Patent US4070455A successfully refreshed from Google Patents.
US4070455A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing injectable desensitizing compositions and products thereof in microparticle form
Assignee: Beecham Group PLC
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Filing: 1976-10-04
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Granted: 1978-01-24
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Expires: 1996-10-04
Abstract
Abstract Finely divided micro-particles of tyrosine having a glutaraldehyde-treated allergen dispersed therein are prepared by mixing a solution of tyrosine in a strong aqueous acid with a solution of glutaraldehyde-treated ragweed pollen extract as the allergen and then neutralizing the resultant solution.
Inventors
- 👤 Geoffrey Green
- 👤 Brian George Overell
- 👤 Anthony Phillip Hart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:31
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/35; A61K39/36; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
69 words
A process of preparing finely-divided micro-particles of tyrosine having a water-soluble, glutaraldehyde-treated extract of ragweed pollen as allergen dispersed therein, which process comprises: mixing (a) an aqueous solution of a water-soluble glutaraldehyde-modified ragweed pollen extract with (b) a solution of tyrosine in a strong aqueous acid, and neutralising such mixture of solutions, thereby precipitating the required finely-divided micro-particles of tyrosine containing a water-soluble, glutaraldehyde-treated ragweed pollen extract dispersed therein.
Claim 2
Dependent Claim
69 words
A process of preparing finely-divided micro-particles of tyrosine having a water-soluble, glutaraldehyde-treated extract of ragweed pollen as allergen dispersed therein, which process comprises: mixing (a) an aqueous solution of a water-soluble glutaraldehyde-modified ragweed pollen extract with (b) a solution of tyrosine in a strong aqueous acid, and neutralising such mixture of solutions, thereby precipitating the required finely-divided micro-particles of tyrosine containing a water-soluble, glutaraldehyde-treated ragweed pollen extract dispersed therein.
Claim 3
Dependent Claim
32 words
A process according to claim 1 wherein the aqueous solution of modified ragweed pollen is obtained directly by reacting an aqueous solution of whole ragweed pollen with glutaraldehyde under substantially neutral conditions.
Claim 4
Dependent Claim
26 words
A pharmaceutical composition which can be injected, which composition comprises an anti-allergy effective amount of the material of claim 10 together with a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
18 words
A process according to claim 1, wherein the strong aqueous acid employed in stage (b) is hydrochloric acid.
Claim 6
Dependent Claim
15 words
A process according toclaim 1, wherein sodium hydroxide is employed to neutralise the reaction mixture.
Claim 7
Dependent Claim
22 words
A process according to claim 1, wherein a buffer is added to the reaction mixture before the neutralisation procedure is carried out.
Claim 8
Dependent Claim
28 words
A process according to claim 1, wherein the neutralising base and the solution of tyrosine in acid are run into the solution of modified ragweed pollen extract simultaneously.
Claim 9
Dependent Claim
38 words
A process according to claim 7, which is carried out at substantially constant pH by regulation of the rates of simultaneous addition of the solution of tyrosine and neutralising solution to the solution of modified ragweed pollen extract.
Claim 10
Dependent Claim
15 words
A process according to claim 1, wherein the mixture of solutions is neutralised after mixing.
Claim 11
Dependent Claim
14 words
Finely-divided micro-particles of tyrosine having a water soluble glutaraldehyde-treated ragweed pollen extract dispersed therein.
Claim 12
Dependent Claim
14 words
Finely-divided micro-particles of tyrosine having a water soluble glutaraldehyde-treated ragweed pollen extract dispersed therein.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-23 | 1981-07-25 | 1982-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-23 | 1985-07-25 | 1986-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-23 | 1989-07-25 | 1990-01-24 | $7700.00 | Window Closed / Lapsed |