Patent US4073797A successfully refreshed from Google Patents.
US4073797A
Expired / Lapsed
US
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Sulphur containing derivatives
Assignee: Hoffmann La Roche Inc
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Filing: 1976-10-01
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Granted: 1978-02-14
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Expires: 1996-10-01
Abstract
Abstract A novel class of dithiane and disulfone compound is described. These compounds are pharmaceutically active as coronary dilating agents and thus can be used therapeutically in cases of insufficient cardiac blood supply, i.e., in the treatment of angina pectoris. A preferred compound is N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-N-methyl-m-dithiane -2-propylamine-1,1-3,3-tetraoxide.
Inventors
- 👤 Henri Ramuz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 03:08
CPC Classifications
C; C07; C07D; C07D339/00; C07D339/08; C07C; C07C45/00; C07C45/45; C07C45/46; C07D339/02; C07D339/06
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
162 words
A compound of the formula ##STR23## wherein R is a group of the formula ##STR24## in which two adjacent R 1 , R 2 and R 3 symbols together are methylenedioxy, ethylenedioxy or butadien-1,3-ylene-1,4; R 4 is hydrogen or lower alkyl; R 5 , R 6 and R 7 each independently is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy or benzyloxy or two adjacent R 5 , R 6 and R 7 symbols together are methylenedioxy or ethylenedioxy; X is a sulphur atom, SO or SO 2 ; Y is a straight-chain or branched-chain, aliphatic group which may be substituted with hydroxy and containing 2-8 carbon atoms, of which 2-4 carbon atoms are present in the chain; and Z is a straight-chain or branched-chain aliphatic group which may be substituted with hydroxy and containing 1-8 carbon atoms, of which 1-4 carbon atoms are present in the chain; m is zero or 1 and n is 2 or 3, and acid salts thereof.
Claim 2
Dependent Claim
162 words
A compound of the formula ##STR23## wherein R is a group of the formula ##STR24## in which two adjacent R 1 , R 2 and R 3 symbols together are methylenedioxy, ethylenedioxy or butadien-1,3-ylene-1,4; R 4 is hydrogen or lower alkyl; R 5 , R 6 and R 7 each independently is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy or benzyloxy or two adjacent R 5 , R 6 and R 7 symbols together are methylenedioxy or ethylenedioxy; X is a sulphur atom, SO or SO 2 ; Y is a straight-chain or branched-chain, aliphatic group which may be substituted with hydroxy and containing 2-8 carbon atoms, of which 2-4 carbon atoms are present in the chain; and Z is a straight-chain or branched-chain aliphatic group which may be substituted with hydroxy and containing 1-8 carbon atoms, of which 1-4 carbon atoms are present in the chain; m is zero or 1 and n is 2 or 3, and acid salts thereof.
Claim 3
Dependent Claim
8 words
The compound of claim 1 which is N-(3,4-dimethoxyphenethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)-m-dithiane-2-propylamine.
Claim 4
Dependent Claim
9 words
The compound of claim 1 which is N-(3,4-dimethoxyphenethyl)-N-methyl-2-(3,4-methylene-dioxphenyl)-m-dithiane-2-propylamine-1,1,3,3-tetraoxide hydrochloride.
Claim 5
Dependent Claim
138 words
A compound of the formula ##STR25## wherein R is a group of the formula ##STR26## in which two adajcent R 1 , R 2 and R 3 symbols together are methylenedioxy, ethylenedioxy or butadien-1,3-xylene-1,4; R 4 is hydrogen or lower alkyl; R 5 , R 6 and R 7 each independently is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy or benzyloxy or two adjacent R 5 , R 6 and R 7 symbols together are methylenedioxy or ethylenedioxy; y is a straight-chain or branched-chain, optionally hydroxy-substituted, aliphatic group containing 2-8 carbon atoms, of which 2-4 atoms are present in the chain, and Z repesents a straight-chain or branched-chain, optionally hydroxy-substituted aliphatic group containing 1-8 carbon atoms, of which 1-4 carbon atoms are present in the chain, and m stands for zero or 1, and acid addition salts thereof.
Claim 6
Dependent Claim
138 words
A compound of the formula ##STR25## wherein R is a group of the formula ##STR26## in which two adajcent R 1 , R 2 and R 3 symbols together are methylenedioxy, ethylenedioxy or butadien-1,3-xylene-1,4; R 4 is hydrogen or lower alkyl; R 5 , R 6 and R 7 each independently is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy or benzyloxy or two adjacent R 5 , R 6 and R 7 symbols together are methylenedioxy or ethylenedioxy; y is a straight-chain or branched-chain, optionally hydroxy-substituted, aliphatic group containing 2-8 carbon atoms, of which 2-4 atoms are present in the chain, and Z repesents a straight-chain or branched-chain, optionally hydroxy-substituted aliphatic group containing 1-8 carbon atoms, of which 1-4 carbon atoms are present in the chain, and m stands for zero or 1, and acid addition salts thereof.
