Patent US4064343A successfully refreshed from Google Patents.
US4064343A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-Halo cephalosporins
Assignee: Eli Lilly and Co
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Filing: 1976-02-09
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Granted: 1977-12-20
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Expires: 1996-02-09
Abstract
Abstract 7-Acylamido- and 7-amino-3-halo-3-cephem-4-carboxylic acids, esters and pharmaceutically-acceptable salts and esters thereof are new cephalosporin compounds provided by the reaction of a 7-acylamido-3-hydroxy-3-cephem-4-carboxylic acid ester or a 7-amino-3-hydroxy-3-cephem-4-carboxylic acid ester with an iodinating, fluorinating, chlorinating, or brominating reagent. For example, 7-amino-3-chloro-3-cephem-4-carboxylic acid and 7-phenoxyacetamido-3-chloro-3-cephem-4-carboxylic acid are provided. The 7-acylamido-3-halo cephalosporin acids and pharmaceutically acceptable salts and esters provided are valuable antibiotic compounds having desirable therapeutic properties.
Inventors
- 👤 Robert R. Chauvette
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:28
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/59; C07D501/18
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
39 words
A compound of the formula ##STR48## wherein R 1 is hydrogen, benzyl, p-methoxybenzyl, p-nitrobenzyl, diphenylmethyl, 2,2,2-trichloroethyl, t-butyl or a pharmaceutically acceptable ester group of the formula ##STR49## X is fluoro, chloro, bromo or iodo; and the hydrochloride salts thereof.
Claim 2
Dependent Claim
39 words
A compound of the formula ##STR48## wherein R 1 is hydrogen, benzyl, p-methoxybenzyl, p-nitrobenzyl, diphenylmethyl, 2,2,2-trichloroethyl, t-butyl or a pharmaceutically acceptable ester group of the formula ##STR49## X is fluoro, chloro, bromo or iodo; and the hydrochloride salts thereof.
Claim 3
Dependent Claim
9 words
The compound of claim 1 wherein X is chloro.
Claim 4
Dependent Claim
10 words
The compound of claim 2 said compound being 7-amino-3-chloro-3-cephem-4-carboxylic acid.
Claim 5
Dependent Claim
10 words
The compound of claim 2 said compound being p-nitrobenzyl 7-amino-3-chloro-3-cephem-4-carboxylate.
Claim 6
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 4.
Claim 7
Dependent Claim
10 words
The compound of claim 2 said compound being diphenylmethyl 7-amino-3-chloro-3-cephem-4-carboxylate.
Claim 8
Dependent Claim
9 words
The compound of claim 1 wherein X is fluoro.
Claim 9
Dependent Claim
9 words
The compound of claim 1 wherein X is bromo.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-19 | 1981-06-20 | 1981-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-19 | 1985-06-20 | 1985-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-19 | 1989-06-20 | 1989-12-20 | $7700.00 | Window Closed / Lapsed |