Patent US3137411A successfully refreshed from Google Patents.
Patent US4058557A successfully refreshed from Google Patents.
US4058557A
Expired / Lapsed
US
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Amidinoureas
Assignee: William H Rorer Inc
•
Filing: 1976-03-30
•
Granted: 1977-11-15
•
Expires: 1996-03-30
Abstract
Abstract A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
Inventors
- 👤 George Henry Douglas
- 👤 William Lyon Studt
- 👤 Stuart Alan Dodson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 06:11
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; A; A61; A61P; A61P1/00; A61P1/04; A61P1/12; A61P25/00; A61P25/08; C07D261/00; C07D261/02; C07D265/00; C07D265/04; C07D265/06
Claims Analysis
Total Claims: 62
Claim 1
Independent Claim
106 words
A compound of the formula: ##STR11## where: R 2 , R 3 , R 4 , R 5 and R 6 may be the same or different and are: hydrogen, halo, loweralkyl, haloloweralkyl, nitro, amino, acylamino, hydroxy, aralkyloxy or loweralkoxy; R n is nitrogen or loweralkyl; R 7 , r 8 , r 9 and R 10 may be the same or different and are: hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or aralkyl; px is 0-1; the sum total of carbon atoms present in R 7 , R 8 , R 9 and R 10 together is less than 12; and the non-toxic acid addition salts thereof.
Claim 2
Dependent Claim
106 words
A compound of the formula: ##STR11## where: R 2 , R 3 , R 4 , R 5 and R 6 may be the same or different and are: hydrogen, halo, loweralkyl, haloloweralkyl, nitro, amino, acylamino, hydroxy, aralkyloxy or loweralkoxy; R n is nitrogen or loweralkyl; R 7 , r 8 , r 9 and R 10 may be the same or different and are: hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or aralkyl; px is 0-1; the sum total of carbon atoms present in R 7 , R 8 , R 9 and R 10 together is less than 12; and the non-toxic acid addition salts thereof.
Claim 3
Dependent Claim
71 words
The compound of claim 1 where: R 2 and R 6 are halo, loweralkyl, haloloweralky, nitro or loweralkoxy; R 3 and R 5 are hydrogen; R 4 is hydrogen, halo, loweralkyl, amino, acylamino or hydroxy; R 7 , r 9 and R n are hydrogen or alkyl, R 7 and R 9 may also be aralkyl; R 8 and R 10 are hydrogen, loweralkyl, alkenyl or alkynyl; and x is 0-1.
Claim 4
Dependent Claim
64 words
The compound of claim 2 where: R 2 is halo or loweralkyl; R 3 , r 4 and R 5 are hydrogen; R 6 is loweralkyl, nitro, haloloweralkyl, loweralkoxy or halo; R 7 , r 9 and R n are hydrogen or alkyl; R 7 and R 9 may also be aralkyl; R 8 and R 10 are hydrogen or loweralkyl; x is 0-1.
Claim 5
Dependent Claim
78 words
The compound of claim 3 where: R 2 is chloro, bromo, fluoro, methyl or ethyl; R 3 , r 4 and R 5 are hydrogen; R 6 is methyl, ethyl, nitro, methoxy, ethoxy, chloro, bromo or fluoro; R n is hydrogen, methyl or ethyl, and R 8 and R 10 are hydrogen, methyl or ethyl; R 7 and R 9 are hydrogen, methy, ethyl, propyl, i-propyl, butyl, i-butyl, sec-butyl, t-butyl, pentyl, hexyl, heptyl or benzyl; x is 0.
Claim 6
Dependent Claim
57 words
The compound of claim 1 where: R 2 is chloro, bromo, fluoro, methyl or ethyl; R 3 , r 4 and R 5 are hydrogen, R 6 is methyl, ethyl, nitro, methoxy, ethoxy, chloro, bromo or fluoro; R n is hydrogen, methyl or ethyl, and R 9 and R 10 are hydrogen, methyl, ethyl x is 0.
Claim 7
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 8
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 9
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-(N-methoxy-N'-methylamidino)urea hydrochloride.
Claim 10
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-(N-methoxy-N'-methylamidino)urea hydrochloride.
Claim 11
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-benzyloxyamidinourea hydrochloride.
Claim 12
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-benzyloxyamidinourea hydrochloride.
Claim 13
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-hydroxyamidinourea hydrochloride.
Claim 14
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-hydroxyamidinourea hydrochloride.
Claim 15
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 16
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 17
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-methoxyamidinourea succinate.
Claim 18
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-methoxyamidinourea succinate.
