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US4069313A
Expired / Lapsed
US
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Water-in-oil adjuvant composition
Assignee: Merck and Co Inc
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Filing: 1976-04-07
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Granted: 1978-01-17
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Expires: 1996-04-07
Abstract
Abstract Pure isomannide monooleate and pure aluminum monostearate are used singularly or in combination in the preparation of emulsion type adjuvant vaccines to yield an adjuvant superior to prior art adjuvants which employ commercial mannide monooleate and aluminum monostearate. Highly desirable formulations are obtained by the inclusion of pure aluminum monostearate as a stabilizer in combination with the pure isomannide monooleate.
Inventors
- 👤 Allen F. Woodhour
- 👤 Maurice R. Hilleman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 03:03
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K39/00; A61K39/12; A61K39/145; A61K39/39; A61K2039/555; A61K2039/55505; A61K2039/55511; A61K2039/55566; A61K2039/70; C; C12; C12N; C12N2760/00; C12N2760/00011; C12N2760/16011; C12N2760/16111; C12N2760/16134; C12N2760/16211; C12N2760/16234; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
38 words
An adjuvant composition comprising a physiologically acceptable injectable oil and from about 0.5% to about 10% by volume of a stabilizer consisting essentially of aluminum monostearate, the aluminum monostearate being essentially free of any other fatty acid radical.
Claim 2
Dependent Claim
38 words
An adjuvant composition comprising a physiologically acceptable injectable oil and from about 0.5% to about 10% by volume of a stabilizer consisting essentially of aluminum monostearate, the aluminum monostearate being essentially free of any other fatty acid radical.
Claim 3
Dependent Claim
13 words
The adjuvant composition of claim 1 wherein the oil is a vegetable oil.
Claim 4
Dependent Claim
13 words
The adjuvant composition of claim 1 wherein the oil is a mineral oil.
Claim 5
Dependent Claim
13 words
The adjuvant composition of claim 2 wherein the vegetable oil is peanut oil.
Claim 6
Dependent Claim
39 words
An adjuvant vaccine composition comprising a physiologically acceptable injectable oil, an antigen and from about 0.5 to 10% by volume of stabilizer consisting essentially of aluminum monostearate, the aluminum monostearate being essentially free of any other fatty acid radical.
Claim 7
Dependent Claim
39 words
An adjuvant vaccine composition comprising a physiologically acceptable injectable oil, an antigen and from about 0.5 to 10% by volume of stabilizer consisting essentially of aluminum monostearate, the aluminum monostearate being essentially free of any other fatty acid radical.
Claim 8
Dependent Claim
14 words
The adjuvant vaccine composition of claim 5 wherein the oil is a vegetable oil.
Claim 9
Dependent Claim
14 words
The adjuvant vaccine composition of claim 5 wherein the oil is a mineral oil.
Claim 10
Dependent Claim
13 words
The adjuvant composition of claim 6 wherein the vegetable oil is peanut oil.
Claim 11
Dependent Claim
12 words
The adjuvant vaccine composition of claim 5 wherein the antigen is influenza.
Claim 12
Dependent Claim
12 words
The adjuvant vaccine composition of claim 6 wherein the antigen is influenza.
Claim 13
Dependent Claim
12 words
The adjuvant vaccine composition of claim 8 wherein the antigen is influenza.
References Cited (Backward Citations)
US3149036A
Cited
US3435112A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-16 | 1981-07-18 | 1982-01-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-16 | 1985-07-18 | 1986-01-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-16 | 1989-07-18 | 1990-01-17 | $7700.00 | Window Closed / Lapsed |