US4067984A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pyridylbutylamino ethylene compounds
Assignee: Smith Kline & French Laboratories Ltd
•
Filing: 1976-10-04
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Granted: 1978-01-10
•
Expires: 1996-10-04
Abstract
Abstract The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[4-(3-chloro-2-pyridyl)butylamino]ethylene.
Inventors
- 👤 Graham John Durant
- 👤 John Colin Emmett
- 👤 Charon Robin Ganellin
- 👤 Hunter Douglas Prain
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 04:41
CPC Classifications
C; C07; C07D; C07D275/00; C07D275/02; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/28; C07D213/32; C07D249/00; C07D249/02; C07D249/08; C07D261/00; C07D261/02; C07D261/06; C07D261/08; C07D285/00; C07D285/01; C07D285/02; C07D285/04; C07D285/08
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
110 words
A compound of the formula: ##STR8## wherein X and Y, which may be the same or different, are hydrogen, nitro, cyano or SO 2 Ar but are not both hydrogen; Het is a pyridine ring which ring is unsubstituted or substituted by lower alkyl, hydroxyl, halogen or amino; R is Het(CH 2 ) m Z(CH 2 ) n ; Z is sulphur or methylene; m is 0, 1 or 2 and n is 2 or 3 provided that the sum of m and n is 3 or 4, and Ar is phenyl which is unsubstituted or substituted by halogen, methyl or amino, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
110 words
A compound of the formula: ##STR8## wherein X and Y, which may be the same or different, are hydrogen, nitro, cyano or SO 2 Ar but are not both hydrogen; Het is a pyridine ring which ring is unsubstituted or substituted by lower alkyl, hydroxyl, halogen or amino; R is Het(CH 2 ) m Z(CH 2 ) n ; Z is sulphur or methylene; m is 0, 1 or 2 and n is 2 or 3 provided that the sum of m and n is 3 or 4, and Ar is phenyl which is unsubstituted or substituted by halogen, methyl or amino, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
16 words
A compound of claim 1 wherein R is Het CH 2 S--CH 2 CH 2 .
Claim 4
Dependent Claim
20 words
A compound of claim 1 wherein Het is 2-pyridine substituted in the 3 position by chloro, bromo, hydroxy or amino.
Claim 5
Dependent Claim
13 words
A compound of claim 1 wherein X is nitro and Y is hydrogen.
Claim 6
Dependent Claim
10 words
A compound of claim 1 said compound being 1-nitro-2-[4-(3-chloro-2-pyridyl)butylamino]-2-[2-((3-chloro-2-pyridyl)methylthio)ethylamino] ethylene.
Claim 7
Dependent Claim
26 words
A pharmaceutical composition to inhibit H-2 histamine receptors comprising a pharmaceutical carrier and, in an effective amount to inhibit said receptors, a compound of claim 1.
Claim 8
Dependent Claim
32 words
A method of inhibiting H-2 histamine receptors which comprises administering orally or parenterally to an animal in need thereof, in an effective amount to inhibit said receptors, a compound of claim 1.
References Cited (Backward Citations)
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US3734924A
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US3905984A
Cited
US3876647A
Cited
US3920822A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-09 | 1981-07-11 | 1982-01-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-09 | 1985-07-11 | 1986-01-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-09 | 1989-07-11 | 1990-01-10 | $7700.00 | Window Closed / Lapsed |