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US4048416A
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US
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Thiopolymers, their derivatives and methods for their preparation and use
Assignee: Exploaterings TBF AB
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Filing: 1975-05-27
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Granted: 1977-09-13
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Expires: 1995-05-27
Abstract
Abstract A method for producing products for separation, ion exchange or as basic material for the preparation of various derivatives designed for separation purposes and adsorption purposes by means of a polymer being activated with a reagent containing at least two bifunctional groups so that at least one of the reactive, functional groups in each molecule is bonded to the polymer while leaving a considerable amount of remaining groups unreacted but still reactive so that the activated polymer can be caused to react with thiosulphate after surplus reagent has been eliminated. The invention also relates to the produced products or their derivatives consisting of a water-soluble hydroxyl group or amino group containing polymer substituted with organic side-chains, each containing one or more thiosulphate groups or derivatives of such groups and the use of the products for purification of water, separation, immobilization of enzymes, etc.
Inventors
- 👤 Rolf Erik Axel Verner Axen
- 👤 Jerker Olof Porath
- 👤 Per Jan Erik Carlsson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 17:59
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/22; B01J20/26; B01J20/265; C; C08; C08B; C08B11/00; C08B11/02; C08B11/04; C08B11/10; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0021; C08B37/0036; C08B37/0039; C12; C12N; C12N11/00; C12N11/02; Y; Y10; Y10S; Y10S435/00; Y10S435/814; Y10S435/816; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/813; Y10S530/814; Y10S530/815; Y10S530/816
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
84 words
A product designed for separation purposes, for ion exchange purposes or as basic material for the preparation of various derivatives designed for separation purposes, for the purpose of adsorbing or immobilizing various compounds of in particular biochemical interest, as well as products consisting of derivatives of such product, characterized in that they consist of a water-insoluble hydroxyl or amino group containing polymer substituted with organic side-chains each containing one or more thiosulphate groups (--S 2 O 3 - groups) or derivatives of such groups.
Claim 2
Dependent Claim
84 words
A product designed for separation purposes, for ion exchange purposes or as basic material for the preparation of various derivatives designed for separation purposes, for the purpose of adsorbing or immobilizing various compounds of in particular biochemical interest, as well as products consisting of derivatives of such product, characterized in that they consist of a water-insoluble hydroxyl or amino group containing polymer substituted with organic side-chains each containing one or more thiosulphate groups (--S 2 O 3 - groups) or derivatives of such groups.
Claim 3
Dependent Claim
15 words
A product as claimed in claim 1, characterized in that the polymer is a gel.
Claim 4
Dependent Claim
18 words
A product as claimed in claim 1, characterized in that the polymer is agar or an agar derivative.
Claim 5
Dependent Claim
101 words
A product as claimed in claim 1, characterized in that the substituting organic side chains have the general formula ##STR17## where R is CH 2 , CH 2 --CH 2 --SO 2 or CH 2 --CH(OH)--CH 2 --O--R 2 --O--CH 2 R 2 being a straight chain or branched alkylene group, Z is H and/or alkyl, R' is H, alkyl, alkenyl or aryl and X is OH, H or S 2 O 3 - when Y is S 2 O 3 - or X is S 2 O 3 - when Y is OH, H or S 2 O 3 .
Claim 6
Dependent Claim
16 words
A product as claimed in claim 1, characterized by the general formula polymer--O--CH.sub.2 --CH(OH)--CH.sub.2 --S.sub.2 O.sub.3.sup.-.
Claim 7
Dependent Claim
19 words
A product as claimed in claim 1, characterized by the general formula polymer--O--CH.sub.2 --CH(OH)--CH.sub.2 --O--(CH.sub.2).sub.4 --CH.sub.2 --CH(OH)--CH.sub.2 --S.sub.2 O.sub.3.sup.-.
Claim 8
Dependent Claim
19 words
A product as claimed in claim 1, characterized by the general formula polymer--O--CH.sub.2 --CH.sub.2 --SO.sub.2 --CH.sub.2 --CH.sub.2 --S.sub.2 O.sub.3.sup.-.
Claim 9
Dependent Claim
17 words
A product as claimed in claim 1, characterized by the general formula polymer--O--CH.sub.2 --CH(S.sub.2 O.sub.3.sup.-)--CH.sub.2 --(S.sub.2 O.sub.3.sup.-).
Claim 10
Dependent Claim
34 words
A product as claimed in claim 1, characterized in that said S 2 O 3 - groups, either all of them or a fraction thereof, have been converted into or replaced by --SH groups.
