Patent US4058594A successfully refreshed from Google Patents.
US4058594A
Expired / Lapsed
US
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Immuno-suppressive agents
Assignee: Individual
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Filing: 1976-08-10
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Granted: 1977-11-15
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Expires: 1996-08-10
Abstract
Abstract A method of providing an immuno-suppressive effect in the control or prophylaxis of neurological disorders, such as multiple sclerosis, and in organ and tissue transplants comprising administering a daily dosage of 5mg to 3g of γ-linolenic or dihomo-γ-linolenic acid or a functional derivative thereof, optionally together with a daily dosage of 25mg to 3g of linoleic acid or a functional derivative thereof. An oil extract from seeds of Oenothera biennis L. is a convenient source of γ-linolenic acid and linoleic acid.
Inventors
- 👤 John Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 09:06
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/22; A61K31/23; A61K31/185; A61K31/19; A61K31/20
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
62 words
A method of providing an immuno-suppressive effect in a patient suffering from multiple sclerosis which comprises administering to said patient a daily dosage of from 25mg to 3g of at least one compound selected from the group consisting of γ-linolenic acid, dihomo-γ-linolenic acid, C 1 -C 4 alkyl esters of γ-linolenic and dihomo-γ-linolenic acids and glyceride esters of γ-linolenic and dihomo-γ-linolenic acids.
Claim 2
Independent Claim
62 words
A method of providing an immuno-suppressive effect in a patient suffering from multiple sclerosis which comprises administering to said patient a daily dosage of from 25mg to 3g of at least one compound selected from the group consisting of γ-linolenic acid, dihomo-γ-linolenic acid, C 1 -C 4 alkyl esters of γ-linolenic and dihomo-γ-linolenic acids and glyceride esters of γ-linolenic and dihomo-γ-linolenic acids.
Claim 3
Dependent Claim
23 words
A method as claimed in claim 1 wherein a dose containing one third of the daily dosage is administered three times a day.
Claim 4
Dependent Claim
32 words
A method as claimed in claim 2 wherein the treatment is effected orally using capsules containing a unit dose of 250mg to 1g of an oil extract containing 5-20 wt.% γ-linolenic acid.
Claim 5
Dependent Claim
15 words
A method as claimed in claim 3 wherein the oil is microencapsulated within the capsules.
Claim 6
Dependent Claim
27 words
A method as claimed in claim 2 wherein the treatment is effected parenterally using a micronised emulsion containing 5-20% γ-linolenic acid in a unit dose of 10ml.
Claim 7
Independent Claim
85 words
A method of providing an immuno-suppressive effect in a patient suffering from multiple sclerosis which comprises administering to said patient a daily dosage of from 25mg to 3g of at least one compound selected from the group consisting of γ-linolenic acid, dihomo-γ-linolenic acid, C 1 -C 4 alkyl esters of γ-linolenic and dihomo-γ-linolenic acids and glyceride esters of γ-linolenic and dihomo-γ-linolenic acids, together with a daily dosage of from 5mg to 3g of linoleic acid, C 1 -C 4 alkyl esters or glyceride esters thereof.
Claim 8
Independent Claim
85 words
A method of providing an immuno-suppressive effect in a patient suffering from multiple sclerosis which comprises administering to said patient a daily dosage of from 25mg to 3g of at least one compound selected from the group consisting of γ-linolenic acid, dihomo-γ-linolenic acid, C 1 -C 4 alkyl esters of γ-linolenic and dihomo-γ-linolenic acids and glyceride esters of γ-linolenic and dihomo-γ-linolenic acids, together with a daily dosage of from 5mg to 3g of linoleic acid, C 1 -C 4 alkyl esters or glyceride esters thereof.
Claim 9
Dependent Claim
32 words
A method as claimed in claim 6 wherein an oil extract from the seeds of Oenothera biennis L. which contains both γ-linolenic acid or ester and linoleic acid or ester is administered.
Claim 10
Dependent Claim
25 words
A method as claimed in claim 7 wherein the oil extract is a fraction containing linoleic and γ-linolenic acids as the only fatty acid components.
References Cited (Backward Citations)
GB1082624A
Cited
GB1240513A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-14 | 1981-05-16 | 1981-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-14 | 1985-05-16 | 1985-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-14 | 1989-05-16 | 1989-11-15 | $7700.00 | Window Closed / Lapsed |