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US4045550A Expired / Lapsed US ⏱️ 0.0 years remaining

Skin protective compositions

Assignee: Milacron Inc
•
Filing: 1974-02-04
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Granted: 1977-08-30
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Expires: 1994-02-04
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Abstract

Abstract Compositions effective for protecting the skin from dermatologic irritation are formed by incorporating a protective agent which is an organic compound containing two or more polar groups, e.g. carboxyl group, which are separated by at least 15 atoms the majority of which are carbon atoms and preferably containing a cyclic moiety of at least 5 atoms, e.g. the dimer of linoleic acid, in a pharmaceutically acceptable base.

Inventors

  • 👤 Ralph Kelly
  • 👤 Edmond Jean Ritter

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-03 23:29
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/84; A61K8/85; A61K8/30; A61K8/33; A61K8/37; A61Q; A61Q17/00; A61K2800/00; A61K2800/74; A61K2800/75

Claims Analysis

Total Claims: 21
Claim 1
Independent Claim 244 words
A skin protective lotion or creme consisting essentially of a skin irritation reducing effective amount of a protective agent and a non-aqueous emollient, humectant or surfactant; said lotion or creme capable of reducing skin irritation compared to said lotion or creme without protective agent when applied to the skin prior to contact with a skin irritant; said protective agent being dispersible in said lotion or creme; said protective agent containing two polar groups which are separated by a chain of at least 15 atoms a majority of which are carbon; said protective agent selected from the group consisting of: 1. esters and polyesters of the polymerized fatty acid product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said product containing 2 to 4 carboxyl groups; and an alcohol which is a. polyoxyalkylene ether containing 2 to 30 oxyalkylene units in which the alkylene radical contains 2 to 4 carbon atoms; b. a condensation product of alkylene oxide having 2 to 4 carbon atoms and polyamine having 2 to 4 amino groups and containing 2 to 8 carbon atoms in an aliphatic, cycloaliphatic or aromatic group; or c. a condensation product of ethylene oxide with a hydrophobic base formed by the condensation of propylene oxide with propylene glycol, having the general formula: ##STR35## wherein a is 1 to 150 b is 15 to 70 and c is 1 to 150; and 2.
Claim 2
Dependent Claim 244 words
A skin protective lotion or creme consisting essentially of a skin irritation reducing effective amount of a protective agent and a non-aqueous emollient, humectant or surfactant; said lotion or creme capable of reducing skin irritation compared to said lotion or creme without protective agent when applied to the skin prior to contact with a skin irritant; said protective agent being dispersible in said lotion or creme; said protective agent containing two polar groups which are separated by a chain of at least 15 atoms a majority of which are carbon; said protective agent selected from the group consisting of: 1. esters and polyesters of the polymerized fatty acid product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said product containing 2 to 4 carboxyl groups; and an alcohol which is a. polyoxyalkylene ether containing 2 to 30 oxyalkylene units in which the alkylene radical contains 2 to 4 carbon atoms; b. a condensation product of alkylene oxide having 2 to 4 carbon atoms and polyamine having 2 to 4 amino groups and containing 2 to 8 carbon atoms in an aliphatic, cycloaliphatic or aromatic group; or c. a condensation product of ethylene oxide with a hydrophobic base formed by the condensation of propylene oxide with propylene glycol, having the general formula: ##STR35## wherein a is 1 to 150 b is 15 to 70 and c is 1 to 150; and 2.
Claim 3
Dependent Claim 45 words
esters and polyesters of the hydrogenated polymerized product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said hydrogenated polymerized product containing 2 to 4 carboxyl groups; and an alcohol which is (a),
Claim 4
Dependent Claim 45 words
esters and polyesters of the hydrogenated polymerized product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said hydrogenated polymerized product containing 2 to 4 carboxyl groups; and an alcohol which is (a),
Claim 5
Dependent Claim 56 words
(b) or (c) above. 2. The skin protective lotion or creme of claim 1 in which said protective agent has the formula D--[COO(C.sub.2 H.sub.4 O).sub.2 C.sub.2 H.sub.5 ].sub.2 in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid.
Claim 6
Dependent Claim 52 words
The skin protective lotion or creme of claim 1 in which said protective agent has the formula ##STR36## in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and x is 4 to 10.
Claim 7
Dependent Claim 51 words
The skin protective lotion or creme of claim 1 in which said protective agent has the formula ##STR37## in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and n is about 10.
Claim 8
Dependent Claim 18 words
The skin protective lotion or creme of claim 1 in which said alcohol is as defined in (a).
Claim 9
Dependent Claim 18 words
The skin protective lotion or creme of claim 1 in which said alcohol is as defined in (b).
