US4066648A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Isochroman derivatives
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1976-05-28
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Granted: 1978-01-03
•
Expires: 1996-05-28
Abstract
Abstract New isochroman derivatives which may be represented by general formula [I] ##STR1## wherein R 1 is hydrogen atom, a lower alkoxy group or hydroxyl group and R 2 is a lower alkoxy group or hydroxyl group; R 1 and R 2 may also be, connecting with each other, alkylenedioxy group; R 3 is a hydrogen atom, a lower alkyl or aralkyl group and R 4 is a lower alkyl or aralkyl group; R 3 and R 4 may also be groups which, taken together with the adjacent nitrogen atom, form a cyclic amino group; n means 1 or 2, and pharmacologically acceptable salt thereof have antidepressant, analgesic, diuretic, anti-inflammatory, muscle relaxing, vasodilator, hypotensive and other pharmacologic activities for mammals.
Inventors
- 👤 Yoshikazu Oka
- 👤 Akio Miyake
- 👤 Norio Tada
- 👤 Katsumi Itoh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 15:02
CPC Classifications
C; C07; C07D; C07D493/00; C07D493/02; C07D493/04; C07D311/00; C07D311/02; C07D311/76
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
57 words
A compound of the formula ##STR57## wherein R 1 ia hydrogen, lower alkoxy or hydroxyl and R 2 is lower alkoxy or hydroxyl of R 1 and R 2 when taken together form alkylenedioxy; R 3 is pyridyl, 3 or 4-chlorophenyl, 4-methoxyphenyl, 3,4-dimethoxyphenyl, 3,4,5-trimethoxyphenyl or phenyl and n is 1 or 2 or pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
57 words
A compound of the formula ##STR57## wherein R 1 ia hydrogen, lower alkoxy or hydroxyl and R 2 is lower alkoxy or hydroxyl of R 1 and R 2 when taken together form alkylenedioxy; R 3 is pyridyl, 3 or 4-chlorophenyl, 4-methoxyphenyl, 3,4-dimethoxyphenyl, 3,4,5-trimethoxyphenyl or phenyl and n is 1 or 2 or pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
9 words
A compound claimed in claim 1, which is 5,6-dimethoxy-1-[4-(2-pyridyl)piperazinylmethyl]-isochroman.
Claim 4
Dependent Claim
9 words
A compound claimed in claim 1, which is 6,7-dimethoxy-1-[4-(2-pyridyl)piperazinylmethyl]-isochroman.
Claim 5
Dependent Claim
9 words
A compound claimed in claim 1, which is 6-methoxy-1-[4-(2-pyridyl)piperazinylmethyl]-isochroman.
Claim 6
Dependent Claim
9 words
A compound claimed in claim 1, which is 5,8-dimethoxy-1-[4-(2-pyridyl)piperazinylmethyl]-isochroman.
Claim 7
Dependent Claim
9 words
A compound claimed in claim 1, which is 6,7-dimethoxy-1-{2-[4-(2-pyridyl)piperazinyl]-ethyl}-isochroman.
Claim 8
Dependent Claim
9 words
A compound claimed in claim 1, which is 5,6-dimethoxy-1-{2-[4-(2-pyridyl)piperazinyl]ethyl}-isochroman.
Claim 9
Dependent Claim
9 words
A compound claimed in claim 1, which is 6,7-methylenedioxy-1-{2-[4-(2-pyridyl)piperazinyl]-ethyl}-isochroman.
Claim 10
Dependent Claim
9 words
A compound claimed in claim 1, which is 6,7-methylenedioxy-1-[4-(2-pyridyl)-piperazinyl]-methylisochroman.
Claim 11
Dependent Claim
11 words
A compound claimed in claim 1, wherein R 3 represents phenyl.
Claim 12
Dependent Claim
9 words
A compound claimed in claim 1, which is 5,6-dimethoxy-1-(4-phenylpiperazinyl)methylisochroman.
Claim 13
Dependent Claim
9 words
A compound claimed in claim 1, which is 6-methoxy-1-(4-phenylpiperazinyl)methylisochroman.
Claim 14
Dependent Claim
9 words
A compound claimed in claim 1, which is 6,7-dimethoxy-1-[2-(4-phenylpiperazinyl)ethyl]-isochroman.
Claim 15
Dependent Claim
9 words
A compound claimed in claim 1, which is 5,6-dimethoxy-1-[2-(4-phenylpiperazinyl)ethyl]-isochroman.
Claim 16
Dependent Claim
9 words
A compound claimed in claim 1, which is 6,7-methylenedioxy-1-[2-(4-phenylpiperazinyl)-ethyl]-isochroman.
Claim 17
Dependent Claim
11 words
A compound claimed in claim 1, wherein R 3 represents 3-chlorophenyl.
Claim 18
Dependent Claim
9 words
A compound claimed in claim 1, which is 6,7-dimethoxy-1-{2-[4-(3-chlorophenyl)piperazinyl]ethyl}isochroman.
Claim 19
Dependent Claim
9 words
A compound claimed in claim 1, which is 5,6-dimethoxy-1-{2-[4-(3-chlorophenyl)piperazinyl]ethyl}isochroman.
Claim 20
Dependent Claim
10 words
A compound claimed in claim 1, which is 5,6-dimethoxy 1-[4-(3-chlorophenyl)piperazinylmethyl]isochroman.
Claim 21
Dependent Claim
11 words
A compound claimed in claim 1, wherein R 3 represents 4-chlorophenyl.
Claim 22
Dependent Claim
9 words
A compound claimed in claim 1, which is 6,7-dimethoxy-1-{2-[4-(4-chlorophenyl)piperazinyl]ethyl}isochroman.
Claim 23
Dependent Claim
9 words
A compound claimed in claim 1, which is 5,6-dimethoxy-1-{2-[4-(4-chlorophenyl)piperazinyl]ethyl}isochroman.
Claim 24
Dependent Claim
10 words
A compound claimed in claim 1, which is 5,6-dimethoxy 1-[4-(4-chlorophenyl)piperazinylmethyl]isochroman.
Claim 25
Dependent Claim
11 words
A compound of the formula: ##STR58## and pharmaceutically acceptable salts thereof.
Claim 26
Dependent Claim
11 words
A compound of the formula: ##STR58## and pharmaceutically acceptable salts thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-02 | 1981-07-04 | 1982-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-02 | 1985-07-04 | 1986-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-02 | 1989-07-04 | 1990-01-03 | $7700.00 | Window Closed / Lapsed |