US4062746A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Solid phase synthesis of protected peptides
Assignee: Wisconsin Alumni Research Foundation
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Filing: 1975-05-07
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Granted: 1977-12-13
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Expires: 1995-05-07
Abstract
Abstract The invention is addressed to the preparation of 3-nitro-4-bromomethyl benzoic acid, as a new compound from which 3-nitro-4-bromomethyl benzoyl amide polystyrene resin can be prepared for solid synthesis of protected peptide acids and amides and separation thereof without cleavage of acid labile protecting groups or decomposition of aromatic acid groups and from which purified polypeptides can be formed.
Inventors
- 👤 Daniel H. Rich
- 👤 Sweet K. Gurwara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 11:50
CPC Classifications
C; C07; C07C; C07C205/00; C07C205/49; C07C205/57; C07C205/58; C07K; C07K1/00; C07K1/04; C07K1/042; C07K7/00; C07K7/04; C07K7/23; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
49 words
The product having the general formula ##STR10## in which R is 0-8 carbon atoms in an alkyl or substituted alkyl group, X is NH, n is a number up to about 50 and the term amino acid denotes any one of the amino acids and peptides and mixtures thereof.
Claim 2
Dependent Claim
49 words
The product having the general formula ##STR10## in which R is 0-8 carbon atoms in an alkyl or substituted alkyl group, X is NH, n is a number up to about 50 and the term amino acid denotes any one of the amino acids and peptides and mixtures thereof.
Claim 3
Independent Claim
74 words
The method of producing the product having the general formula ##STR11## in which R is 0-8 carbon atoms in an alkyl or substituted alkyl group, X is 0, n is a number up to about 50, and the term amino acid denotes any one of the amino acids and peptides and mixtures thereof, comprising the step of reacting one or more protected amino acids or peptides with the compound having the general formula ##STR12##
Claim 4
Independent Claim
74 words
The method of producing the product having the general formula ##STR11## in which R is 0-8 carbon atoms in an alkyl or substituted alkyl group, X is 0, n is a number up to about 50, and the term amino acid denotes any one of the amino acids and peptides and mixtures thereof, comprising the step of reacting one or more protected amino acids or peptides with the compound having the general formula ##STR12##
Claim 5
Dependent Claim
24 words
The method of producing the product of claim 1 comprising the step of reacting one or more protected amino acids and peptides with ##STR13##
Claim 6
Dependent Claim
39 words
The method for release of fragments of peptides or amino acids from the product of claim 1 comprising subjecting the product to photolysis whereby the presence of the ortho-nitro benzyl amino group provides for clean separation of the fragments.
References Cited (Backward Citations)
US3700609A
Cited
US3573253A
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US3645996A
Cited
US3784523A
Cited
US3775378A
Cited
US3814732A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-12 | 1981-06-13 | 1981-12-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-12 | 1985-06-13 | 1985-12-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-12 | 1989-06-13 | 1989-12-13 | $7700.00 | Window Closed / Lapsed |