Claim 10
Dependent Claim 18 words
The skin protective lotion or creme of claim 1 in which said alcohol is defined as in (c).
Claim 11
Dependent Claim 20 words
The skin protective lotion or creme of claim 1 in which said polymerized fatty acid product comprises dimerized linoleic acid.
Claim 12
Dependent Claim 25 words
The skin protective lotion or creme of claim 1 in which said protective agent is as defined for 1(a), 1(b), or 1(c) of claim 1.
Claim 13
Dependent Claim 16 words
The skin protective lotion or creme of claim 1 in which said alcohol is a polyol.
Claim 14
Dependent Claim 243 words
A skin protective lotion or creme consisting essentially of a skin irritation reducing effective amount of a protective agent and a non-aqueous emollient, humectant or surfactant; said lotion or creme capable of reducing skin irritation compared to said lotion or creme without protective agent when applied to the skin prior to contact with a skin irritant; said protective agent being dispersible in said lotion or creme; said protective agent containing two polar groups which are separated by a chain of at least 15 atoms a majority of which are carbon; said protective agent selected from the group consisting of: 2. esters and polyesters of the polymerized fatty acid product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said product containing 2 to 4 carboxyl groups; and a polyol which is a. a polyoxyalkylene ether containing 2 to 30 oxyalkylene units in which the alkylene radical contains 2 to 4 carbon atoms; b. a condensation product of alkylene oxide having 2 to 4 carbon atoms and polyamine having 2 to 4 amino groups and containing 2 to 8 carbon atoms in an aliphatic, cycloaliphatic or aromatic group; or c. a condensation product of ethylene oxide with a hydrophobic base formed by the condensation of propylene oxide with propylene glycol, having the general formula: ##STR38## wherein a is 1 to 150 b is 15 to 70 and c is 1 to 150.
Claim 15
Dependent Claim 243 words
A skin protective lotion or creme consisting essentially of a skin irritation reducing effective amount of a protective agent and a non-aqueous emollient, humectant or surfactant; said lotion or creme capable of reducing skin irritation compared to said lotion or creme without protective agent when applied to the skin prior to contact with a skin irritant; said protective agent being dispersible in said lotion or creme; said protective agent containing two polar groups which are separated by a chain of at least 15 atoms a majority of which are carbon; said protective agent selected from the group consisting of: 2. esters and polyesters of the polymerized fatty acid product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said product containing 2 to 4 carboxyl groups; and a polyol which is a. a polyoxyalkylene ether containing 2 to 30 oxyalkylene units in which the alkylene radical contains 2 to 4 carbon atoms; b. a condensation product of alkylene oxide having 2 to 4 carbon atoms and polyamine having 2 to 4 amino groups and containing 2 to 8 carbon atoms in an aliphatic, cycloaliphatic or aromatic group; or c. a condensation product of ethylene oxide with a hydrophobic base formed by the condensation of propylene oxide with propylene glycol, having the general formula: ##STR38## wherein a is 1 to 150 b is 15 to 70 and c is 1 to 150.
Claim 16
Dependent Claim 64 words
The skin protective lotion or creme of claim 11 in which said protective agent has the formula ##STR39## in which D is the carboxyl free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; X is from about 2 to about 10; and y is from about 2 to about 15.
Claim 17
Dependent Claim 52 words
The skin protective lotion or creme of claim 11 in which said protective agent has the formula ##STR40## in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and x is 2 to 30.
Claim 18
Dependent Claim 54 words
The skin protective lotion or creme of claim 11 in which said protective agent has the formula ##STR41## in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and x is about 6 to about 25.
Claim 19
Dependent Claim 52 words
The skin protective lotion or creme of claim 11 in which said protective agent has the formula ##STR42## in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and x is 10 to 20.
Claim 20
Dependent Claim 57 words
The skin protective lotion or creme of claim 11 in which said protective agent has the formula C.sub.17 H.sub.35 OCO--D--CO[OC.sub.2 H.sub.4 ].sub.x OH in which D is the carboxyl free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and x is about 9.
Claim 21
Dependent Claim 34 words
The skin protective lotion or creme of claim 11 in which said protective agent is the esterification product of the dimer of linoleic acid and polyethylene glycol having a molecular weight of about 400.

References Cited (Backward Citations)

US1913631A Cited
US2129836A Cited
US3157629A Cited
US3100784A Cited
NL6513582A Cited
US3630934A Cited
US3493534A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-08-29 1981-02-28 1981-08-30 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-08-29 1985-02-28 1985-08-30 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-08-29 1989-02-28 1989-08-30 $7700.00 Window Closed / Lapsed

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