Claim 11
Dependent Claim
27 words
A product as claimed in claim 9, characterized in that the --SH groups, all of them or a fraction thereof, have been converted into --S--S-- (disulphide) groups.
Claim 12
Dependent Claim
30 words
A product as claimed in claim 8, characterized in that the thiosulphate groups, either all of them or a fraction thereof, have been converted into or replaced by --SH groups.
Claim 13
Dependent Claim
80 words
A method for the preparation of products as claimed in claim 1 wherein the polymer is first activated by a reagent containing at least two bi-functional groups in a manner such that at least one of the reactive functional groups in each molecule is bonded to the polymer leaving a sizeable number of the remaining groups in an unreacted but reactive form whereupon, after elimination of excess reagent, the thereby activated polymer is led to react with a thiosulphate solution.
Claim 14
Dependent Claim
36 words
A method for the preparation of a product as claimed in claim 5, wherein the activation reagent consists of an epihalohydrin in alkaline solution or of a substance which in alkaline solution gives rise to dibromopropanol.
Claim 15
Dependent Claim
37 words
A method for the preparation of a product as claimed in claim 6, wherein the activating reagent consists of a bis-epoxide in alkaline solution or of a substance which in alkaline solution gives rise to a bis-expoxide.
Claim 16
Dependent Claim
27 words
A method for the preparation of a product as claimed in claim 7, wherein the activating reagent consists of divinylsulphone, or a derivative thereof, in alkaline solution.
Claim 17
Dependent Claim
44 words
A method for the preparation of a product as claimed in claim 8, wherein the polymer is first reacted with allyl bromide followed by the addition of bromine to the produced allyl polymer, whereupon the resulting product is reacted with a thiosulphate in solution.
Claim 18
Dependent Claim
44 words
A method for the transformation of products as claimed in claim 9 into thiol-polymers, wherein the conversion product from a thiosulphate-polymer is reacted with a solution of a compound which has the capacity to transform the --S 2 O 3 groups into --SH groups.
Claim 19
Dependent Claim
25 words
A method as claimed in claim 17, wherein the transformation of thiosulphate into thiol occurs through reaction with a solution of 1,4-dimercaptobutane or derivatives thereof.
Claim 20
Dependent Claim
18 words
A method as claimed in claim 18, wherein the reducing agent is a solution of threo- or erythro-1,4-dimercapto-2,3-butanediol.
Claim 21
Dependent Claim
26 words
A method for the preparation of thiol compounds wherein the water-insoluble polymer, activated as in claim 13, is directly treated with a solution of sodium sulphhydrate.
Claim 22
Dependent Claim
21 words
A method for the preparation of products as claimed in claim 10, wherein thiol polymers are exposed to an oxidizing reagent.
Claim 23
Dependent Claim
26 words
A method for the preparation of thiol compounds wherein the water-insoluble polymer, activated as in claim 14, is directly treated with a solution of sodium sulphhydrate.
Claim 24
Dependent Claim
26 words
A method for the preparation of thiol compounds wherein the water-insoluble polymer, activated as in claim 15, is directly treated with a solution of sodium sulphhydrate.
Claim 25
Dependent Claim
26 words
A method for the preparation of thiol compounds wherein the water-insoluble polymer, activated as in claim 16, is directly treated with a solution of sodium sulphhydrate.
Claim 26
Dependent Claim
69 words
A method wherein thiol compounds as claimed in claim 1 are used to prepare substitution products, in which the thiosulfate polymer is transformed in thiol polymer and H in the --SH group is thereafter replaced by organic radicals which can be introduced into thiols in solution and the thiol polymers undergo relations which involve the --SH groups of the polymer without alteration of the physical structure of said polymer.
Claim 27
Dependent Claim
15 words
A product as claimed in claim 1, characterized in that the polymer is polyvinyl alcohol.
Claim 28
Dependent Claim
14 words
A product as claimed in claim 1, characterized in that the polymer is cellulose.
Claim 29
Dependent Claim
16 words
A product as claimed in claim 1, characterized in that the polymer is a cross-linked polysaccharide.
Claim 30
Dependent Claim
17 words
A product as claimed in claim 1, characterized in that the polymer is an amino-substituted polyacryl amide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-09-12 | 1981-03-14 | 1981-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-09-12 | 1985-03-14 | 1985-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-09-12 | 1989-03-14 | 1989-09-13 | $7700.00 | Window Closed / Lapsed |