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US4071618A
Expired / Lapsed
US
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Process for preparing virus disease live vaccines
Assignee: Research Foundation for Microbial Diseases of Osaka University
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Filing: 1976-07-06
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Granted: 1978-01-31
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Expires: 1996-07-06
Abstract
Abstract Process for preparing a virus disease live vaccine by employing culture of a quail embryonated egg or tissue culture of a quail embryo fibroblast for cultivation of the virus. The vaccine obtained according to the present invention is effective for immunization of animals and humans against the virus disease. The vaccine is avirulent, scarcely subject to induction of unfavorable factors accompanying the present tissue used for isolation of the virus therefrom, and economically productible.
Inventors
- 👤 Takeo Konobe
- 👤 Tetsuo Onoda
- 👤 Koichi Ono
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 04:16
CPC Classifications
C; C12; C12N; C12N7/00; C12N2740/00; C12N2740/00011; C12N2740/10011; C12N2740/11011; C12N2740/11051; C12N2740/14011; C12N2740/14051
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
118 words
In a process for the production of a live virus vaccine by the tissue culture method comprising the adaptation, attenuation and propagation of a virus selected from the group consisting of rubella, mumps, influenza A, influenza B, distemper, Newcastle disease, Japanese encephalitis, dengue fever, rabies, and turkey Herpes viruses, the improvement comprising a. incubating the virus in a culture of a quail embryonated egg or tissue culture of a quail embryo fibroblast, and b. subjecting the virus to successive cultivation in a culture medium for a sufficient number of passages to propagate the virus, at least one passage in the successive cultivation being effected in a culture medium containing a quail embryonated egg or a quail embryo fibroblast.
Claim 2
Dependent Claim
118 words
In a process for the production of a live virus vaccine by the tissue culture method comprising the adaptation, attenuation and propagation of a virus selected from the group consisting of rubella, mumps, influenza A, influenza B, distemper, Newcastle disease, Japanese encephalitis, dengue fever, rabies, and turkey Herpes viruses, the improvement comprising a. incubating the virus in a culture of a quail embryonated egg or tissue culture of a quail embryo fibroblast, and b. subjecting the virus to successive cultivation in a culture medium for a sufficient number of passages to propagate the virus, at least one passage in the successive cultivation being effected in a culture medium containing a quail embryonated egg or a quail embryo fibroblast.
Claim 3
Dependent Claim
13 words
A process according to claim 1, wherein said virus is a rubella virus.
Claim 4
Dependent Claim
13 words
A process according to claim 1, wherein said virus is a mumps virus.
Claim 5
Dependent Claim
14 words
A process according to claim 1, wherein said virus is an influenza A virus.
Claim 6
Dependent Claim
14 words
A process according to claim 1, wherein said virus is an influenza B virus.
Claim 7
Dependent Claim
13 words
A process according to claim 1, wherein said virus is a distemper virus.
Claim 8
Dependent Claim
14 words
A process according to claim 1, wherein said virus is a Newcastle disease virus.
Claim 9
Dependent Claim
14 words
A process according to claim 1, wherein said virus is a Japanese encephalitis virus.
Claim 10
Dependent Claim
14 words
A process according to claim 1, wherein said virus is a dengue fever virus.
Claim 11
Dependent Claim
13 words
A process according to claim 1, wherein said virus is a rabies virus.
References Cited (Backward Citations)
US3674861A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-30 | 1981-08-01 | 1982-01-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-30 | 1985-08-01 | 1986-01-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-30 | 1989-08-01 | 1990-01-31 | $7700.00 | Window Closed / Lapsed |