US4071318A
Expired / Lapsed
US
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Test composition and device for determining peroxidatively active substances
Assignee: Bayer Corp
•
Filing: 1977-03-14
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Granted: 1978-01-31
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Expires: 1997-03-14
Abstract
Abstract A test composition and device are disclosed for determining the presence of peroxidatively active substances, such as hemoglobin, in a test sample. Also disclosed is a one-dip method for preparing the device.
Inventors
- 👤 Charles Tak Wai Lam
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:40
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/72; G01N33/721; G01N33/725; C; C12; C12Q; C12Q1/00; C12Q1/26; C12Q1/28; C12Q2326/00; C12Q2326/10; C12Q2326/14
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
62 words
A test composition for detecting the presence of a peroxidatively active substance in a sample comprising an organic hydroperoxide, an indicator capable of producing a detectable response in the presence of a hydroperoxide and a peroxidatively active substance, and a borate ester having the structure ##STR3## in which m, n and p, same or different, are integers of 1 to about 4.
Claim 2
Dependent Claim
62 words
A test composition for detecting the presence of a peroxidatively active substance in a sample comprising an organic hydroperoxide, an indicator capable of producing a detectable response in the presence of a hydroperoxide and a peroxidatively active substance, and a borate ester having the structure ##STR3## in which m, n and p, same or different, are integers of 1 to about 4.
Claim 3
Dependent Claim
22 words
The composition of claim 1 in which the borate ester is trimethanolamine borate, triethanolamine borate, tri (n-propanol) amine borate, or mixtures thereof.
Claim 4
Dependent Claim
13 words
The composition of claim 1 in which the borate ester is triethanolamine borate.
Claim 5
Dependent Claim
17 words
The composition of claim 1 in which the indicator is benzidine, o-tolidine, 3,3',5,5'-tetramethylbenzidine, 2,7-diaminofluorene or mixtures thereof.
Claim 6
Dependent Claim
23 words
The composition of claim 1 in which the organic hydroperoxide is t-butyl hydroperoxide, cumene hydroperoxide, diisopropylbenzene hydroperoxide, 2,5-dimethylhexane-2,5-dihydroperoxide, paramenthane hydroperoxide or mixtures thereof.
Claim 7
Dependent Claim
13 words
The composition of claim 1 in which the organic hydroperoxide in cumene hydroperoxide.
Claim 8
Dependent Claim
13 words
The composition of claim 6 in which the borate ester is triethanolamine borate.
Claim 9
Dependent Claim
21 words
The composition of claim 6 in which the borate ester is trimethanolamine borate, triethanolamine borate, tri-(n-propanol) amine borate or mixtures thereof.
Claim 10
Dependent Claim
17 words
The composition of claim 8 in which the indicator is benzidine, o-tolidine, 3,3',5,5'-tetramethylbenzidine, 2,7-diaminofluorene or mixtures thereof.
Claim 11
Dependent Claim
24 words
A test composition for determining the presence of a peroxidatively active constituent in a sample, the composition comprising cumene hydroperoxide, o-tolidine, and triethanolamine borate.
Claim 12
Dependent Claim
24 words
A test composition for determining the presence of a peroxidatively active constituent in a sample, the composition comprising cumene hydroperoxide, o-tolidine, and triethanolamine borate.
Claim 13
Dependent Claim
70 words
A test device for determining the presence of a constituent in a sample wherein a carrier matrix is incorporated with a test composition comprising an organic hydroperoxide, an indicator capable of forming a detectable response in the presence of a hydroperoxide and a peroxidatively active substance, and a borate ester having the structure ##STR4## in which m, n and p, same or different, are integers of 1 to about 4.
Claim 14
Dependent Claim
70 words
A test device for determining the presence of a constituent in a sample wherein a carrier matrix is incorporated with a test composition comprising an organic hydroperoxide, an indicator capable of forming a detectable response in the presence of a hydroperoxide and a peroxidatively active substance, and a borate ester having the structure ##STR4## in which m, n and p, same or different, are integers of 1 to about 4.
Claim 15
Dependent Claim
21 words
The device of claim 11 in which the borate ester is trimethanolamine borate, triethanolamine borate, tri(n-propanol) amine borate or mixtures thereof.
Claim 16
Dependent Claim
13 words
The device of claim 11 in which the borate ester is triethanolamine borate.
Claim 17
Dependent Claim
17 words
The device of claim 11 in which the indicator is benzidine, o-tolidine, 3,3',5,5'-tetramethylbenzidine, 2,7-diaminofluorene, or mixtures thereof.
