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US4064120A
Expired / Lapsed
US
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3,3-Dichloro-2-azetidinone derivatives having antiinflammatory activity
Assignee: ER Squibb and Sons LLC
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Filing: 1976-11-01
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Granted: 1977-12-20
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Expires: 1996-11-01
Abstract
Abstract Compounds having the formula ##STR1## wherein R 1 is alkyl, cycloalkyl or aryl; R 2 is dialkylamino or a nitrogen containing heterocyclic group; A 1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A 2 is an alkylene group having 2 to 5 carbon atoms; have antiinflammatory activity.
Inventors
- 👤 John Krapcho
- 👤 Chester F. Turk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:44
CPC Classifications
C; C07; C07D; C07D205/00; C07D205/02; C07D205/06; C07D205/08; A; A61; A61P; A61P29/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
92 words
A compound having the formula ##STR5## or a pharmaceutically acceptable salt thereof, wherein R 1 is alkyl, cycloalkyl or aryl; R 2 is dialkylamino; A 1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A 2 is an alkylene group having 2 to 5 carbon atoms; wherein aryl is phenyl or phenyl mono substituted with a halogen, alkyl, alkoxy, trifluoromethyl, or nitro group; alkyl and alkoxy are groups having 1 to 6 carbon atoms; and cycloalkyl is a group having 3 to 7 carbon atoms.
Claim 2
Dependent Claim
92 words
A compound having the formula ##STR5## or a pharmaceutically acceptable salt thereof, wherein R 1 is alkyl, cycloalkyl or aryl; R 2 is dialkylamino; A 1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A 2 is an alkylene group having 2 to 5 carbon atoms; wherein aryl is phenyl or phenyl mono substituted with a halogen, alkyl, alkoxy, trifluoromethyl, or nitro group; alkyl and alkoxy are groups having 1 to 6 carbon atoms; and cycloalkyl is a group having 3 to 7 carbon atoms.
Claim 3
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is alkyl.
Claim 4
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is aryl.
Claim 5
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 1 is phenyl.
Claim 6
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 2 is dialkylamino.
Claim 7
Dependent Claim
13 words
The compound in accordance with claim 1 having the name 3,3-dichloro-4-[2-[3-(dimethylamino)propoxyl]phenyl]-1-(2-phenylethyl)2-azetidinone, hydrochloride (1:1).
Claim 8
Dependent Claim
14 words
The compound in accordance with claim 1 having the name 3,3-dichloro-4-[2-[3-(dimethylamino)propoxyl]phenyl]-1-(phenylmethyl)-2-azetidinone, oxalate salt (1:1).
Claim 9
Dependent Claim
13 words
The compound in accordance with claim 1 having the name 1-butyl-3,3-dichloro-4-[2-[3-(dimethylamino)propoxy]phenyl]-2-azetidinone, hydrochloride (1:1).
Claim 10
Dependent Claim
13 words
The compound in accordance with claim 1 having the name 3,3-dichloro-4-[4-[3-(dimethylamino)propoxy]phenyl]-1-(2-phenylethyl)-2-azetidinone, hydrochloride (1:1).
Claim 11
Dependent Claim
13 words
The compound in accordance with claim 1 having the name 3,3-dichloro-4-[2-[3-(dimethylamino)propoxy]phenyl]-1-phenyl-2-azetidinone, hydrochloride (1:1).
References Cited (Backward Citations)
US3194801A
Cited
US3481920A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-19 | 1981-06-20 | 1981-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-19 | 1985-06-20 | 1985-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-19 | 1989-06-20 | 1989-12-20 | $7700.00 | Window Closed / Lapsed |