Patent US3923334A successfully refreshed from Google Patents.
Patent US4045550A successfully refreshed from Google Patents.
US4045550A
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US
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Skin protective compositions
Assignee: Milacron Inc
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Filing: 1974-02-04
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Granted: 1977-08-30
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Expires: 1994-02-04
Abstract
Abstract Compositions effective for protecting the skin from dermatologic irritation are formed by incorporating a protective agent which is an organic compound containing two or more polar groups, e.g. carboxyl group, which are separated by at least 15 atoms the majority of which are carbon atoms and preferably containing a cyclic moiety of at least 5 atoms, e.g. the dimer of linoleic acid, in a pharmaceutically acceptable base.
Inventors
- 👤 Ralph Kelly
- 👤 Edmond Jean Ritter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 23:29
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/84; A61K8/85; A61K8/30; A61K8/33; A61K8/37; A61Q; A61Q17/00; A61K2800/00; A61K2800/74; A61K2800/75
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
244 words
A skin protective lotion or creme consisting essentially of a skin irritation reducing effective amount of a protective agent and a non-aqueous emollient, humectant or surfactant; said lotion or creme capable of reducing skin irritation compared to said lotion or creme without protective agent when applied to the skin prior to contact with a skin irritant; said protective agent being dispersible in said lotion or creme; said protective agent containing two polar groups which are separated by a chain of at least 15 atoms a majority of which are carbon; said protective agent selected from the group consisting of: 1. esters and polyesters of the polymerized fatty acid product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said product containing 2 to 4 carboxyl groups; and an alcohol which is a. polyoxyalkylene ether containing 2 to 30 oxyalkylene units in which the alkylene radical contains 2 to 4 carbon atoms; b. a condensation product of alkylene oxide having 2 to 4 carbon atoms and polyamine having 2 to 4 amino groups and containing 2 to 8 carbon atoms in an aliphatic, cycloaliphatic or aromatic group; or c. a condensation product of ethylene oxide with a hydrophobic base formed by the condensation of propylene oxide with propylene glycol, having the general formula: ##STR35## wherein a is 1 to 150 b is 15 to 70 and c is 1 to 150; and 2.
Claim 2
Dependent Claim
244 words
A skin protective lotion or creme consisting essentially of a skin irritation reducing effective amount of a protective agent and a non-aqueous emollient, humectant or surfactant; said lotion or creme capable of reducing skin irritation compared to said lotion or creme without protective agent when applied to the skin prior to contact with a skin irritant; said protective agent being dispersible in said lotion or creme; said protective agent containing two polar groups which are separated by a chain of at least 15 atoms a majority of which are carbon; said protective agent selected from the group consisting of: 1. esters and polyesters of the polymerized fatty acid product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said product containing 2 to 4 carboxyl groups; and an alcohol which is a. polyoxyalkylene ether containing 2 to 30 oxyalkylene units in which the alkylene radical contains 2 to 4 carbon atoms; b. a condensation product of alkylene oxide having 2 to 4 carbon atoms and polyamine having 2 to 4 amino groups and containing 2 to 8 carbon atoms in an aliphatic, cycloaliphatic or aromatic group; or c. a condensation product of ethylene oxide with a hydrophobic base formed by the condensation of propylene oxide with propylene glycol, having the general formula: ##STR35## wherein a is 1 to 150 b is 15 to 70 and c is 1 to 150; and 2.
Claim 3
Dependent Claim
45 words
esters and polyesters of the hydrogenated polymerized product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said hydrogenated polymerized product containing 2 to 4 carboxyl groups; and an alcohol which is (a),
Claim 4
Dependent Claim
45 words
esters and polyesters of the hydrogenated polymerized product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said hydrogenated polymerized product containing 2 to 4 carboxyl groups; and an alcohol which is (a),
Claim 5
Dependent Claim
56 words
(b) or (c) above. 2. The skin protective lotion or creme of claim 1 in which said protective agent has the formula D--[COO(C.sub.2 H.sub.4 O).sub.2 C.sub.2 H.sub.5 ].sub.2 in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid.
Claim 6
Dependent Claim
52 words
The skin protective lotion or creme of claim 1 in which said protective agent has the formula ##STR36## in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and x is 4 to 10.
Claim 7
Dependent Claim
51 words
The skin protective lotion or creme of claim 1 in which said protective agent has the formula ##STR37## in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and n is about 10.
Claim 8
Dependent Claim
18 words
The skin protective lotion or creme of claim 1 in which said alcohol is as defined in (a).
Claim 9
Dependent Claim
18 words
The skin protective lotion or creme of claim 1 in which said alcohol is as defined in (b).
Claim 10
Dependent Claim
18 words
The skin protective lotion or creme of claim 1 in which said alcohol is defined as in (c).
