US4042689A
Expired / Lapsed
US
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Alkylated orgotein
Assignee: GT Biopharma Inc
•
Filing: 1975-09-09
•
Granted: 1977-08-16
•
Expires: 1995-09-09
Abstract
Abstract N-alkylated orgotein, like the native protein, possesses superoxide dismutase and anti-inflammatory activity.
Inventors
- 👤 Wolfgang Huber
- 👤 Mark G. Saifer
- 👤 Lewis D. Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 18:13
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/0004; C12N9/0089; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
22 words
Alkylated orgotein wherein an alkyl group of up to 8 carbon atoms is present on at least one lysine ε-amino group thereof.
Claim 2
Dependent Claim
22 words
Alkylated orgotein wherein an alkyl group of up to 8 carbon atoms is present on at least one lysine ε-amino group thereof.
Claim 3
Dependent Claim
11 words
The alkylated orgotein of claim 1, wherein the orgotein is bovine.
Claim 4
Dependent Claim
15 words
The alkylated orgotein of claim 1, having at least 10 alkylated ε-amino groups per molecule.
Claim 5
Dependent Claim
15 words
The alkylated orgotein of claim 1, having at least 18 alkylated ε-amino groups per molecule.
Claim 6
Dependent Claim
11 words
The alkylated orgotein of claim 3, wherein the orgotein is bovine.
Claim 7
Dependent Claim
16 words
The alkylated orgotein of claim 1, wherein the alkylating group is alkyl of 1-4 carbon atoms.
Claim 8
Dependent Claim
12 words
The alkylated orgotein of claim 1, wherein the alkylating group is methyl.
Claim 9
Dependent Claim
11 words
The alkylated orgotein of claim 6, wherein the orgotein is bovine.
Claim 10
Dependent Claim
15 words
The alkylated orgotein of claim 6, having at least 10 alkylated ε-amino groups per molecule.
Claim 11
Dependent Claim
15 words
The alkylated orgotein of claim 6, having at least 18 alkylated ε-amino groups per molecule.
Claim 12
Dependent Claim
12 words
The alkylated orgotein of claim 8, wherein the alkyl group is methyl.
Claim 13
Dependent Claim
15 words
The alkylated orgotein of claim 11, having at least 10 alkylated ε-amino groups per molecule.
Claim 14
Dependent Claim
15 words
The alkylated orgotein of claim 11, having at least 18 alkylated ε-amino groups per molecule.
Claim 15
Dependent Claim
27 words
A pharmaceutical composition having antiinflammatory activity comprising, in admixture with a pharmaceutically acceptable carrier, an antiinflammatorily effective unit dosage amount of an alkylated orgotein of claim 1.
Claim 16
Dependent Claim
11 words
The pharmaceutical composition according to claim 14 in sterile injectable form.
References Cited (Backward Citations)
US3687927A
Cited
US3758682A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-15 | 1981-02-14 | 1981-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-15 | 1985-02-14 | 1985-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-15 | 1989-02-14 | 1989-08-16 | $7700.00 | Window Closed / Lapsed |