Claim 7
Dependent Claim
165 words
A compound of the formula ##STR27## , wherein R is a group of the formula ##STR28## in which two adjacent R 1 , R 2 and R 3 symbols together are methylenedioxy, ethylenedioxy or butadien-1,3-ylene1,4; R 4 is hydrogen or lower alkyl; R 5 , R 6 and R 7 each independently is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, or benzyloxy or two adjacent R 5 , R 6 and R 7 symbols together are methylenedioxy or ethylenedioxy; X is a sulphur atom, SO or SO 2 ; Y 1 is a straight-chain or branched-chain aliphatic group which may be substituted with hydroxy and containing 2-8 carbon atoms, of which 2-4 carbon atoms are present in the chain; Z 1 is a straight-chain or branched-chain, aliphatic group which may be substituted with carbonyl and containing 1-8 carbon atoms, of which 1-4 carbon atoms are present in the chain; m is zero or 1 and n is 2 or 3, and acid addition salts thereof.
Claim 8
Dependent Claim
165 words
A compound of the formula ##STR27## , wherein R is a group of the formula ##STR28## in which two adjacent R 1 , R 2 and R 3 symbols together are methylenedioxy, ethylenedioxy or butadien-1,3-ylene1,4; R 4 is hydrogen or lower alkyl; R 5 , R 6 and R 7 each independently is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, or benzyloxy or two adjacent R 5 , R 6 and R 7 symbols together are methylenedioxy or ethylenedioxy; X is a sulphur atom, SO or SO 2 ; Y 1 is a straight-chain or branched-chain aliphatic group which may be substituted with hydroxy and containing 2-8 carbon atoms, of which 2-4 carbon atoms are present in the chain; Z 1 is a straight-chain or branched-chain, aliphatic group which may be substituted with carbonyl and containing 1-8 carbon atoms, of which 1-4 carbon atoms are present in the chain; m is zero or 1 and n is 2 or 3, and acid addition salts thereof.
Claim 9
Dependent Claim
165 words
A compound of the formula ##STR29## ##STR30## , wherein R is a group of the formula in which two adjacent R 1 , R 2 , and R 3 symbols together are methylenedioxy, ethylenedioxy or butadien-1,3-ylene-1,4; R 5 , R 6 and R 7 each independently is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy or benzyloxy ot two adjacent R 5 , R 6 and R 7 symbols together are methylenedioxy or ethylenedioxy; X is a sulphur atom, SO or SO 2 ; Y is a straight-chain or branched-chain aliphatic group which may be substituted with hydroxy and containing 2-8 carbon atoms, of which 2-4 carbon atoms are present in the chain; Z is a straight-chain or branched-chain aliphatic group which may be substituted with hydroxy and containing 1-8 carbon atoms, of which 1-4 carbon atoms are present in the chain; m is zero of 1; n is 2 or 3 and A is the group ##STR31## wherein R 4 is hydrogen or lower alkyl.
Claim 10
Dependent Claim
165 words
A compound of the formula ##STR29## ##STR30## , wherein R is a group of the formula in which two adjacent R 1 , R 2 , and R 3 symbols together are methylenedioxy, ethylenedioxy or butadien-1,3-ylene-1,4; R 5 , R 6 and R 7 each independently is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy or benzyloxy ot two adjacent R 5 , R 6 and R 7 symbols together are methylenedioxy or ethylenedioxy; X is a sulphur atom, SO or SO 2 ; Y is a straight-chain or branched-chain aliphatic group which may be substituted with hydroxy and containing 2-8 carbon atoms, of which 2-4 carbon atoms are present in the chain; Z is a straight-chain or branched-chain aliphatic group which may be substituted with hydroxy and containing 1-8 carbon atoms, of which 1-4 carbon atoms are present in the chain; m is zero of 1; n is 2 or 3 and A is the group ##STR31## wherein R 4 is hydrogen or lower alkyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-02-13 | 1981-08-15 | 1982-02-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-02-13 | 1985-08-15 | 1986-02-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-02-13 | 1989-08-15 | 1990-02-14 | $7700.00 | Window Closed / Lapsed |