Patent US4041040A successfully refreshed from Google Patents.
US4041040A
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US
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Ecgonine derivative
Assignee: Hoffmann La Roche Inc
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Filing: 1976-09-22
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Granted: 1977-08-09
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Expires: 1996-09-22
Abstract
Abstract A novel derivative of ecgonine is described. This compound, 4-hyroxy-benzoyl ecgonine, is useful as a substrate for iodination with a radioactive isotope of iodine such as 125 I. The resulting radiolabeled compound is useful in a radioimmunoassay for benzoyl ecgonine.
Inventors
- 👤 James Gordon Christenson
- 👤 Harvey Gurien
- 👤 Sidney Teitel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 07:36
CPC Classifications
C; C07; C07D; C07D451/00; C07D451/02; C07D451/04; C07D451/06; C07D451/12; Y; Y10; Y10S; Y10S436/00; Y10S436/804; Y10S436/815; Y10S436/816
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
11 words
Ecgonine methyl ester (p-lower alkanoyloxy) benzoate and acid addition salts thereof.
Claim 2
Dependent Claim
11 words
Ecgonine methyl ester (p-lower alkanoyloxy) benzoate and acid addition salts thereof.
Claim 3
Dependent Claim
13 words
The compound of claim 1 which is ecgonine methyl ester (p-acetoxy) benzoate hydrochloride.
Claim 4
Dependent Claim
7 words
4-Hydroxybenzoyl ecgonine and acid addition salts thereof.
Claim 5
Dependent Claim
7 words
4-Hydroxybenzoyl ecgonine and acid addition salts thereof.
Claim 6
Dependent Claim
30 words
A process for the preparation of 4-hydroxybenzoyl ecgonine, which process involves selectively hydrolyzing an ecgonine methyl ester (p-lower alkanoyloxy) benzoate or an acid addition salt thereof in water at reflux.
Claim 7
Dependent Claim
30 words
A process for the preparation of 4-hydroxybenzoyl ecgonine, which process involves selectively hydrolyzing an ecgonine methyl ester (p-lower alkanoyloxy) benzoate or an acid addition salt thereof in water at reflux.
Claim 8
Dependent Claim
19 words
The process of claim 4 wherein said ecgonine methyl ester (p-lower alkanoyloxy) benzoate is ecgonine methyl ester (p-acetoxy) benzoate.
References Cited (Backward Citations)
US3498989A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-08 | 1981-02-07 | 1981-08-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-08 | 1985-02-07 | 1985-08-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-08 | 1989-02-07 | 1989-08-09 | $7700.00 | Window Closed / Lapsed |