US4062966A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-Aryl-2-(1-imidazolyl) alkyl ethers and thioethers
Assignee: Pfizer Inc
•
Filing: 1976-04-12
•
Granted: 1977-12-13
•
Expires: 1996-04-12
Abstract
Abstract Novel 1-aryl-2-(1-imidazolyl)alkyl ethers and thioethers having anti-fungal properties are disclosed.
Inventors
- 👤 Geoffrey E. Gymer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 11:27
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/02; C07D231/10; C07D231/12; A; A61; A61P; A61P31/00; A61P31/04; C07D233/00; C07D233/54; C07D233/56; C07D249/00; C07D249/02; C07D249/08
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
109 words
A 1-aryl-2-(1-imidazolyl)alkyl ether or thioether having the formula: ##STR12## and the pharmaceutically acceptable acid addition salts thereof wherein R 1 , R 2 , R 3 and R 4 are each hydrogen or alkyl of from 1 to 6 carbon atoms; Ar is phenyl, substituted phenyl, said substituents being halogen, alkyl of from 1 to 6 carbon atoms or alkoxy of from 1 to 6 carbon atoms, thienyl or halothienyl; Z is oxygen or sulfur; n is 1 or 2; and Y is thienyl or substituted thienyl group, said substituents being halogen, alkyl of from 1 to 6 carbon atoms or alkoxy of from 1 to 6 carbon atoms.
Claim 2
Dependent Claim
109 words
A 1-aryl-2-(1-imidazolyl)alkyl ether or thioether having the formula: ##STR12## and the pharmaceutically acceptable acid addition salts thereof wherein R 1 , R 2 , R 3 and R 4 are each hydrogen or alkyl of from 1 to 6 carbon atoms; Ar is phenyl, substituted phenyl, said substituents being halogen, alkyl of from 1 to 6 carbon atoms or alkoxy of from 1 to 6 carbon atoms, thienyl or halothienyl; Z is oxygen or sulfur; n is 1 or 2; and Y is thienyl or substituted thienyl group, said substituents being halogen, alkyl of from 1 to 6 carbon atoms or alkoxy of from 1 to 6 carbon atoms.
Claim 3
Dependent Claim
15 words
A compound as claimed in claim 1 in which Ar is phenyl or substituted phenyl.
Claim 4
Dependent Claim
12 words
A compound as claimed in claim 1 in which Z is oxygen.
Claim 5
Dependent Claim
12 words
A compound as claimed in claim 1 in which Z is sulfur.
Claim 6
Dependent Claim
25 words
A compound as claimed in claim 1 in which R 1 , R 2 , R 3 and R 4 are each a hydrogen atom.
Claim 7
Dependent Claim
14 words
A compound as claimed in claim 2 in which Ar is a 2,4-dichlorophenyl group.
Claim 8
Dependent Claim
12 words
A compound as claimed in claim 1 in which n is 1.
Claim 9
Dependent Claim
16 words
A compound as claimed in claim 1 in which Y is a thienyl or halothienyl group.
Claim 10
Dependent Claim
1 words
1-[2,4-dichloro-β-(3-thienylmethoxy)phenethyl]imidazole.
Claim 11
Dependent Claim
1 words
1-[2,4-dichloro-β-(3-thienylmethoxy)phenethyl]imidazole.
Claim 12
Dependent Claim
1 words
1-[2,4-dichloro-β-(5-chloro-2-thienylmethoxy)phenethyl]imidazole.
Claim 13
Dependent Claim
1 words
1-[2,4-dichloro-β-(5-chloro-2-thienylmethoxy)phenethyl]imidazole.
Claim 14
Dependent Claim
1 words
1-[2,4-dichloro-β-(2-chloro-3-thienylmethoxy)phenethyl]imidazole.
Claim 15
Dependent Claim
1 words
1-[2,4-dichloro-β-(2-chloro-3-thienylmethoxy)phenethyl]imidazole.
Claim 16
Dependent Claim
1 words
1-[2,4-dichloro-β-(2-thienylmethoxy)phenethyl]imidazole.
Claim 17
Dependent Claim
1 words
1-[2,4-dichloro-β-(2-thienylmethoxy)phenethyl]imidazole.
Claim 18
Dependent Claim
1 words
1-[2,4-dichloro-β-(2,5-dichloro-3-thienylmethoxy)phenethyl]imidazole.
Claim 19
Dependent Claim
1 words
1-[2,4-dichloro-β-(2,5-dichloro-3-thienylmethoxy)phenethyl]imidazole.
Claim 20
Dependent Claim
1 words
1-[2,4-dichloro-β-(5-chloro-2-thienylmethylthio)phenethyl]imidazole.
Claim 21
Dependent Claim
1 words
1-[2,4-dichloro-β-(5-chloro-2-thienylmethylthio)phenethyl]imidazole.
Claim 22
Dependent Claim
1 words
1-[2,4-dichloro-β-(3-thienylmethylthio)phenethyl]imidazole.
Claim 23
Dependent Claim
1 words
1-[2,4-dichloro-β-(3-thienylmethylthio)phenethyl]imidazole.
Claim 24
Dependent Claim
2 words
1-[2-(5-chloro-2-thienyl)-2-(3-chloro-2-thienylmethoxy)ethyl] imidazole.
Claim 25
Dependent Claim
2 words
1-[2-(5-chloro-2-thienyl)-2-(3-chloro-2-thienylmethoxy)ethyl] imidazole.
Claim 26
Dependent Claim
34 words
A composition in dosage unit form useful for the treatment of fungal infections comprising a pharmaceutical carrier containing from about 10 mg. to about 3,000 mg. of a compound as claimed in claim 1.
Claim 27
Dependent Claim
34 words
A method of treating fungal infections in animals which comprises parentally or orally administering to an animal in need of such treatment an antifungal effective amount of a compound as claimed in claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-12 | 1981-06-13 | 1981-12-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-12 | 1985-06-13 | 1985-12-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-12 | 1989-06-13 | 1989-12-13 | $7700.00 | Window Closed / Lapsed |