Reaction of halomethylated polymers with quaternary ammonium salts of protected amino acids
Abstract
Abstract WHEREIN R1, R2, R3, AND R4, TAKEN SEPARATELY, EACH REPRESENTS A MEMBER SELECTED FROM THE GROUP CONSISTING OF ALKYL HAVING 1 TO 18 CARBON ATOMS, CYCLOALKYL HAVING 5 TO 12 CARBON ATOMS, PHENYL, NAPHTHYL, ARALKYL HAVING 7 TO 16 CARBON ATOMS, R1 AND R2 TOGETHER WITH THE QUATERNARY NITROGEN ATOM FORM PIPERIDINYL OR MORPHINYL OR R1, R2 AND R3 TAKEN TOGETHER FORM PYRIDYL OR 2STYRYL-PYRIDYL. R-N(+)(-R1)(-R3)-R2 0H(-) THE PRESENT INVENTION RELATES TO A PROCESS FOR BINDING AN AMINO ACID HAVING AN AMINE PROTECTIVE GROUP FIXED ON THE AMINO GROUP TO A STYRENE-DIVINYLBENZE POLYMER CARRYING HALOMETHYL GROUPS, BY REACTING A SALT OF THE SO PROTECTED AMINO ACID WITH THE SAID HALOMETHYLATED STYRENE-DIVINYLBENZENE POLYMER IN AN INERT SOLVENT TO FORM AN AMINO ACID ESTER USEFUL IN SOLID PHASE PEPTIDE SYNTHESIS, WHEREBY THE SALT IS DISSOLVED IN SAID SOLVENT AND THE POLYMER IS SWELLED IN SAID SOLVENT, THE IMPROVEMENT WHEREIN THE SALT OF THE SAID PROTECTED AMINO ACID IS A SALT OF A QUATERNARY AMMONIUM HYDROXIDE OF THE FORMULA:
Inventors
- 👤 A Loffet
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-01-07 | 1977-07-09 | 1978-01-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-01-07 | 1981-07-09 | 1982-01-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-01-07 | 1985-07-09 | 1986-01-08 | $7700.00 | Window Closed / Lapsed |