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US4049692A Expired / Lapsed US ⏱️ 0.0 years remaining

Stabilized blood separating composition

Assignee: Corning Glass Works
•
Filing: 1974-12-16
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Granted: 1977-09-20
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Expires: 1994-12-16
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Abstract

Abstract Gel-like composition useful for separating and partitioning whole blood into serum and clot portions. The composition has a specific gravity between that of the serum and clot portions such that, when centrifuged in the presence of whole blood, the composition forms a chemical and physical barrier between the serum and clot portions. The composition comprises, in combination, a silicone fluid, an inert siliceous filler dispersed therein, and a network former consisting of a polysiloxane-polyoxyalkyl copolymer which stabilizes the composition by minimizing and/or avoiding "wet out" of the siliceous filler with time. The composition has a viscosity within the range of about 200,000 to about 600,000 centistokes, preferably within the range of about 350,000 to about 450,000 centistokes.

Inventors

  • 👤 Anthony R. Zine, Jr.

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 20:45
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491; C; C08; C08K; C08K3/00; C08K3/34; C08K3/36; C08L; C08L83/00; C08L83/04; C08L83/10; C08L83/12; C08G; C08G77/00; C08G77/04; C08G77/14; C08G77/42; C08G77/46; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/107497

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 170 words
In a thixotropic composition useful as a chemical and physical barrier between serum and clot portions of separated blood, the composition comprising a gel-like material having a specific gravity within the range of about 1.030 to 1.090 and consisting of a dimethylsiloxane silicone fluid having an inert siliceous filler dispersed therein, the improvement which comprises the addition of a network former in a quantity sufficient to maintain the viscosity of the composition within the range of 200,000 to 600,000 centistokes for prolonged periods of time, the network former consisting of a polysiloxane-polyoxyalkyl copolymer represented by the following formual ##STR2## where the monomeric units are randomly distributed and Me represents --CH 3 ; x represents a number between 80 and 120; y represents a number between 8 and 12; P represents a polyoxyalkyl side chain represented by the formula CH.sub.2 --CH.sub.2 --O).sub.m (CH.sub.2 --CH.sub.2 --CH.sub.2 --O).sub.n where the monomeric units are randomly distributed and m represents a number between 20 and 30; and n represents a number between 1 and 30.
Claim 2
Dependent Claim 170 words
In a thixotropic composition useful as a chemical and physical barrier between serum and clot portions of separated blood, the composition comprising a gel-like material having a specific gravity within the range of about 1.030 to 1.090 and consisting of a dimethylsiloxane silicone fluid having an inert siliceous filler dispersed therein, the improvement which comprises the addition of a network former in a quantity sufficient to maintain the viscosity of the composition within the range of 200,000 to 600,000 centistokes for prolonged periods of time, the network former consisting of a polysiloxane-polyoxyalkyl copolymer represented by the following formual ##STR2## where the monomeric units are randomly distributed and Me represents --CH 3 ; x represents a number between 80 and 120; y represents a number between 8 and 12; P represents a polyoxyalkyl side chain represented by the formula CH.sub.2 --CH.sub.2 --O).sub.m (CH.sub.2 --CH.sub.2 --CH.sub.2 --O).sub.n where the monomeric units are randomly distributed and m represents a number between 20 and 30; and n represents a number between 1 and 30.
Claim 3
Dependent Claim 23 words
The composition, as claimed in claim 1, wherein the specific gravity of the composition is within the range of about 1.037 and 1.050.
Claim 4
Dependent Claim 24 words
The composition, as claimed in claim 2, wherein the viscosity of the composition is within the range of about 350,000 to about 450,000 centistokes.
Claim 5
Dependent Claim 26 words
The composition, as claimed in claim 1, wherein the filler consists of silica particles having a surface area of at least about 80 m 2 /g.

References Cited (Backward Citations)

US3780935A Cited
US4018564A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-09-19 1981-03-21 1981-09-20 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-09-19 1985-03-21 1985-09-20 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-09-19 1989-03-21 1989-09-20 $7700.00 Window Closed / Lapsed

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