Patent US1608077A successfully refreshed from Google Patents.
Patent US4058519A successfully refreshed from Google Patents.
US4058519A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Adriamycins and uses thereof
Assignee: Pfizer Italia SRL
•
Filing: 1975-03-19
•
Granted: 1977-11-15
•
Expires: 1995-03-19
Abstract
Abstract The known antitumor antibiotic adriamycin and its beta -anomer, and the novel compounds, 4'-epiadriamycin (both alpha - and beta -anomers) are prepared by condensing a novel, reactive protected derivative of adriamycinone with reactive intermediates which are 1-halo-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy- alpha -L-lyxo (or arabino) hexopyranoses.
Inventors
- 👤 Federico Arcamone
- 👤 Aurelio Di Marco
- 👤 Sergio Penco
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 10:42
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252; A; A61; A61P; A61P35/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
16 words
A compound selected from the group consisting of 4'-epi-adriamycin (α-anomer), 4'-epiadriamycin (β-anomer) and a mixture thereof.
Claim 2
Dependent Claim
16 words
A compound selected from the group consisting of 4'-epi-adriamycin (α-anomer), 4'-epiadriamycin (β-anomer) and a mixture thereof.
Claim 3
Dependent Claim
10 words
A compound according to claim 1, which is 4'-epiadriamycyn (α-anomer).
Claim 4
Dependent Claim
10 words
A compound according to claim 1, which is 4'-epiadriamycin (β-anomer).
Claim 5
Dependent Claim
33 words
A compound according to claim 1, which is a mixture of the α- and β-anomers of 4'-epiadriamycin wherein the α-anomer comprises about 70% by weight and the β-anomer comprises about 40% by weight.
Claim 6
Independent Claim
67 words
A method of inhibiting the growth of a tumor selected from the group consisting of Moloney Sarcoma Virus, Sarcoma 180 Ascites, Solid Sacroma 180, gross transplantable leukemia and L.sub. 1210 leukemia which comprises administering to a host afflicted with said tumor an amount of a compound selected from the group consisting of 4'-epiadriamycin, α-anomer, 4'-epiadriamycin, β-anomer and mixtures thereof sufficient to inhibit the growth of said tumor.
Claim 7
Independent Claim
67 words
A method of inhibiting the growth of a tumor selected from the group consisting of Moloney Sarcoma Virus, Sarcoma 180 Ascites, Solid Sacroma 180, gross transplantable leukemia and L.sub. 1210 leukemia which comprises administering to a host afflicted with said tumor an amount of a compound selected from the group consisting of 4'-epiadriamycin, α-anomer, 4'-epiadriamycin, β-anomer and mixtures thereof sufficient to inhibit the growth of said tumor.
Claim 8
Dependent Claim
12 words
A method according to claim 5, wherein the compound is administered intravenously.
Claim 9
Dependent Claim
12 words
A method according to claim 5, wherein the compound is administered intraperitoneally.
References Cited (Backward Citations)
US3356674A
Cited
US3427300A
Cited
US3590028A
Cited
US3803124A
Cited
US3629231A
Cited
US3651090A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-14 | 1981-05-16 | 1981-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-14 | 1985-05-16 | 1985-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-14 | 1989-05-16 | 1989-11-15 | $7700.00 | Window Closed / Lapsed |