Patent US4058595A successfully refreshed from Google Patents.
US4058595A
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Stabilized toothpastes containing an enzyme
Assignee: Colgate Palmolive Co
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Filing: 1974-03-21
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Granted: 1977-11-15
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Expires: 1994-03-21
Abstract
Abstract Toothpastes having cosmetic and enzymatic stability containing a neutral protease of B. subtilis, a partially hydrolyzed protein, and a Group IIA metal ion.
Inventors
- 👤 Daniel Colodney
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:30
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/30; A61K8/64; A61K8/65; A61K8/66; A61K2800/00; A61K2800/40; A61K2800/52
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
137 words
A toothpaste formulation consisting of essentially of about 0.2 to 10 percent by weight of a gelling agent and about 20 to 75 percent by weight of a liquid vehicle proportioned to form a creamy mass, about 0.5 to 5 percent by weight of a water-soluble organic detergent, about 20 to 75 percent by weight of a dentally acceptable polishing agent, at least about 0.05 percent by weight of the neutral protease of Bacillus subtilis, and a stabilizer for retention of protease activity consisting essentially of about 0.1 to 0.5 percent by weight of a protein having an average molecular weight ranging from about 10,000 up to about 300,000 selected from the group consisting of partially hydrolized edible proteins and edible proteins and about 0.1 to 1.0 percent by weight of a group IIA metal ion salt.
Claim 2
Dependent Claim
137 words
A toothpaste formulation consisting of essentially of about 0.2 to 10 percent by weight of a gelling agent and about 20 to 75 percent by weight of a liquid vehicle proportioned to form a creamy mass, about 0.5 to 5 percent by weight of a water-soluble organic detergent, about 20 to 75 percent by weight of a dentally acceptable polishing agent, at least about 0.05 percent by weight of the neutral protease of Bacillus subtilis, and a stabilizer for retention of protease activity consisting essentially of about 0.1 to 0.5 percent by weight of a protein having an average molecular weight ranging from about 10,000 up to about 300,000 selected from the group consisting of partially hydrolized edible proteins and edible proteins and about 0.1 to 1.0 percent by weight of a group IIA metal ion salt.
Claim 3
Dependent Claim
35 words
The toothpaste of claim 1 in which the neutral protease is present in an amount of about 0.25 percent by weight and the protein is present in an amount of about 0.5 percent by weight.
Claim 4
Dependent Claim
14 words
The toothpaste of claim 1 in which the Group IIA metal ion is magnesium.
Claim 5
Dependent Claim
25 words
The toothpaste of claim 1 wherein said polishing agent is selected from the group consisting of dicalcium phosphate dihydrate, dicalcium phosphate anhydrous and calcium carbonate.
Claim 6
Dependent Claim
24 words
The toothpaste of claim 1 in which the neutral protease has an activity of at least about 0.02 Anson units per gram of formulation.
Claim 7
Dependent Claim
26 words
The toothpaste of claim 1 in which the protein is selected from the group consisting of partially hydrolyzed gelatin, partially hydrolyzed casein, and partially hydrolyzed collagen.
Claim 8
Dependent Claim
19 words
The toothpaste of claim 1 in which the Group IIA metal ion is supplied as a water-soluble, nontoxic salt.
Claim 9
Dependent Claim
22 words
The toothpaste of claim 5 in which the neutral protease has an activity of about 0.04 Anson units per gram of formulation.
Claim 10
Dependent Claim
17 words
The toothpaste of claim 1 in which said water-soluble organic detergent is N-2 ethyl laurate potassium sulfoacetamide.
References Cited (Backward Citations)
US3325364A
Cited
US3696191A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-14 | 1981-05-16 | 1981-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-14 | 1985-05-16 | 1985-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-14 | 1989-05-16 | 1989-11-15 | $7700.00 | Window Closed / Lapsed |