Abstract Novel pharmacologically important organic germanium compounds (3-hydroxygermyl propionic acid salts) represented by the formula ##STR1## WHEREIN Met is a monovalent cation selected from the group consisting of Na, K, NH 4 , and NH 2 (CH 3 ) 2 , or divalent cation selected from the group consisting of Ca and Mg, and wherein x is 1 when Met is a monovalent cation and x is 2 when Met is a divalent cation. These compounds possess valuable therapeutic properties for treating such physiological abnormalities as psychiatric and neurological disorders, metabolic disorder, cardivascular disorder, disorder of digestive organs, skin disease, allergic disease, Kidney dysfunction, hepatic dysfunction, obstetric and pediatric diseases, etc., and the process for preparing thereof.
A compound of the formula ##STR4## wherein Met is a monovalent cation selected from the group consisting of Na, K, NH 4 , and NH 2 (CH 3 ) 2 , or a divalent cation selected from the group consisting of Ca and Mg, and wherein x is 1 when Met is a monovalent cation and x is 2 when Met is a divalent cation.
Claim 2
Dependent Claim
65 words
A compound of the formula ##STR4## wherein Met is a monovalent cation selected from the group consisting of Na, K, NH 4 , and NH 2 (CH 3 ) 2 , or a divalent cation selected from the group consisting of Ca and Mg, and wherein x is 1 when Met is a monovalent cation and x is 2 when Met is a divalent cation.
Claim 3
Dependent Claim
13 words
The compound of claim 1 wherein Met is Na and x is 1.
Claim 4
Dependent Claim
13 words
The compound of claim 1 wherein Met is Mg and x is 2.
Claim 5
Dependent Claim
13 words
The compound of claim 1 wherein Met is Ca and x is 2.
Claim 6
Dependent Claim
95 words
A process for preparing the compound of claim 1, which process comprises reacting trichlorogermanium with acrylic acid to thereby obtain 3-trichlorogermyl propionic acid of the formula ##STR5## hydrolyzing said acid with caustic alkali solution followed by acidification to thereby obtain 3-germylpropionic acid oxide of the formula (Ge--CH.sub.2 --CH.sub.2 --CO.sub.2 H).sub.2n O.sub.3n, wherein n=1, 2 or 3, and reacting said oxide with a hydroxide of the metal Met, wherein Met is the cation Na, K, NH 4 , NH 2 (CH 3 ) 2 , Ca, or Mg, to thereby form the compound of claim 6.