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US4039672A
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N-(1'-allypyrrolidinyl 2'-methyl) 2-methoxy 4,5-azimido benzamide and its pharmaceutically acceptable salts
Assignee: Societe dEtudes Scientifiques et Industrielles de lIle de France SA
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Filing: 1975-03-03
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Granted: 1977-08-02
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Expires: 1995-03-03
Abstract
Abstract The azimido benzamide of this invention and its pharmaceutically acceptable salts have an unusually and unexpectedly high therapeutic index and low toxicity in the treatment of emesis in mammals. Pharmacological testing demonstrated the superior efficacy of the compound of this invention over known, similar compounds.
Inventors
- 👤 Gerard Bulteau
- 👤 Jacques Acher
- 👤 Claude Collignon
- 👤 Jean-Claude Monier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:08
CPC Classifications
C; C07; C07D; C07D403/00; C07D403/02; C07D403/12
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
22 words
A compound selected from the class consisting of N-(1'-allylpyrrolidinyl-2'-methyl)-2-methoxy-4,5-azimidobenzamide, pharmaceutically acceptable acid addition salts thereof and pharmaceutically acceptable quaternary ammonium salts thereof.
Claim 2
Dependent Claim
22 words
A compound selected from the class consisting of N-(1'-allylpyrrolidinyl-2'-methyl)-2-methoxy-4,5-azimidobenzamide, pharmaceutically acceptable acid addition salts thereof and pharmaceutically acceptable quaternary ammonium salts thereof.
Claim 3
Dependent Claim
8 words
A compound of claim 1 which is N-(1'-allylpyrrolidinyl-2'-methyl)-2-methoxy-4,5-azimidobenzamide.
Claim 4
Dependent Claim
18 words
A compound of claim 1 which is a pharmaceutically acceptable acid addition salt of N-(1'-allylpyrrolidinyl 2'-methyl) 2-methoxy 4,5-azimidobenzamide.
Claim 5
Dependent Claim
24 words
A method of protecting a mammal against emesis which comprises administering to said mammal an anti-emesis effective amount of a compound of claim 1.
Claim 6
Dependent Claim
15 words
A compound of claim 1 which is a pharmaceutically acceptable quaternary ammonium salt of N-(1'-allylpyrrolidinyl-2'-methyl)-2-methoxy-4,5-azimidobenzamide.
References Cited (Backward Citations)
US3839330A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-01 | 1981-01-31 | 1981-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-01 | 1985-01-31 | 1985-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-01 | 1989-01-31 | 1989-08-02 | $7700.00 | Window Closed / Lapsed |