Patent US3277743A successfully refreshed from Google Patents.
Patent US4061670A successfully refreshed from Google Patents.
US4061670A
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US
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15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners
Assignee: Wyeth Holdings LLC
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Filing: 1976-07-19
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Granted: 1977-12-06
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Expires: 1996-07-19
Abstract
Abstract This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.
Inventors
- 👤 Middleton Brawner Floyd, Jr.
- 👤 Martin Joseph Weiss
- 👤 Charles Vincent Grudzinskas
- 👤 Sow-Mei Lai Chen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:36
CPC Classifications
C; C07; C07C; C07C405/00; C07C405/0008; C07C405/0033; A; A61; A61P; A61P1/00; A61P15/00; A61P15/04; A61P25/00; A61P29/00; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804; C07F7/22; C07F7/2208
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
138 words
An optically active compound of the formula: ##STR25## or a racemic mixture of that formula and the mirror image thereof wherein R 1 is selected from the group consisting of hydrogen and alkyl having from 1 to 12 carbon atoms; R 2 is selected from the group consisting of alkyl having from 3 to 7 carbon atoms; R 3 is hydroxy; Y is a divalent moiety of the formulae: ##STR26## X is a divalent moiety selected from the group consisting of those of the formulae: ##STR27## wherein R 5 is selected from the group consisting of vinyl and cyclopropyl; Z is a divalent moiety of the formulae: ##STR28## wherein n is an integer from 3 to 5, inclusive; the moiety -C 13 -C 14 -is trans-vinylene; and the pharmacologically acceptable cationic salts thereof when R 1 is hydrogen.
Claim 2
Dependent Claim
138 words
An optically active compound of the formula: ##STR25## or a racemic mixture of that formula and the mirror image thereof wherein R 1 is selected from the group consisting of hydrogen and alkyl having from 1 to 12 carbon atoms; R 2 is selected from the group consisting of alkyl having from 3 to 7 carbon atoms; R 3 is hydroxy; Y is a divalent moiety of the formulae: ##STR26## X is a divalent moiety selected from the group consisting of those of the formulae: ##STR27## wherein R 5 is selected from the group consisting of vinyl and cyclopropyl; Z is a divalent moiety of the formulae: ##STR28## wherein n is an integer from 3 to 5, inclusive; the moiety -C 13 -C 14 -is trans-vinylene; and the pharmacologically acceptable cationic salts thereof when R 1 is hydrogen.
Claim 3
Dependent Claim
11 words
The optically active compound according to claim 1, l-9-oxo-11α,16-dihydroxy-16-vinyl-20-nor-5-cis, 13-trans-prostadienoic acid.
Claim 4
Dependent Claim
9 words
The racemic mixture according to claim 1, dl-9-oxo-11α,16-dihydroxy-16-vinyl-20-nor-5-cis,13-trans-prostadienoic acid.
Claim 5
Dependent Claim
11 words
The optically active compound according to claim 1, l-9-oxo-11α,16-dihydroxy-16-vinyl-20-methyl-5-cis, 13-trans-prostadienoic acid.
Claim 6
Dependent Claim
9 words
The racemic mixture according to claim 1, dl-9-oxo-11α,16-dihydroxy-16-vinyl-20-methyl-5-cis,13-trans-prostadienoic acid.
Claim 7
Dependent Claim
11 words
The optically active compound according to claim 1, l-9-oxo-11α,16-dihydroxy-16-vinyl-20-ethyl-5-cis, 13-trans-prostadienoic acid.
Claim 8
Dependent Claim
9 words
The racemic mixture according to claim 1, dl-9-oxo-11α,16-dihydroxy-16-vinyl-20-ethyl-5-cis,13-trans-prostadienoic acid.
Claim 9
Dependent Claim
45 words
The optically active compound according to claim 1 wherein R 1 is hydrogen, R 2 is n-butyl, R 3 is hydroxy, Y is ##STR29## X is ##STR30## Z is -CH 2 -CH═CH-(CH 2 ) 3 , and -C 13 -C 14 is trans-vinylene; l-9-oxo-11α,16-dihydroxy-16-vinyl-5-cis,13-trans-prostadienoic acid.
Claim 10
Dependent Claim
46 words
The racemic miture according to claim 1 wherein R 1 is hydrogen, R 2 is n-butyl, R 3 is hydroxy, Y is ##STR31## X is ##STR32## Z is -CH 2 -CH═CH-(CH 2 ) 3 -, and C 13 -C 14 - is trans-vinylene; dl-9-oxo-11α,16-dihydroxy-16-vinyl-5-cis, 13-trans-prostadienoic acid.
Claim 11
Dependent Claim
10 words
The optically active compound according to claim 1, l-9-oxo-11α,16-dihydroxy-16-cyclopropyl-20-ethyl-13-trans-prostadienoic acid.
Claim 12
Dependent Claim
9 words
The racemic mixture according to claim 1, dl-9-oxo-11α,16-dihydroxy-16-cyclopropyl-20-ethyl-13-trans-prostadienoic acid.
Claim 13
Dependent Claim
10 words
The optically active compound according to claim 1, l-9-oxo-11α,16-dihydroxy-16-cyclopropyl-5-cis,13-trans-prostadienoic acid.
Claim 14
Dependent Claim
9 words
The racemic mixture according to claim 1, dl-9-oxo-11α,16-dihydroxy-16-cyclopropyl-5-cis,13-trans-prostadieonic acid.
References Cited (Backward Citations)
US3965143A
Cited
JPS50131951A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-05 | 1981-06-06 | 1981-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-05 | 1985-06-06 | 1985-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-05 | 1989-06-06 | 1989-12-06 | $7700.00 | Window Closed / Lapsed |