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US4045565A
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9-Hydroxy ellipticine
Assignee: Bpifrance Financement SA
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Filing: 1974-10-29
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Granted: 1977-08-30
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Expires: 1994-10-29
Abstract
Abstract 9-hydroxy ellipticine, preparation thereof, and use thereof for the treatment of leukemias and solid tumors.
Inventors
- 👤 Jean Bernard Le Pecq
- 👤 Claude Paoletti
- 👤 Nguyen Dat-Xuong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 22:29
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; A; A61; A61P; A61P35/00; A61P35/02; A61P9/00; A61P9/04
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
6 words
1.9-hydroxy ellipticine or 9-hydroxy-5,11-dimethyl-(6H)-pyrido [4,3-b] carbazole.
Claim 2
Dependent Claim
6 words
1.9-hydroxy ellipticine or 9-hydroxy-5,11-dimethyl-(6H)-pyrido [4,3-b] carbazole.
Claim 3
Dependent Claim
28 words
The composition of claim 1 crystallized in a substantially pure state in the form of orange-coloured crystals melting at a temperature substantially higher than 330° C with decomposition.
Claim 4
Dependent Claim
54 words
The composition of claim 1 crystallized with one molecule of methanol or water and having an -OH line at 3100 cm - 1 in its IR spectrum, a M + 262 peak in its mass spectrum and giving a Rf of 0.44 in thin layer chromatography on alumina using 28:2 benzene:ethanol mixture as eluant.
Claim 5
Dependent Claim
17 words
A process for preparing 9-hydroxy ellipticine comprising demethylating a 9-methoxy-ellipticine using a molar excess of pyridine hydrochloride.
Claim 6
Dependent Claim
17 words
A process for preparing 9-hydroxy ellipticine comprising demethylating a 9-methoxy-ellipticine using a molar excess of pyridine hydrochloride.
Claim 7
Dependent Claim
26 words
The process according to claim 4, wherein 3 to 11 parts by weight of pyridine hydrochloride are used for 1 part by weight of 9-methoxy ellipticine.
Claim 8
Dependent Claim
11 words
A pharmacautical composition comprising a therapeutically effective amount of 9-hydroxy ellipticine.
Claim 9
Dependent Claim
11 words
A pharmacautical composition comprising a therapeutically effective amount of 9-hydroxy ellipticine.
Claim 10
Dependent Claim
22 words
A pharmaceutical composition as claimed in claim 6, in the form of an injectable solution or solid preparations for administration per os.
Claim 11
Independent Claim
15 words
A method of cardiac treatment, which comprises using a therapeutically active amount of 9-hydroxy ellipticine.
Claim 12
Independent Claim
15 words
A method of cardiac treatment, which comprises using a therapeutically active amount of 9-hydroxy ellipticine.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-29 | 1981-02-28 | 1981-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-29 | 1985-02-28 | 1985-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-29 | 1989-02-28 | 1989-08-30 | $7700.00 | Window Closed / Lapsed |