US4051248A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1,3,8-triazaspiro(4.5)decan-4-one derivatives
Assignee: ER Squibb and Sons LLC
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Filing: 1976-05-20
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Granted: 1977-09-27
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Expires: 1996-05-20
Abstract
Abstract Compounds having the structure ##STR1## and the pharmaceutically acceptable salts thereof, wherein R 1 is hydrogen, halogen, hydroxy, alkanoyloxy, alkoxy, alkylthio, alkyl or trifluoromethyl; R 2 is hydrogen, alkyl or alkenyl; R 3 is hydrogen, halogen or alkyl; R 4 is formyloxy or alkanoyloxy; m is 1 or 2; and n is 0, 1 or 2; have useful physiological activity.
Inventors
- 👤 B. Richard Vogt
- 👤 David A. Cullison
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 07:23
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/68; C07D211/72; C07D211/74; A; A61; A61P; A61P25/00; A61P25/20; C07C; C07C17/00; C07C17/26; C07C17/32; C07D211/06; C07D211/36; C07D211/60; C07D211/62; C07D211/66
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
92 words
A compound having the formula ##STR19## or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, halogen, hydroxy, alkanoyloxy, alkoxy, alkylthia, alkyl or trifluoromethyl; R 2 is hydrogen, alkyl or alkenyl having 2 to 4 carbon atoms; R 3 is hydrogen, halogen or alkyl; R 4 is formyloxy or alkanoyloxy; m is 1 or 2; and n is 0, 1 or 2; wherein the terms alkyl, alkoxy and alkylthio refer to groups having 1 to 10 carbon atoms and the term alkanoyloxy refers to groups having 2 to 11 carbon atoms.
Claim 2
Dependent Claim
92 words
A compound having the formula ##STR19## or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, halogen, hydroxy, alkanoyloxy, alkoxy, alkylthia, alkyl or trifluoromethyl; R 2 is hydrogen, alkyl or alkenyl having 2 to 4 carbon atoms; R 3 is hydrogen, halogen or alkyl; R 4 is formyloxy or alkanoyloxy; m is 1 or 2; and n is 0, 1 or 2; wherein the terms alkyl, alkoxy and alkylthio refer to groups having 1 to 10 carbon atoms and the term alkanoyloxy refers to groups having 2 to 11 carbon atoms.
Claim 3
Dependent Claim
11 words
A compound in accordance with claim 1 having the formula ##STR20##
Claim 4
Dependent Claim
11 words
A compound in accordance with claim 1 having the formula ##STR21##
Claim 5
Dependent Claim
11 words
A compound in accordance with claim 1 having the formula ##STR22##
Claim 6
Dependent Claim
11 words
A compound in accordance with claim 1 having the formula ##STR23##
Claim 7
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 0.
Claim 8
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 1.
Claim 9
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 2.
Claim 10
Dependent Claim
11 words
A compound in accordance with claim 1 wherein m is 1.
Claim 11
Dependent Claim
18 words
A compound in accordance with claim 1 wherein m is 2 and R 1 is alkyl or alkoxy.
Claim 12
Dependent Claim
15 words
A compound in accordance with claim 1 wherein R 2 and R 3 are hydrogen.
Claim 13
Dependent Claim
15 words
A compound in accordance with claim 1 wherein R 1 is hydrogen, alkyl or halogen.
Claim 14
Dependent Claim
17 words
The compound in accordance with claim 1 having the name 8-[(7-chloro-3,4-dihydro-2-naphthalenyl]-1-phenyl-1,3,8,-triazaspiro[4.5]decan-4-one or a pharmaceutically acceptable salt thereof.
Claim 15
Dependent Claim
17 words
The compound in accordance with claim 1 having the name 8-[(3,4-dihydro-2-naphthalenyl)methyl]-1-1,3,8-triazaspiro[4.5]decan-4-one or a pharmaceutically acceptable salt thereof.
Claim 16
Dependent Claim
21 words
A neuroleptic composition comprising a therapeutic amount of a compound as defined in claim 1 and a pharmaceutically acceptable carrier thereof.
Claim 17
Dependent Claim
27 words
A method of treating psychic disorders in mammalian species which comprises administering to a mammalian host a therapeutic amount of a compound as defined in claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-09-26 | 1981-03-28 | 1981-09-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-09-26 | 1985-03-28 | 1985-09-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-09-26 | 1989-03-28 | 1989-09-27 | $7700.00 | Window Closed / Lapsed |