Patent US4067960A successfully refreshed from Google Patents.
US4067960A
Expired / Lapsed
US
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Pharmaceutical compositions containing cardiac glycoside
Assignee: Catalent UK Swindon Encaps Ltd
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Filing: 1976-12-01
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Granted: 1978-01-10
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Expires: 1996-12-01
Abstract
Abstract A cardiotonic dosage unit form comprises a soft gelatine capsule containing a liquid cardiotonic composition comprising (a) a cardiac glycoside, preferably digitoxin or digoxin; (b) dimethyl formamide or dimethyl acetamide; and (c) a liquid polyethylene glycol and also, optionally, (d) propylene glycol or glycerin. The weight ratio of dimethyl acetamide or dimethyl formamide to cardiac glyceride is preferably at least 5:1 and the polyethylene glycol preferably forms at least 75% by weight of the total composition contained in the gelatine capsule.
Inventors
- 👤 Carlo Fadda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 15:38
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/4841; A61K9/4858; A61K31/00; A61K31/70; A61K31/7042; A61K31/7048
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
94 words
A cardiotonic dosage unit form comprising a soft elastic gelatin capsule containing a solution of (a) about 50 - 300 micrograms of a digitalis cardiac glycoside including digoxin, digitoxin, digitalin, lanatoside C, acetyl digitoxin, acetyl digoxin or methyl digoxin, (b) dimethyl formamide or dimethyl acetamide, the weight ratio of dimethyl acetamide or dimethyl formamide to said cardiac glycoside being at least 5:1 and (c) liquid polyethylene glycol comprising at least 75% by weight of the total solution contained in said gelatin capsule, the total solution having a weight of about 100 - 300 milligrams.
Claim 2
Dependent Claim
94 words
A cardiotonic dosage unit form comprising a soft elastic gelatin capsule containing a solution of (a) about 50 - 300 micrograms of a digitalis cardiac glycoside including digoxin, digitoxin, digitalin, lanatoside C, acetyl digitoxin, acetyl digoxin or methyl digoxin, (b) dimethyl formamide or dimethyl acetamide, the weight ratio of dimethyl acetamide or dimethyl formamide to said cardiac glycoside being at least 5:1 and (c) liquid polyethylene glycol comprising at least 75% by weight of the total solution contained in said gelatin capsule, the total solution having a weight of about 100 - 300 milligrams.
Claim 3
Dependent Claim
10 words
The composition of claim 1 including propylene glycol or glycerin.
Claim 4
Dependent Claim
11 words
The composition of claim 1 wherein said cardiac glycoside is digoxin.
Claim 5
Dependent Claim
11 words
The composition of claim 1 wherein said cardiac glycoside is digitoxin.
Claim 6
Dependent Claim
24 words
The composition of claim 1 wherein the weight ratio of dimethyl acetamide or dimethyl formamide to said cardiac glycoside is about 5:1 to 15:1.
Claim 7
Dependent Claim
19 words
The composition of claim 1 wherein said polyethylene glycol forms about 80 - 95% by weight of said solution.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-09 | 1981-07-11 | 1982-01-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-09 | 1985-07-11 | 1986-01-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-09 | 1989-07-11 | 1990-01-10 | $7700.00 | Window Closed / Lapsed |