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Patent US4042701A successfully refreshed from Google Patents.
US4042701A
Expired / Lapsed
US
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7,7-Diphenyl-1,4-oxazepinoalkyl-dicarboximides
Assignee: Novartis Corp
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Filing: 1975-09-22
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Granted: 1977-08-16
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Expires: 1995-09-22
Abstract
Abstract N-(7,7-Diphenyl-hexahydro-1,4-oxazepin-4-yl-alkyl)-dicarboximides, e.g. those of the formula: ##STR1## AND ACID ADDITION SALTS THEREOF ARE ANTIASTHMATICS.
Inventors
- 👤 Robert Mathews Bowman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 19:49
CPC Classifications
C; C07; C07C; C07C255/00; C07D; C07D267/00; C07D267/02; C07D267/08; C07D267/10
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
131 words
An N-(7,7-diphenyl-hexahydro-1,4-oxazepin-4-yl-alkyl)-dicarboximide corresponding to the formula ##STR8## wherein each of alk and alk' is lower alkylene separating the adjacent atoms by 2 carbon atoms, alk" is lower alkylene separating the adjacent atoms by at least 2 carbon atoms, each of Ph and Ph' is phenyl, unsubstituted or substituted by up to three members of lower alkyl, lower alkoxy, lower alkylmercapto, hydroxy, halogeno or trifluoromethyl, and A is lower alkylene, lower alkenylene, 5 to 7 ring-membered mono- or bicyclic 1,2- or 1,3-(cycloalkylene or cycloalkenylene), 5 to 7 ring-membered spirocycloalkane-lower alkylene or 1,2-phenylene, said mono- or bicyclic 1, 2- or 1,3-(cycloalkylene or cycloalkenylene) are unsubstituted or substituted by up to three lower alkyls, and said 1,2-phenylene radical is substituted in the same manner as Ph, or a therapeutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
131 words
An N-(7,7-diphenyl-hexahydro-1,4-oxazepin-4-yl-alkyl)-dicarboximide corresponding to the formula ##STR8## wherein each of alk and alk' is lower alkylene separating the adjacent atoms by 2 carbon atoms, alk" is lower alkylene separating the adjacent atoms by at least 2 carbon atoms, each of Ph and Ph' is phenyl, unsubstituted or substituted by up to three members of lower alkyl, lower alkoxy, lower alkylmercapto, hydroxy, halogeno or trifluoromethyl, and A is lower alkylene, lower alkenylene, 5 to 7 ring-membered mono- or bicyclic 1,2- or 1,3-(cycloalkylene or cycloalkenylene), 5 to 7 ring-membered spirocycloalkane-lower alkylene or 1,2-phenylene, said mono- or bicyclic 1, 2- or 1,3-(cycloalkylene or cycloalkenylene) are unsubstituted or substituted by up to three lower alkyls, and said 1,2-phenylene radical is substituted in the same manner as Ph, or a therapeutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
104 words
A compound as claimed in claim 1, in which formula each of alk and alk' is lower alkylene separating the adjacent atoms by 2 carbon atoms, alk" is lower alkylene separating the adjacent atoms by at least 2 carbon atoms, each of Ph and Ph' is phenyl, (lower alkyl)-phenyl, mono-, di- or tri-(lower alkoxy)-phenyl, (lower alkylmercapto, hydroxy, halogeno or trifluoromethyl)-phenyl, and A is lower alkylene, lower alkenylene, 5 to 7 ring-memberd mono- or bicyclic 1,2- or 1,3-(cycloalkylene or cycloalkenylene), 5 to 7 ring-membered 2-spirocycloalkane-1,3- propylene, 1,2-phenylene, (lower alkyl, lower alkoxy, lower alkylmercapto, hydroxy, halogeno or trifluoromethyl)-1,2-phenylene, or a therapeutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
73 words
A compound as claimed in claim 1, in which formula each of alk and alk' is ethylene or 1,2-propylene, alk" is ethylene, 1,3-propylene or 1,4-butylene, each of Ph and Ph' is phenyl or (lower alkyl)-phenyl, and A is ethylene, 1,3-propylene, 2,2-di-(methyl, ethyl, n-proply or n-butyl)-1,3-propylene, 1,4-butylene or 1,4-but-2-enylene, 1,2- or 1,3-cyclopentylene or cyclohexylene, 1,2,2-trimethyl-1,3-cyclopentylene, 2-methyl-1,3-cyclohexylene, 3,6-ethano-1,2-cyclohexylene or -cyclo-4-hexenylene, 2-spirocyclopentane or --hexane-1,3-propylene, 1,2-phenylene or (lower alkyl)-1,2-phenylene, or a therapeutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
37 words
A compound as claimed in claim 1 and corresponding to the formula ##STR9## wherein m is an integer from 2 to 4 and n such from 4 to 5, or a therapeutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
27 words
A compound as claimed in claim 4, in which formula m is 3 or 4 and n is four, or a therapeutically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
19 words
A compound as claimed in claim 5 and being the N-[3-(7,7-diphenyl-hexahydro-1,4-oxazepin-4-yl)-propyl]-β,β-tetramethylene-glutarimide, or a therapeutically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
30 words
A pharamaceutical composition for treating asthmatic, allergic and inflammatory conditions in mammals comprising a pharmacologically effective amount of a compound as claimed in claim 1, together with a pharmaceutical excipient.
Claim 9
Dependent Claim
28 words
A method of treating asthmatic, allergic and inflammatory conditions in mammals, which consists in administering to said mammals enterally or parenterally a composition as claimed in claim 7.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-15 | 1981-02-14 | 1981-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-15 | 1985-02-14 | 1985-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-15 | 1989-02-14 | 1989-08-16 | $7700.00 | Window Closed / Lapsed |