Patent US4045420A successfully refreshed from Google Patents.
US4045420A
Expired / Lapsed
US
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Non-oxo-carbonyl containing benzoyl ecgonine and cocaine compounds polypeptide and derivatives thereof
Assignee: Syva Co
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Filing: 1973-05-29
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Granted: 1977-08-30
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Expires: 1993-05-29
Abstract
Abstract Non-oxo-carbonyl substituted derivatives of cocaine are provided for conjugation with other compounds to provide reagents for use in a diversity of immunoassay techniques. Specifically, carboxy or imidoyl derivatives are provided which may be conjugated with antigens for use in the preparation of antibodies to cocaine or conjugated with detector molecules for use in the qualitative or quantitative determination of the presence of cocaine.
Inventors
- 👤 Michael J. Soffer
- 👤 Richard S. Schneider
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 22:00
CPC Classifications
C; C07; C07D; C07D451/00; C07D451/02; C07D451/04; C07D451/06; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K47/64; A61K47/646; C07D451/12; C07K; C07K16/00; C07K16/44; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/94; G01N33/946; G01R; G01R33/00; G01R33/20; G01R33/28; G01R33/281; Y; Y10; Y10S; Y10S435/00; Y10S435/961; Y10S436/00; Y10S436/803; Y10S436/815; Y10S436/816; Y10S436/823; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
84 words
A nor-tropane substituted polypeptide including proteins selected from the group consisting of compounds of the formula: ##STR7## wherein PP is an antigenic polypeptide, including proteins; n is at least one; A 1 is hydrogen or methyl; Y 1 and Y 2 are hydrocarbylene of from 1 to 10 carbon atoms; W 1 and W 2 are oxygen or imino; and Z 1 is hydrogen or benzoyl, wherein the nor-tropane is bonded to the polypeptide through an amino group to form an amide or amidine.
Claim 2
Dependent Claim
84 words
A nor-tropane substituted polypeptide including proteins selected from the group consisting of compounds of the formula: ##STR7## wherein PP is an antigenic polypeptide, including proteins; n is at least one; A 1 is hydrogen or methyl; Y 1 and Y 2 are hydrocarbylene of from 1 to 10 carbon atoms; W 1 and W 2 are oxygen or imino; and Z 1 is hydrogen or benzoyl, wherein the nor-tropane is bonded to the polypeptide through an amino group to form an amide or amidine.
Claim 3
Dependent Claim
27 words
A compound according to claim 1 which is of formula (a), Y 1 is aliphatic of from 1 to 6 carbon atoms, and W 1 is oxygen.
Claim 4
Dependent Claim
31 words
A compound according to claim 1, which is of formula (a), Y 1 is aliphatic of from 1 to 6 carbon atoms, W 1 is imino, and Z 1 is benzoyl.
Claim 5
Dependent Claim
20 words
A compound according to claim 1, which is of formula (b), Y 2 is phenylene and W 2 is oxygen.
Claim 6
Dependent Claim
21 words
A compound according to claim 1, which is of formula (b), wherein Y 2 is phenylene and W 2 is imino.
Claim 7
Dependent Claim
23 words
A conjugate of N-carboxymethyl nor-cocaine with an antigenic polypeptide, wherein said carboxymethyl group is bonded to said antigenic polypeptide through an amide link.
Claim 8
Dependent Claim
23 words
A conjugate of N-carboxymethyl nor-cocaine with an antigenic polypeptide, wherein said carboxymethyl group is bonded to said antigenic polypeptide through an amide link.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-29 | 1981-02-28 | 1981-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-29 | 1985-02-28 | 1985-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-29 | 1989-02-28 | 1989-08-30 | $7700.00 | Window Closed / Lapsed |