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US4062831A
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Copolymers based on N-substituted acrylamides, N-substituted methacrylamides and N,N-disubstituted acrylamides and the method of their manufacturing
Assignee: Czech Academy of Sciences
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Filing: 1975-04-17
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Granted: 1977-12-13
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Expires: 1995-04-17
Abstract
Abstract The invention relates to copolymers based on N-substituted acrylamides, N-substituted methacrylamides and N,N-disubstituted acrylamides and to a method for their manufacturing, which copolymers are prepared under conditions when the phase separation takes place. The resulting copolymer contains reactive groups and serves as the intermediate for preparation of biologically active compounds (enzymes, hormones, drugs, etc.) bonded to the polymer. The procedure according to the invention enables to prepare porous polymers suitable as separation barriers (membranes) or column packings for gel or affinity chromatography, if the polymerization is carried out in the presence of a divinyl component.
Inventors
- 👤 Jinrich Kopecek
- 👤 Karel Ulbrich
- 👤 Jiri Vacik
- 👤 Jiri Strohalm
- 👤 Vladimir Chytry
- 👤 Jaroslav Drobnik
- 👤 Jaroslav Kalal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 15:39
CPC Classifications
C; C08; C08F; C08F220/00; C08F220/02; C08F220/52; C08F220/54
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
121 words
A copolymer consisting of: 1. 39.9 to 99.9 molar percent of a first monomeric component consisting of: a. 100 to 75 molar percent of a monomer comprising an N-monosubstituted acrylamide or methacrylamide or an N,N-disubstituted methacrylamide, each N-substituent being an alkyl or an alkyloxyalkyl group having 1 to 6 carbon atoms and 0 to 3 hydroxy groups; and b. 0 to 25 molar percent of a monovinylic monomer other than (a); and 2. a minor molar percent proportion of a second monomeric component having the general formula: ##STR6## wherein: R 4 is H or CH 3 ; R 5 is the radical form of p-nitrophenol, 2,3,5-trichlorophenol, 8-hydroxyquinoline, N-hydroxysuccinimide, or N-hydroxyphthalimide; n is 0 to 4; and x is 1 to 10.
Claim 2
Dependent Claim
121 words
A copolymer consisting of: 1. 39.9 to 99.9 molar percent of a first monomeric component consisting of: a. 100 to 75 molar percent of a monomer comprising an N-monosubstituted acrylamide or methacrylamide or an N,N-disubstituted methacrylamide, each N-substituent being an alkyl or an alkyloxyalkyl group having 1 to 6 carbon atoms and 0 to 3 hydroxy groups; and b. 0 to 25 molar percent of a monovinylic monomer other than (a); and 2. a minor molar percent proportion of a second monomeric component having the general formula: ##STR6## wherein: R 4 is H or CH 3 ; R 5 is the radical form of p-nitrophenol, 2,3,5-trichlorophenol, 8-hydroxyquinoline, N-hydroxysuccinimide, or N-hydroxyphthalimide; n is 0 to 4; and x is 1 to 10.
Claim 3
Dependent Claim
19 words
A copolymer according to claim 1, in which, in the formula of the second monomeric component, x is 1.
Claim 4
Dependent Claim
18 words
A copolymer according to claim 1, in which monomer (a) of the first monomeric component comprises N-(2-hydroxypropyl) methacrylamide.
Claim 5
Dependent Claim
20 words
A copolymer according to claim 1, in which the monovinylic monomer (b) of the first monomeric component comprises 2-hydroxyethyl methacrylate.
Claim 6
Dependent Claim
50 words
A method of producing a copolymer according to claim 1, which comprises copolymerizing the monomeric components by means of free-radical polymerization in a 2 - 75% solution of a low-molecular-weight precipitant, the interaction parameter polymer - low-molecular-weight precipitant being higher than 0.6, at a temperature of -10° to 100° C.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-12 | 1981-06-13 | 1981-12-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-12 | 1985-06-13 | 1985-12-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-12 | 1989-06-13 | 1989-12-13 | $7700.00 | Window Closed / Lapsed |