US4042676A
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Technetium-99m labeled radiodiagnostic agents for liver and bone marrow scanning and method of preparation
Assignee: CINTICHEM Inc
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Filing: 1975-10-09
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Granted: 1977-08-16
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Expires: 1995-10-09
Abstract
Abstract An improved technetium-99m labeled colloid and method of preparation comprising reducing technetium-99m with stannous oxalate and stabilizing with sodium phytate. This radiodiagnostic agent is useful in the scintigraphic examination of the recticuloendothelial system, particularly the liver. In addition, by autoclaving this product with saline, it becomes a superior bone marrow scanning agent.
Inventors
- 👤 Victor Joseph Molinski
- 👤 Frank Raymond Peacock
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 05:40
CPC Classifications
G; G21; G21H; G21H5/00; G21H5/02; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; C; C08; C08C; C08C19/00; C08C19/04; C08C19/06; C08C19/20; C08K; C08K3/00; C08K3/34; C08K3/36; C08K5/00; C08K5/54; C08K5/548; C08L; C08L15/00; C08L9/00; C08L9/06; A61K2123/00
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
40 words
A stable, non-radioactive carrier suitable for liver scanning when labeled with 99m Tc, said carrier comprising sodium phytate; and stannous ion chelated with oxalate, the ratio by weight of said phytate to chelate being at least about 1 to 1.
Claim 2
Dependent Claim
40 words
A stable, non-radioactive carrier suitable for liver scanning when labeled with 99m Tc, said carrier comprising sodium phytate; and stannous ion chelated with oxalate, the ratio by weight of said phytate to chelate being at least about 1 to 1.
Claim 3
Dependent Claim
17 words
A carrier as defined in claim 1 wherein said ratio is at least about 3 to 1.
Claim 4
Dependent Claim
17 words
A carrier as defined in claim 2 wherein said ratio is at least about 13 to 1.
Claim 5
Dependent Claim
27 words
A carrier as defined in claim 2 wherein said ratio is between about 3 to 1 and about 20 to 1 and said pH is about 6.
Claim 6
Dependent Claim
60 words
A stable, non-radioactive carrier solution having a pH between about 3 and about 7, said solution being suitable for bone marrow scanning when autoclaved and labeled with 99m Tc, said solution comprising sodium phytate; stannous ion chelated with oxalate, and an aqueous solution, the ratio by weight of said phytate to said chelate being at least about 1 to 1.
Claim 7
Dependent Claim
60 words
A stable, non-radioactive carrier solution having a pH between about 3 and about 7, said solution being suitable for bone marrow scanning when autoclaved and labeled with 99m Tc, said solution comprising sodium phytate; stannous ion chelated with oxalate, and an aqueous solution, the ratio by weight of said phytate to said chelate being at least about 1 to 1.
Claim 8
Independent Claim
109 words
A method of preparing a stable, radioactive carrier suitable for liver scanning when labeled with 99m Tc and suitable for bone marrow scanning when autoclaved and then labeled with 99m Tc, said method comprising; dissolving sodium phytate in an aqueous solution free of entrained oxygen to form a first solution; dissolving stannous oxalate in a non-oxidizing acid to form a second solution, the ratio by weight of said first amount to said second amount being at least about 1 to 1; contracting said first solution with said second solution to form a third solution; and adjusting the pH of said third solution to between about 4 and about 7.
Claim 9
Independent Claim
109 words
A method of preparing a stable, radioactive carrier suitable for liver scanning when labeled with 99m Tc and suitable for bone marrow scanning when autoclaved and then labeled with 99m Tc, said method comprising; dissolving sodium phytate in an aqueous solution free of entrained oxygen to form a first solution; dissolving stannous oxalate in a non-oxidizing acid to form a second solution, the ratio by weight of said first amount to said second amount being at least about 1 to 1; contracting said first solution with said second solution to form a third solution; and adjusting the pH of said third solution to between about 4 and about 7.
Claim 10
Dependent Claim
34 words
A method as defined in claim 6 wherein said non-oxidizing acid is selected from the group consisting of hydrochloric, acetic, sulfuric and phosphoric acid and said ratio is at least about 3 to 1.
Claim 11
Dependent Claim
17 words
A method as defined in claim 7 wherein said ratio is at least about 13 to 1.
Claim 12
Dependent Claim
33 words
A method as defined in claim 7 wherein said ratio is between about 3 to 1 and about 20 to 1, said pH is about 6 and said non-oxidizing acid is hydrochloric acid.
Claim 13
Dependent Claim
20 words
A method as defined in claim 6 further including: adjusting the concentration of said third solution to a predetermined concentration.
Claim 14
Dependent Claim
24 words
A method as defined in claim 10 further including: lyophilizing said third solution at a temperature below about 30° C to form a solid.