Claim 19
Dependent Claim
2 words
1-(2-bromo-6-methylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 20
Dependent Claim
2 words
1-(2-bromo-6-methylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 21
Dependent Claim
2 words
1-(2-chloro-6-methylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 22
Dependent Claim
2 words
1-(2-chloro-6-methylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 23
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-ethoxyamidinourea hydrochloride.
Claim 24
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-ethoxyamidinourea hydrochloride.
Claim 25
Dependent Claim
2 words
1-(2-chloro-6-methyl)-3-ethoxyamidinourea hydrochloride.
Claim 26
Dependent Claim
2 words
1-(2-chloro-6-methyl)-3-ethoxyamidinourea hydrochloride.
Claim 27
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-n-butoxyamidinourea hydrochloride.
Claim 28
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-n-butoxyamidinourea hydrochloride.
Claim 29
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-n-propoxyamidinourea hydrochloride.
Claim 30
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-n-propoxyamidinourea hydrochloride.
Claim 31
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-(N-methoxy-N'-methylamidino)urea hydrochloride.
Claim 32
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-(N-methoxy-N'-methylamidino)urea hydrochloride.
Claim 33
Dependent Claim
2 words
1-(2-chloro-6-methylphenyl)-3-(N-methoxy-N'-methylamidino)urea hydrochloride.
Claim 34
Dependent Claim
2 words
1-(2-chloro-6-methylphenyl)-3-(N-methoxy-N'-methylamidino)urea hydrochloride.
Claim 35
Dependent Claim
2 words
1-(4-bromo-2,6-diethylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 36
Dependent Claim
2 words
1-(4-bromo-2,6-diethylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 37
Dependent Claim
2 words
1-(4-bromo-2-chloro-6-methylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 38
Dependent Claim
2 words
1-(4-bromo-2-chloro-6-methylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 39
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-ethoxyamidinourea succinate.
Claim 40
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-ethoxyamidinourea succinate.
Claim 41
Dependent Claim
2 words
1-(4-bromo-2,6-dimethylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 42
Dependent Claim
2 words
1-(4-bromo-2,6-dimethylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 43
Dependent Claim
2 words
1-(2,6-diethyl-4-nitrophenyl)-3-methoxyamidinourea hydrochloride.
Claim 44
Dependent Claim
2 words
1-(2,6-diethyl-4-nitrophenyl)-3-methoxyamidinourea hydrochloride.
Claim 45
Dependent Claim
2 words
1-(2-chloro-6-methylphenyl)-3-n-butoxyamidinourea hydrochloride.
Claim 46
Dependent Claim
2 words
1-(2-chloro-6-methylphenyl)-3-n-butoxyamidinourea hydrochloride.
Claim 47
Dependent Claim
2 words
1-(1-naphthyl)-3-methoxyamidinourea hydrochloride.
Claim 48
Dependent Claim
2 words
1-(1-naphthyl)-3-methoxyamidinourea hydrochloride.
Claim 49
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-n-propoxyamidinourea succinate.
Claim 50
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-n-propoxyamidinourea succinate.
Claim 51
Dependent Claim
2 words
1-(2,6-dibromo-4-ethylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 52
Dependent Claim
2 words
1-(2,6-dibromo-4-ethylphenyl)-3-methoxyamidinourea hydrochloride.
Claim 53
Dependent Claim
2 words
1-(4-amino-2,6-diethylphenyl)-3-methoxyamidinourea dihydrochloride.
Claim 54
Dependent Claim
2 words
1-(4-amino-2,6-diethylphenyl)-3-methoxyamidinourea dihydrochloride.
Claim 55
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-hydroxyamidinourea hydrochloride.
Claim 56
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-hydroxyamidinourea hydrochloride.
Claim 57
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-benzyloxyamidinourea hydrochloride.
Claim 58
Dependent Claim
2 words
1-(2,6-dimethylphenyl)-3-benzyloxyamidinourea hydrochloride.
Claim 59
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-n-butoxyamidinourea succinate.
Claim 60
Dependent Claim
2 words
1-(2,6-diethylphenyl)-3-n-butoxyamidinourea succinate.
Claim 61
Dependent Claim
2 words
1-(2-chloro-6-methylphenyl)-3-n-propoxyamidinourea hydrochloride.
Claim 62
Dependent Claim
2 words
1-(2-chloro-6-methylphenyl)-3-n-propoxyamidinourea hydrochloride.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-14 | 1981-05-16 | 1981-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-14 | 1985-05-16 | 1985-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-14 | 1989-05-16 | 1989-11-15 | $7700.00 | Window Closed / Lapsed |