Patent US4057618A successfully refreshed from Google Patents.
US4057618A
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Radioiodinated bleomycin
Assignee: University Patents Inc
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Filing: 1976-04-30
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Granted: 1977-11-08
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Expires: 1996-04-30
Abstract
Abstract Radioiodinated bleomycin is a useful imaging agent for body tissues. Its production by reaction of bleomycin with N-hydroxysuccinimide esters of radioiodinated hydroxyphenylalkanoic acid is described.
Inventors
- 👤 Sydney E. Salmon
- 👤 Rosa H. Liu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 16:44
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K2123/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
22 words
Radioiodinated hydroxyphenylacyl bleomycin, wherein the radioiodine is selected from the group consisting of I 123 , I 125 and I 131 .
Claim 2
Dependent Claim
22 words
Radioiodinated hydroxyphenylacyl bleomycin, wherein the radioiodine is selected from the group consisting of I 123 , I 125 and I 131 .
Claim 3
Dependent Claim
25 words
Radioiodinated hydroxyphenylacyl bleomycin as defined by claim 1, wherein the radioiodinated bleomycin contains about 0.1 to about 5 millicuries of radioiodine per milligram of bleomycin.
Claim 4
Dependent Claim
36 words
Method for producing radioiodinated bleomycin which comprises reacting bleomycin in aqueous solution with radioiodinated hydroxyphenylacyl N-hydroxysuccinimide then separating the radioiodinated hydroxyphenylacyl bleomycin from the excess of radioiodide ion to produce an aqueous solution of radioiodinated bleomycin.
Claim 5
Dependent Claim
36 words
Method for producing radioiodinated bleomycin which comprises reacting bleomycin in aqueous solution with radioiodinated hydroxyphenylacyl N-hydroxysuccinimide then separating the radioiodinated hydroxyphenylacyl bleomycin from the excess of radioiodide ion to produce an aqueous solution of radioiodinated bleomycin.
Claim 6
Dependent Claim
27 words
Method of claim 3 wherein the radioiodide ion is selected from the group consisting of 123 I - , 125 I - and 131 I - .
Claim 7
Dependent Claim
19 words
Method of claim 4 wherein the aqueous solution of bleomycin is maintained at a pH of 6.5 to 8.5.
Claim 8
Dependent Claim
10 words
Method of claim 5 wherein the hydroxyphenylacyl radical is p-hydroxyphenylpropionyl.
Claim 9
Dependent Claim
19 words
Method of claim 5 wherein the excess of radioiodide ion is removed by ion exchange or gel permeation chromatography.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-07 | 1981-05-09 | 1981-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-07 | 1985-05-09 | 1985-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-07 | 1989-05-09 | 1989-11-08 | $7700.00 | Window Closed / Lapsed |