US4042677A
Expired / Lapsed
US
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Technetium-99m labeled radiodiagnostic agents and method of preparation
Assignee: CINTICHEM Inc
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Filing: 1975-12-01
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Granted: 1977-08-16
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Expires: 1995-12-01
Abstract
Abstract A method of preparing improved technetium-99m labeled radiodiagnostic agents by reducing technetium-99m with stannous tartrate. Such radiodiagnostic agents are useful in scintigraphic examinations of the bone and lung.
Inventors
- 👤 Victor Joseph Molinski
- 👤 Joseph Arthur Wilczewski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 04:27
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; A61K51/02; A61K51/04; A61K51/08; A61K51/081; A61K51/1282; A61K2123/00
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
49 words
A stable, non-radioactive carrier suitable for cardiac studies, blood pool and brain scanning when labeled with 99m TC, said carrier comprising human serum albumin (HSA) and strannous tartrate, the ratio by weight of said HSA to stannous tartrate being between about 50 to 1 and about 150 to 1.
Claim 2
Dependent Claim
49 words
A stable, non-radioactive carrier suitable for cardiac studies, blood pool and brain scanning when labeled with 99m TC, said carrier comprising human serum albumin (HSA) and strannous tartrate, the ratio by weight of said HSA to stannous tartrate being between about 50 to 1 and about 150 to 1.
Claim 3
Dependent Claim
15 words
A carrier as defined in claim 1 wherein said ratio is about 100 to 1.
Claim 4
Independent Claim
105 words
A method of preparing a stable, nonradioactive carrier suitable for cardiac studies, blood pool and brain scanning when labeled with 99m Tc, said method comprising: dissolving stannous tartrate in a non-oxidizing acid to form a stannous tartrate solution; adjusting the pH of said stannous tartrate solution to a pH between about 2 and about 4; adjusting the pH of a human serum albumin (HSA) solution to a pH between about 2 and about 4; contacting said stannous tartrate solution with said HSA solution to form a stannous tartrate-HSA solution; and adjusting the pH of said stannous tartrate-HSA solution to between about 2 and about 4.
Claim 5
Independent Claim
105 words
A method of preparing a stable, nonradioactive carrier suitable for cardiac studies, blood pool and brain scanning when labeled with 99m Tc, said method comprising: dissolving stannous tartrate in a non-oxidizing acid to form a stannous tartrate solution; adjusting the pH of said stannous tartrate solution to a pH between about 2 and about 4; adjusting the pH of a human serum albumin (HSA) solution to a pH between about 2 and about 4; contacting said stannous tartrate solution with said HSA solution to form a stannous tartrate-HSA solution; and adjusting the pH of said stannous tartrate-HSA solution to between about 2 and about 4.
Claim 6
Dependent Claim
37 words
A method as defined in claim 3 wherein the pH of said stannous tartrate-HSA solution is adjusted with the addition of a pH adjusting solution selected from the group consisting of sodium hydroxide and human serum albumin.
Claim 7
Dependent Claim
16 words
A method as defined in claim 4 wherein said pH adjusting solution is human serum albumin.
Claim 8
Dependent Claim
31 words
A method as defined in claim 3 wherein the pH of said stannous tartrate solution is (said) adjusted with an aqueous solution which is substantially free of entrained or dissolved oxygen.
Claim 9
Dependent Claim
16 words
A method as defined in claim 6 wherein said aqueous solution is water or sodium hydroxide.
Claim 10
Dependent Claim
30 words
A method as defined in claim 3 further including before said stannous tartrate solution is contacted with said HSA solution; adjusting the pH of said HSA solution to about 3.
Claim 11
Dependent Claim
35 words
A method as defined in claim 3 further including after said stannous tartrate solution has been contacted with said HSA solution; adusting the pH of said HSA solution to about 2.5 with a non-oxidizing acid.
Claim 12
Dependent Claim
24 words
A method as defined in claim 3 wherein said non-oxidizing acid is selected from the group consisting of hydrochloric, acetic, sulfuric and phosphoric acid.
Claim 13
Dependent Claim
14 words
A method as defined in claim 10 wherein said non-oxidizing acid is hydrochloric acid.
Claim 14
Dependent Claim
15 words
A method as defined in claim 11 wherein said non-oxidizing acid is concentrated hydrochloric acid.
Claim 15
Dependent Claim
47 words
A method as defined in claim 3 further including after the pH of said stannous tartrate-HSA solution is adjusted to between about 2 and about 4; lyophilizing said stannous tartrate-HSA solution at a shelf temperatue between about 0° C and about 30° C to form a solid.
Claim 16
Dependent Claim
15 words
A method as defined in claim 13 wherein said shelf temperature is about 20° C.
Claim 17
Dependent Claim
71 words
A method as defined in claim 13 further including after said lyophilization of said stannous tartrate-HSA solution; redissolving said lyophilized solid with an amount of aqueous solution sufficient to replace the water removed during said lyophilization step; and contacting said redissolved solution with a sufficient amount of a saline solution of Na 99m TcO 4 to form a 99m Tc-labeled radiodiagnostic agent suitable for cardiac studies, blood pool and brain scanning.
Claim 18
Dependent Claim
52 words
A method as defined in claim 3 further including after said pH adjustment of said stannous tartrate-HSA solution; contacting said stannous tartrate-HSA solution with a sufficient amount of a saline solution of Na 99m TcO 4 to form a 99m Tc-labeled radiodiagnostic agent suitable for cardian studies, blood pool and brain scanning.
Claim 19
Dependent Claim
49 words
A method as defined in claim 13 further including after said lyophilization of said stannous tartrate-HSA solution; contacting said lyophilized solid with a sufficient amount of saline solution of Na 99m TcO 4 to form a 99m Tc-labeled radiodiagnostic agent suitable for cardiac studies, blood pool and brain scanning.
Claim 20
Dependent Claim
67 words
A radiodiagnostic agent suitable for cardiac studies, blood pool and brain scanning and having a pH between about 2 and about 4, said agent comprising a mixture of stannous tartrate, human serum albumin and a saline solutin of Na 99m TcO 4 , the ratio by weight of said human serum albumin to said stannous tartrate being between about 50 to 1 and about 150 to 1.
Claim 21
Dependent Claim
67 words
A radiodiagnostic agent suitable for cardiac studies, blood pool and brain scanning and having a pH between about 2 and about 4, said agent comprising a mixture of stannous tartrate, human serum albumin and a saline solutin of Na 99m TcO 4 , the ratio by weight of said human serum albumin to said stannous tartrate being between about 50 to 1 and about 150 to 1.
Claim 22
Dependent Claim
15 words
An agent as defined in claim 18 wherein said ratio is about 100 to 1.
References Cited (Backward Citations)
US3862299A
Cited
US3872226A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-15 | 1981-02-14 | 1981-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-15 | 1985-02-14 | 1985-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-15 | 1989-02-14 | 1989-08-16 | $7700.00 | Window Closed / Lapsed |