Claim 11
Dependent Claim
20 words
The skin protective lotion or creme of claim 1 in which said polymerized fatty acid product comprises dimerized linoleic acid.
Claim 12
Dependent Claim
25 words
The skin protective lotion or creme of claim 1 in which said protective agent is as defined for 1(a), 1(b), or 1(c) of claim 1.
Claim 13
Dependent Claim
16 words
The skin protective lotion or creme of claim 1 in which said alcohol is a polyol.
Claim 14
Dependent Claim
243 words
A skin protective lotion or creme consisting essentially of a skin irritation reducing effective amount of a protective agent and a non-aqueous emollient, humectant or surfactant; said lotion or creme capable of reducing skin irritation compared to said lotion or creme without protective agent when applied to the skin prior to contact with a skin irritant; said protective agent being dispersible in said lotion or creme; said protective agent containing two polar groups which are separated by a chain of at least 15 atoms a majority of which are carbon; said protective agent selected from the group consisting of: 2. esters and polyesters of the polymerized fatty acid product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said product containing 2 to 4 carboxyl groups; and a polyol which is a. a polyoxyalkylene ether containing 2 to 30 oxyalkylene units in which the alkylene radical contains 2 to 4 carbon atoms; b. a condensation product of alkylene oxide having 2 to 4 carbon atoms and polyamine having 2 to 4 amino groups and containing 2 to 8 carbon atoms in an aliphatic, cycloaliphatic or aromatic group; or c. a condensation product of ethylene oxide with a hydrophobic base formed by the condensation of propylene oxide with propylene glycol, having the general formula: ##STR38## wherein a is 1 to 150 b is 15 to 70 and c is 1 to 150.
Claim 15
Dependent Claim
243 words
A skin protective lotion or creme consisting essentially of a skin irritation reducing effective amount of a protective agent and a non-aqueous emollient, humectant or surfactant; said lotion or creme capable of reducing skin irritation compared to said lotion or creme without protective agent when applied to the skin prior to contact with a skin irritant; said protective agent being dispersible in said lotion or creme; said protective agent containing two polar groups which are separated by a chain of at least 15 atoms a majority of which are carbon; said protective agent selected from the group consisting of: 2. esters and polyesters of the polymerized fatty acid product obtained from the polymerization of 2 to 4 molecules of a monomeric ethylenically unsaturated C 12 to C 26 fatty acid, said product containing 2 to 4 carboxyl groups; and a polyol which is a. a polyoxyalkylene ether containing 2 to 30 oxyalkylene units in which the alkylene radical contains 2 to 4 carbon atoms; b. a condensation product of alkylene oxide having 2 to 4 carbon atoms and polyamine having 2 to 4 amino groups and containing 2 to 8 carbon atoms in an aliphatic, cycloaliphatic or aromatic group; or c. a condensation product of ethylene oxide with a hydrophobic base formed by the condensation of propylene oxide with propylene glycol, having the general formula: ##STR38## wherein a is 1 to 150 b is 15 to 70 and c is 1 to 150.
Claim 16
Dependent Claim
64 words
The skin protective lotion or creme of claim 11 in which said protective agent has the formula ##STR39## in which D is the carboxyl free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; X is from about 2 to about 10; and y is from about 2 to about 15.
Claim 17
Dependent Claim
52 words
The skin protective lotion or creme of claim 11 in which said protective agent has the formula ##STR40## in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and x is 2 to 30.
Claim 18
Dependent Claim
54 words
The skin protective lotion or creme of claim 11 in which said protective agent has the formula ##STR41## in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and x is about 6 to about 25.
Claim 19
Dependent Claim
52 words
The skin protective lotion or creme of claim 11 in which said protective agent has the formula ##STR42## in which D is the carboxyl-free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and x is 10 to 20.
Claim 20
Dependent Claim
57 words
The skin protective lotion or creme of claim 11 in which said protective agent has the formula C.sub.17 H.sub.35 OCO--D--CO[OC.sub.2 H.sub.4 ].sub.x OH in which D is the carboxyl free residue of the dimer obtained from the polymerization of 2 molecules of a C 12 -C 26 monomeric ethylenically unsaturated fatty acid; and x is about 9.
Claim 21
Dependent Claim
34 words
The skin protective lotion or creme of claim 11 in which said protective agent is the esterification product of the dimer of linoleic acid and polyethylene glycol having a molecular weight of about 400.
References Cited (Backward Citations)
US1913631A
Cited
US2129836A
Cited
US3157629A
Cited
US3100784A
Cited
NL6513582A
Cited
US3630934A
Cited
US3493534A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-29 | 1981-02-28 | 1981-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-29 | 1985-02-28 | 1985-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-29 | 1989-02-28 | 1989-08-30 | $7700.00 | Window Closed / Lapsed |