Claim 15
Dependent Claim
25 words
A method as defined in claim 11 wherein when said third solution is lyophilized at a temperature between about 30° C and about -10° C.
Claim 16
Dependent Claim
17 words
A method as defined in claim 12 further including: redissolving said lyophilized solid in an aqueous solution.
Claim 17
Dependent Claim
52 words
A method as defined in claim 6 further including: autoclaving said third solution at a temperature of from about 240° F to about 290° F, for a time period between about 1 hour and about 6 hours and at a pressure between about 10 to about 43 psi to form a colloid.
Claim 18
Dependent Claim
31 words
A method as defined in claim 14 wherein said autoclave temperature is about 270° F, said autoclave time period is about 2 hours and said autoclave pressure is about 28 psi.
Claim 19
Dependent Claim
52 words
A method as defined in claim 13 further including: autoclaving said redissolved solution at a temperature of from about 240° F to about 290° F, for a time period between about 1 hour and about 6 hours and at a pressure between about 10 to about 43 psi to form a colloid.
Claim 20
Dependent Claim
31 words
A method as defined in claim 16 wherein said autoclave temperature is about 270° F, said autoclave time period is about 2 hours and said autoclave pressure is about 28 psi.
Claim 21
Dependent Claim
36 words
A method as defined in claim 6 wherein said third solution is contacted with a sufficient amount of a saline solution of Na 99m TcO 4 to form a 99mTc-labeled radiodiagnostic agent suitable for liver scanning.
Claim 22
Dependent Claim
37 words
A method as defined in claim 13 wherein said redissolved solution is contacted with a sufficient amount of a saline solution of Na 99m TcO 4 to form a 99m Tc-labeled radiodiagnostic agent suitable for liver scanning.
Claim 23
Dependent Claim
38 words
A method as defined in claim 14 wherein said autoclaved colloid is contacted with a sufficient amount of a saline solution of Na 99m TcO 4 to form a 99m Tc-labeled radiodiagnostic agent suitable for bone marrow scanning.
Claim 24
Dependent Claim
39 words
A method as defined in claim 16 wherein said autoclaved colloid is contacted with a sufficient amount of a saline solution of Na 99m TcO 4 to form a 99 m Tc-labeled radiodiagnostic agent suitable for bone marrow scanning.
Claim 25
Dependent Claim
54 words
A radiodiagnostic agent suitable for liver scanning and having a pH between about 3 and about 7, said agent comprising sodium phytate; stannous ion chelated with oxalate, and a saline solution of Na 99m TcO 4 , the ratio by weight of said phytate to said chelate being at least about 1 to 1.
Claim 26
Dependent Claim
54 words
A radiodiagnostic agent suitable for liver scanning and having a pH between about 3 and about 7, said agent comprising sodium phytate; stannous ion chelated with oxalate, and a saline solution of Na 99m TcO 4 , the ratio by weight of said phytate to said chelate being at least about 1 to 1.
Claim 27
Dependent Claim
60 words
A stable, non-radioactive colloid suitable for bone marrow scanning when labeled with 99m Tc, said colloid comprising an autoclaved mixture of sodium phytate; stannous ion chelated with oxalate, and an aqueous solution, the ratio by weight of said phytate to said chelate being at least about 1 to 1, said colloid having a particle size less than about 1 micron.
Claim 28
Dependent Claim
60 words
A stable, non-radioactive colloid suitable for bone marrow scanning when labeled with 99m Tc, said colloid comprising an autoclaved mixture of sodium phytate; stannous ion chelated with oxalate, and an aqueous solution, the ratio by weight of said phytate to said chelate being at least about 1 to 1, said colloid having a particle size less than about 1 micron.
Claim 29
Dependent Claim
66 words
A radiodiagnostic colloid suitable for bone marrow scanning and having a pH between about 3 and about 7, said colloid comprising sodium phytate; stannous ion chelated with oxalate, and a saline solution of Na 99m TcO 4 , the ratio by weight of said phytate to said chelate being at least about 1 to 1, said colloid having a particle size less than about 1 micron.
Claim 30
Dependent Claim
66 words
A radiodiagnostic colloid suitable for bone marrow scanning and having a pH between about 3 and about 7, said colloid comprising sodium phytate; stannous ion chelated with oxalate, and a saline solution of Na 99m TcO 4 , the ratio by weight of said phytate to said chelate being at least about 1 to 1, said colloid having a particle size less than about 1 micron.
References Cited (Backward Citations)
US3875299A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-15 | 1981-02-14 | 1981-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-15 | 1985-02-14 | 1985-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-15 | 1989-02-14 | 1989-08-16 | $7700.00 | Window Closed / Lapsed |