Patent US4044147A successfully refreshed from Google Patents.
US4044147A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N-(acyl)-p-amino-N'-(monosubstituted)-benzamide anti-ulcer agents
Assignee: Pfizer Inc
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Filing: 1976-05-26
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Granted: 1977-08-23
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Expires: 1996-05-26
Abstract
Abstract The preparation of novel N-(acyl)-p-amino-N'-(monosubstituted) benzamides by modified Schotten-Baumann reaction of the corresponding p-aminobenzamides is described. These compounds are effective anti-ulcer agents.
Inventors
- 👤 Albin J. Nelson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 15:27
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/81; A; A61; A61P; A61P1/00; A61P1/04; C07D213/82
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
123 words
A compound of the formula ##STR35## wherein: R 1 is selected from the group consisting of n-alkyl having from seven to eighteen carbon atoms, phenyl, benzyl and phenylethyl, R 2 is selected from the group consisting of --(CH 2 ) n CO 2 R 3 , --(CHOR 4 ) n CO 2 R 3 and ##STR36## said Z substituent being --(CH 2 ) u CO 2 R 3 , R 3 is hydrogen or alkyl having from one to five carbon atoms, R 4 is hydrogen or acetyl; n is an integer from one to four; u is 0 or an integer from one to two; and the alkali, alkaline earth and ammonium salts of those compounds having at least one carboxylate group.
Claim 2
Dependent Claim
123 words
A compound of the formula ##STR35## wherein: R 1 is selected from the group consisting of n-alkyl having from seven to eighteen carbon atoms, phenyl, benzyl and phenylethyl, R 2 is selected from the group consisting of --(CH 2 ) n CO 2 R 3 , --(CHOR 4 ) n CO 2 R 3 and ##STR36## said Z substituent being --(CH 2 ) u CO 2 R 3 , R 3 is hydrogen or alkyl having from one to five carbon atoms, R 4 is hydrogen or acetyl; n is an integer from one to four; u is 0 or an integer from one to two; and the alkali, alkaline earth and ammonium salts of those compounds having at least one carboxylate group.
Claim 3
Dependent Claim
10 words
A compound of claim 1 wherein R 1 is n-alkyl.
Claim 4
Dependent Claim
10 words
A compound of claim 2 wherein R 2 is ##STR37##
Claim 5
Dependent Claim
18 words
A compound of claim 2 wherein R 2 is --(CH 2 ) n CO 2 R 3 .
Claim 6
Dependent Claim
21 words
The compound of claim 4 wherein R 1 is n-decyl and R 2 is --(CH 2 ) 2 CO 2 H.
Claim 7
Dependent Claim
23 words
A composition for peptic ulcer control comprising an effective amount of a compound of claim 1 in admixture with a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
34 words
A method of controlling peptic ulcers in an animal which comprises intraperitoneally or orally administering to an animal in need of such control a peptic ulcer controlling amount of a compound of claim 1.
Claim 9
Dependent Claim
15 words
A method of claim 7 wherein R 1 is n-alkyl and R 2 is ##STR38##
Claim 10
Dependent Claim
23 words
A method of claim 7 wherein R 1 is n-alkyl and R 2 is --(CH 2 ) n CO 2 R 3 .
Claim 11
Dependent Claim
21 words
A method of claim 9 wherein R 1 is n-decyl and R 2 is --(CH 2 ) 2 CO 2 H.
References Cited (Backward Citations)
US3780090A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-22 | 1981-02-21 | 1981-08-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-22 | 1985-02-21 | 1985-08-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-22 | 1989-02-21 | 1989-08-23 | $7700.00 | Window Closed / Lapsed |