Patent GB1069656A successfully refreshed from Google Patents.
Patent US4064230A successfully refreshed from Google Patents.
US4064230A
Expired / Lapsed
US
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Polyenic macrolide compositions
Assignee: London International Us Holdings Inc
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Filing: 1976-10-08
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Granted: 1977-12-20
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Expires: 1996-10-08
Abstract
Abstract A method of increasing the overall effectiveness, including stability and gastrointestinal tolerability, of a polyenic macrolide selected from the class consisting of candicidin, fungimycin, hamycin and mediocidin is described which comprises orally administering the polyenic macrolide with an absorbent material. Compositions containing a polyenic macrolide and a suitable absorbent material preferably in beadlet form are described for use in treating various conditions including prostate hypertrophy, hypercholesterolemia and acne.
Inventors
- 👤 Harry W. Gordon
- 👤 Carl P. Schaffner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 05:38
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K9/00; A61K9/14; A61K9/141; A61K9/143; A61K9/48; A61K9/4841; A61K9/485; A61K9/50; A61K9/5073; A61K9/5078; E; E02; E02F; E02F9/00; E02F9/20; E02F9/22; E02F9/2264; E02F9/2275
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
86 words
A composition comprising a capsule containing a multiplicity of beadlets, said beadlets together comprising (1) about 25 milligrams to about 100 milligrams of a polyenic macrolide selected from the class consisting of hamycin and mediocidin and (2) an absorbent material which binds with said polyenic macrolide in a substantially acidic pH environment and loses its affinity for said polyenic macrolide in a substantially neutral pH environment, the ratio of said polyenic macrolide to said absorbent material being about 1 to 2 to about 1 to 8.
Claim 2
Dependent Claim
86 words
A composition comprising a capsule containing a multiplicity of beadlets, said beadlets together comprising (1) about 25 milligrams to about 100 milligrams of a polyenic macrolide selected from the class consisting of hamycin and mediocidin and (2) an absorbent material which binds with said polyenic macrolide in a substantially acidic pH environment and loses its affinity for said polyenic macrolide in a substantially neutral pH environment, the ratio of said polyenic macrolide to said absorbent material being about 1 to 2 to about 1 to 8.
Claim 3
Dependent Claim
54 words
A solid composition according to claim 1 wherin said absorbent material is selected from the group consisting of non-toxic inorganic material whose cation portion is selected from the class consisting of a divalent and trivalent metal and whose anion portion is selected from the group consisting of a carbonate, phosphate, silicate, sulphate and hydroxide.
Claim 4
Dependent Claim
22 words
A solid composition according to claim 1 wherein said cation is selected from the group consisting of calcium, magnesium, iron and aluminum.
Claim 5
Dependent Claim
17 words
A composition according to claim 1 wherein said polyenic macrolide is coated with a sustained release coating.
Claim 6
Dependent Claim
18 words
A solid composition according to claim 4 wherein said beadlets are contained in a hard gelatin shell capsule.
Claim 7
Dependent Claim
24 words
A solid composition according to claim 5 which includes an acidic material for maintaining the pH of said composition between about 6.5 and 7.5.
Claim 8
Dependent Claim
60 words
A formulation comprising a hard shell capsule containing a multiplicity of beadlets, said beadlets together comprising (1) about 25 to 100 milligrams of mediocidin, and (2) about 50 to about 400 milligrams of calcium carbonate, the ratio of mediocidin to calcium carbonate being no greater than about 1 to 2, said formulation having a pH between about 6.5 and 7.5.
Claim 9
Dependent Claim
60 words
A formulation comprising a hard shell capsule containing a multiplicity of beadlets, said beadlets together comprising (1) about 25 to 100 milligrams of mediocidin, and (2) about 50 to about 400 milligrams of calcium carbonate, the ratio of mediocidin to calcium carbonate being no greater than about 1 to 2, said formulation having a pH between about 6.5 and 7.5.
Claim 10
Dependent Claim
17 words
A solid formulation according to claim 7 wherein said mediocidin is coated with a sustained release coating.
Claim 11
Dependent Claim
16 words
A solid composition according to claim 8 wherein said sustained release coating is an enteric coating.
Claim 12
Dependent Claim
11 words
A composition according to claim 7 which includes a potassium phosphate.
Claim 13
Dependent Claim
61 words
A formulation comprising a hard shell capsule containing a multiplicity of beadlets, said beadlets together comprising (1) about 25 to about 100 milligrams of hamycin, and (2) about 50 to about 400 milligrams of calcium carbonate, the ratio of hamycin to calcium carbonate being no greater than about 1 to 2, said formulation having a pH between about 6.5 and 7.5.
Claim 14
Dependent Claim
61 words
A formulation comprising a hard shell capsule containing a multiplicity of beadlets, said beadlets together comprising (1) about 25 to about 100 milligrams of hamycin, and (2) about 50 to about 400 milligrams of calcium carbonate, the ratio of hamycin to calcium carbonate being no greater than about 1 to 2, said formulation having a pH between about 6.5 and 7.5.
Claim 15
Dependent Claim
17 words
A solid formulation according to claim 11 wherein said hamycin is coated with a sustained release coating.
Claim 16
Dependent Claim
16 words
A solid composition according to claim 12 wherein said sustained release coating is an enteric coating.
Claim 17
Dependent Claim
11 words
A composition according to claim 12 which includes a potassium phosphate.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-19 | 1981-06-20 | 1981-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-19 | 1985-06-20 | 1985-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-19 | 1989-06-20 | 1989-12-20 | $7700.00 | Window Closed / Lapsed |