Substituted isochromans and processes therefor

Abstract

Abstract AMINO-SUBSTITUTED 1-PHENYL ISOCHROMANS OF THE FORMULA 1-(R-C6H4-),R1,R2,R3,Q-ISOCHROMAN WHEREIN R IS HYDROGEN, LOWER ALKYL, HALOGEN, TRIFLUOROMETHYL, AMINO, N-LOWER ALKYLAMINO OR N,N-DI-LOWER ALKYLAMINO; R1 IS HYDROGEN OR LOWER ALKYL, R2 AND R3 ARE EACH HYDROGEN, LOWER ALKYL, LOWER ALKOXY, HYDROXY, HALOGEN OR TRIFLUOROMETHYL AND Q IS A RADICAL ATTACHED TO EITHER THE 3 OR 4 POSITION, HAVING THE STRUCTURE -(CH2)M-N(-R4)-R5 WHEREIN R4 AND R5 ARE INDEPENDENTLY HYDROGEN, LOWER ALKYL OR HYDROXY-LOWER ALKYL OR, WHEN TAKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED, FORM A 5OR 6-MEMBERED NITROGEN-CONTAINING RING HAVING FROM 3 TO 5 CARBON ATOMS IN THE RING, ONE OF WHICH MAY BE REPLACED BY AN OXYGEN ATOM, M IS ZERO TO 4 AND WHEN M IS 1 OR MORE, THE ALKYLENE CHAIN MAY CONTAIN A SUBSTITUENT METHYL GROUP; AND SALTS THEREOF. PROCESSES FOR THE PREPARATION OF SAID INTERMEDIATE COMPOUNDS AND FINAL PRODUCTS ARE DISCLOSED. THE FINAL PRODUCTS OF THE INVENTION HAVE UTILITY AS CNS-ACTIVE AGENTS, E.G. ANTICONVULSANTS, ANTIDEPRESSANTS AND ANORECTIC AGENTS.

Inventors

• 👤 N Sugisaka
• 👤 M Klohs
• 👤 F Petracek

Bibliographic Details