US4051141A
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Thieno[3,2-c]pyridine derivatives
Assignee: Sanofi SA
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Filing: 1976-02-20
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Granted: 1977-09-27
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Expires: 1996-02-20
Abstract
Abstract Thieno[3,2-c]pyridine derivatives having the formula: ##STR1## in which X is S; R is a phenyl or benzoyl radical optionally substituted with 1-3 halogen atoms or lower alkyl, lower alkoxy, hydroxy or nitro; R 1 is hydrogen, halogen, hydroxy or lower alkyl; R 2 is hydrogen or halogen and n is 1 or 2, and in which the symbols R 1 may be different in each CHR 1 when n is 2; and their pharmaceutically acceptable acid addition salts. Said derivatives are therapeutically useful for their anti-inflammatory, vasodilatator and blood plate aggregation inhibitor action.
Inventors
- 👤 Albert Rene Joseph Castaigne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 23:03
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/02; C07D491/04; C07D491/044; C07D491/048; A; A61; A61P; A61P29/00; A61P7/00; A61P7/02; A61P9/00; A61P9/08; C07D495/00; C07D495/02; C07D495/04
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
137 words
A compound selected from the derivatives of the formula: ##STR6## in which X is sulfur; R is selected from the group consisting of phenyl, phenyl substituted with 1 or 2 halogen atoms or alkyl having 1-6 carbon atoms or alkoxy having 1-6 carbon atoms or hydroxy or nitro, benzoyl, and benzoyl substituted with chloro or fluoro or alkyl having 1-6 carbon atoms or alkoxy having 1-6 carbon atoms or 1 or 2 hydroxy groups or nitro; R 1 is selected from the group consisting of hydrogen, halogen, hydroxy and alkyl having 1-6 carbon atoms; R 2 is selected from hydrogen and halogen and n is 1 or 2, and in which the symbols R 1 may have different meanings in each radical --(CHR 1 )-- when n is 2; and the pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
137 words
A compound selected from the derivatives of the formula: ##STR6## in which X is sulfur; R is selected from the group consisting of phenyl, phenyl substituted with 1 or 2 halogen atoms or alkyl having 1-6 carbon atoms or alkoxy having 1-6 carbon atoms or hydroxy or nitro, benzoyl, and benzoyl substituted with chloro or fluoro or alkyl having 1-6 carbon atoms or alkoxy having 1-6 carbon atoms or 1 or 2 hydroxy groups or nitro; R 1 is selected from the group consisting of hydrogen, halogen, hydroxy and alkyl having 1-6 carbon atoms; R 2 is selected from hydrogen and halogen and n is 1 or 2, and in which the symbols R 1 may have different meanings in each radical --(CHR 1 )-- when n is 2; and the pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
12 words
A compound selected from 5-(2-chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.
Claim 4
Dependent Claim
12 words
A compound selected from 5-(2-chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.
Claim 5
Dependent Claim
12 words
A compound selected from 5-(4-methoxybenzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.
Claim 6
Dependent Claim
12 words
A compound selected from 5-(4-methoxybenzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.
Claim 7
Dependent Claim
12 words
A compound selected from 5-(3,4,5-trimethoxybenzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.
Claim 8
Dependent Claim
12 words
A compound selected from 5-(3,4,5-trimethoxybenzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.
Claim 9
Dependent Claim
12 words
A compound selected from 5-parachlorobenzyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.
Claim 10
Dependent Claim
12 words
A compound selected from 5-parachlorobenzyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.
Claim 11
Dependent Claim
12 words
A compound selected from 5-(2-fluoro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.
Claim 12
Dependent Claim
12 words
A compound selected from 5-(2-fluoro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-09-26 | 1981-03-28 | 1981-09-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-09-26 | 1985-03-28 | 1985-09-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-09-26 | 1989-03-28 | 1989-09-27 | $7700.00 | Window Closed / Lapsed |