Claim 18
Dependent Claim
23 words
The device of claim 11 in which the organic hydroperoxide is t-butyl hydroperoxide, cumene hydroperoxide, diisopropylbenzene hydroperoxide, 2,5-dimethylhexane-2,5-dihydroperoxide, paramenthane hydroperoxide of mixtures thereof.
Claim 19
Dependent Claim
13 words
The device of claim 11 in which the organic hydroperoxide is cumene hydroperoxide.
Claim 20
Dependent Claim
20 words
The device of claim 16 in which the borate ester is trimethanolamine borate, triethanolamine borate, tri-(n-propanol)amine borate or mixtures thereof.
Claim 21
Dependent Claim
13 words
The device of claim 16 in which the borate ester is triethanolamine borate.
Claim 22
Dependent Claim
17 words
The device of claim 18 in which the indicator is benzidine, o-tolidine, 3,3'5,5'-tetramethylbenzidine, 2,7-diaminofluorene, or mixtures thereof.
Claim 23
Dependent Claim
33 words
A test device for determining the presence of a peroxidatively active constituent in a sample, the device having a carrier matrix incorporated with a test composition comprising cumene hydroperoxide, o-tolidine and triethanolamine borate.
Claim 24
Dependent Claim
33 words
A test device for determining the presence of a peroxidatively active constituent in a sample, the device having a carrier matrix incorporated with a test composition comprising cumene hydroperoxide, o-tolidine and triethanolamine borate.
Claim 25
Dependent Claim
91 words
A one-dip process for preparing a test device for determining the presence of a peroxidatively active constituent in a sample comprising the steps of preparing a mixture of a test composition comprising an organic hydroperoxide, an indicator capable of producing a detectable response in the presence of a hydroperoxide and a peroxidatively active substance, and a borate ester having the structure ##STR5## in which m, n and p, same or different, are integers from 1 to about 4, and a suitable liquid diluent, and incorporating said mixture with a carrier matrix.
Claim 26
Dependent Claim
91 words
A one-dip process for preparing a test device for determining the presence of a peroxidatively active constituent in a sample comprising the steps of preparing a mixture of a test composition comprising an organic hydroperoxide, an indicator capable of producing a detectable response in the presence of a hydroperoxide and a peroxidatively active substance, and a borate ester having the structure ##STR5## in which m, n and p, same or different, are integers from 1 to about 4, and a suitable liquid diluent, and incorporating said mixture with a carrier matrix.
Claim 27
Dependent Claim
21 words
The process of claim 21 in which the borate ester is trimethanolamine borate, triethanolamine borate, tri (n-propyl)amine borate or mixtures thereof.
Claim 28
Dependent Claim
13 words
The process of claim 21 in which the borate ester is triethanolamine borate.
Claim 29
Dependent Claim
17 words
The process of claim 21 in which the indicator is benzidine, o-tolidine, 3,3',5,5'-tetramethylbenzidine, 2,7-diaminofluorene, or mixtures thereof.
Claim 30
Dependent Claim
13 words
The process of claim 21 in which the organic hydroperoxide is cumene hydroperoxide.
Claim 31
Dependent Claim
23 words
The process of claim 21 in which the organic hydroperoxide is t-butyl hydroperoxide, cumene hydroperoxide, diisopropylbenzene hydroperoxide, 2,5-dimethylhexane-2,5-dihydroperoxide, paramenthane hydroperoxide, or mixtures thereof.
Claim 32
Dependent Claim
20 words
The process of claim 26 in which the borate ester is trimethanolamine borate, triethanolamine borate, tri-(n-propanol)amine borate or mixtures thereof.
Claim 33
Dependent Claim
13 words
The process of claim 26 in which the borate ester is triethanolamine borate.
Claim 34
Dependent Claim
17 words
The process of claim 28 in which the indicator is benzidine, o-tolidine, 3,3',5,5'-tetramethylbenzidine, 2,7-diaminofluorene or mixtures thereof.
Claim 35
Dependent Claim
51 words
A one-dip process for preparing a test device for determining the presence of a peroxidatively active constituent in a sample, comprising the steps of preparing a mixture of a test composition comprising cumene hydroperoxide, o-tolidine and triethanolamine borate, and a suitable liquid diluent, and incorporating the test compound with a matrix.
Claim 36
Dependent Claim
51 words
A one-dip process for preparing a test device for determining the presence of a peroxidatively active constituent in a sample, comprising the steps of preparing a mixture of a test composition comprising cumene hydroperoxide, o-tolidine and triethanolamine borate, and a suitable liquid diluent, and incorporating the test compound with a matrix.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-30 | 1981-08-01 | 1982-01-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-30 | 1985-08-01 | 1986-01-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-30 | 1989-08-01 | 1990-01-31 | $7700.00 | Window Closed / Lapsed |