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US4053606A
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Mercaptoalkylpyridine disulfides
Assignee: Merck and Co Inc
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Filing: 1976-07-16
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Granted: 1977-10-11
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Expires: 1996-07-16
Abstract
Abstract Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.
Inventors
- 👤 Tsung-Ying Shen
- 👤 Howard Jones
- 👤 Conrad P. Dorn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 16:47
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/28; C07D213/30; C07D213/26; C07D213/32; C07D213/34; C07D213/44; C07D213/46; C07D213/48; C07D213/51; C07D213/60; C07D213/62; C07D213/63; C07D213/65; C07D213/66; C07D213/78; C07D213/79; C07D213/80; C07D213/89; C07D263/00; C07D263/02; C07D263/30; C07D263/34; C07D263/36; C07D263/42; C07D491/00; C07D491/02; C07D491/04; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/553; C07F9/576; C07F9/58
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
73 words
A compound of structural formula: ##STR3## or pharmaceutically acceptable salt thereof wherein m is 0 or 1; R" is H or C 2-6 alkanoyl; A is ##STR4## or -C═C, where R 7 is hydrogen, chloro or fluoro; R is C 1-3 alkyl, hydroxy, C 2-6 alkanoyloxy or hydroxy-C 1-3 alkyl; R 1 and R 2 are hydrogen or C 1-3 alkyl; and R 4 is hydrogen, C 1-3 alkyl, phenyl, chloro or fluoro
Claim 2
Dependent Claim
73 words
A compound of structural formula: ##STR3## or pharmaceutically acceptable salt thereof wherein m is 0 or 1; R" is H or C 2-6 alkanoyl; A is ##STR4## or -C═C, where R 7 is hydrogen, chloro or fluoro; R is C 1-3 alkyl, hydroxy, C 2-6 alkanoyloxy or hydroxy-C 1-3 alkyl; R 1 and R 2 are hydrogen or C 1-3 alkyl; and R 4 is hydrogen, C 1-3 alkyl, phenyl, chloro or fluoro
Claim 3
Dependent Claim
17 words
The compound of claim 1 of structural formula: ##STR5## wherein R" is H or C 2-6 alkanoyl.
Claim 4
Dependent Claim
19 words
The compound of formula: ##STR6## or pharmaceutically acceptable salt thereof, wherein R 11 is hydrogen or C 2-6 alkanoyl.
Claim 5
Dependent Claim
19 words
The compound of formula: ##STR6## or pharmaceutically acceptable salt thereof, wherein R 11 is hydrogen or C 2-6 alkanoyl.
Claim 6
Dependent Claim
9 words
The compound of claim 3 which is bis[2-methyl-3-hydroxy-5-vinylpyrid-4-ylmethyl]disulfide sulfate.
Claim 7
Dependent Claim
24 words
An anti-inflammatory composition in unit dosage form comprising an inert carrier and 5 mg. to 5 gm. of a compound of structural formula: ##STR7##
Claim 8
Dependent Claim
24 words
An anti-inflammatory composition in unit dosage form comprising an inert carrier and 5 mg. to 5 gm. of a compound of structural formula: ##STR7##
Claim 9
Dependent Claim
25 words
The anti-inflammatory composition of claim 5 wherein the active ingredient is a compound of structural formula: ##STR8## wherein R" is H or C 2-6 alkanoyl.
Claim 10
Dependent Claim
27 words
The anti-inflammatory composition of claim 6 wherein the compound is of formula: ##STR9## or pharmaceutically acceptable salt thereof, wherein R 11 is hydrogen or C 2-6 alkanoyl.
Claim 11
Dependent Claim
12 words
The anti-inflammatory composition of claim 7 wherein the compound is bis[2-methyl-3-hydroxy-5-vinylpyrid-4-ylmethyl]disulfide sulfate.
Claim 12
Independent Claim
31 words
A method of treating rheumatoid arthritis which comprises the administration, to a warm-blooded animal or human in need of such treatment, an effective amount of a compound of structural formula: ##STR10##
Claim 13
Independent Claim
31 words
A method of treating rheumatoid arthritis which comprises the administration, to a warm-blooded animal or human in need of such treatment, an effective amount of a compound of structural formula: ##STR10##
Claim 14
Dependent Claim
21 words
The method of claim 9 wherein the compound is of structural formula: ##STR11## wherein R" is H or C 2-6 alkanoyl.
Claim 15
Dependent Claim
24 words
The method of claim 10, wherein the compound is: ##STR12## or pharmaceutically acceptable salt thereof, wherein R 11 is hydrogen or C 2-6 alkanoyl.
Claim 16
Dependent Claim
11 words
The method of claim 11 wherein the compound is bis[2-methyl-3-hydroxy-5-vinylpyrid-4-ylmethyl]-disulfide sulfate.
References Cited (Backward Citations)
US3530138A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-10 | 1981-04-11 | 1981-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-10 | 1985-04-11 | 1985-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-10 | 1989-04-11 | 1989-10-11 | $7700.00 | Window Closed / Lapsed |