Dependent Claim
7 words
An inclusion compound of nitroglycerine in cyclodextrin.
Claim 3
Dependent Claim
39 words
A process for producing an inclusion compound of nitroglycerine in cyclodextrin which comprises contacting 0.2 to 0.001 part by weight of nitroglycerine with 1 part by weight of cyclodextrin in the presence of 5-70 parts by weight of water.
Claim 4
Dependent Claim
39 words
A process for producing an inclusion compound of nitroglycerine in cyclodextrin which comprises contacting 0.2 to 0.001 part by weight of nitroglycerine with 1 part by weight of cyclodextrin in the presence of 5-70 parts by weight of water.
Claim 5
Dependent Claim
28 words
A process according to claim 2, wherein said nitroglycerine is dissolved in a hydrophilic organic solvent and then brought into contact with a mixture of cyclodextrin and water.
Claim 6
Dependent Claim
26 words
A process according to claim 3, wherein the hydrophilic organic solvent is at least one member selected from the group consisting of methanol, ethanol and acetone.
Claim 7
Dependent Claim
59 words
A pharmaceutical tablet comprising a blend of (1) an inclusion compound of nitroglycerine in cyclodextrin, and (2) tablet-forming fine particles comprising at least one excipient selected from the group consisting of lactose, corn starch, mannitol and fine crystalline cellulose; said particles further comprising at least one binder selected from the group consisting of polyvinylpyrrolidone, gum arabic and methyl cellulose.
Claim 8
Dependent Claim
59 words
A pharmaceutical tablet comprising a blend of (1) an inclusion compound of nitroglycerine in cyclodextrin, and (2) tablet-forming fine particles comprising at least one excipient selected from the group consisting of lactose, corn starch, mannitol and fine crystalline cellulose; said particles further comprising at least one binder selected from the group consisting of polyvinylpyrrolidone, gum arabic and methyl cellulose.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-02-13 | 1981-08-15 | 1982-02-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-02-13 | 1985-08-15 | 1986-02-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-02-13 | 1989-08-15 | 1990-02-14 | $7700.00 | Window Closed / Lapsed |