US4056519A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substrate for assay of plasmin
Assignee: Eli Lilly and Co
•
Filing: 1976-05-10
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Granted: 1977-11-01
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Expires: 1996-05-10
Abstract
Abstract The proteinase plasmin is assayed either colorimetrically or fluorometrically with a tripeptidyl-4-methoxy-2-naphthylamide substrate having the following general formula: ##STR1## The substrate is useful for either routine clinical assays or kinetic studies.
Inventors
- 👤 Jesse L. Bobbitt
- 👤 Edward L. Smithwick, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:06
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0802; C07K5/0804; C07K5/0812; Y; Y10; Y10S; Y10S530/00; Y10S530/802
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
61 words
A tripeptidyl-4-methoxy-2-naphthylamide having the formula, ##STR3## in which R 1 and R 2 independently are hydrogen, alkyl, hydroxyalkyl, mercaptoalkyl, methylthioalkyl, benzyl, or hydroxybenzyl, with the proviso that at least one of R 1 and R 2 must be other than benzyl or hydroxybenzyl; and the acid addition salts thereof in which the acid is inorganic or C 1 -C 2 carboxylic.
Claim 2
Dependent Claim
61 words
A tripeptidyl-4-methoxy-2-naphthylamide having the formula, ##STR3## in which R 1 and R 2 independently are hydrogen, alkyl, hydroxyalkyl, mercaptoalkyl, methylthioalkyl, benzyl, or hydroxybenzyl, with the proviso that at least one of R 1 and R 2 must be other than benzyl or hydroxybenzyl; and the acid addition salts thereof in which the acid is inorganic or C 1 -C 2 carboxylic.
Claim 3
Dependent Claim
17 words
The compound of claim 1 in which R 1 and R 2 independently are hydrogen or alkyl.
Claim 4
Dependent Claim
18 words
The compound of claim 1, in which R 1 and R 2 are the same and are alkyl.
Claim 5
Dependent Claim
14 words
The compound of claim 2, in which R 1 and R 2 are hydrogen.
Claim 6
Dependent Claim
14 words
The compound of claim 3, in which R 1 and R 2 are methyl.
References Cited (Backward Citations)
US3862011A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-31 | 1981-05-02 | 1981-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-31 | 1985-05-02 | 1985-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-31 | 1989-05-02 | 1989-11-01 | $7700.00 | Window Closed / Lapsed |