US4039664A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Topical griseofulvin composition and method
Assignee: Whitby Research Inc
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Filing: 1975-04-11
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Granted: 1977-08-02
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Expires: 1995-04-11
Abstract
Abstract There is disclosed a composition and method for topically administering griseofulvin to a human or animal in a manner such that a high degree of epidermal, especially stratum corneum, retention of griseofulvin is attained, by contacting the skin of a human or animal with an effective amount of a therapeutic composition containing griseofulvin in a vehicle system comprising 2-pyrrolidone and N-methyl-2-pyrrolidone in a ratio ranging between about 1:4 and about 4:1, said composition containing at least about 10% by weight of said vehicle system.
Inventors
- 👤 Richard B. Stoughton
- 👤 Richard L. Harris
- 👤 Frank J. Dea
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 11:04
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/22; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61K8/445; A61K8/49; A61K8/4906; A61K8/4913; A61K8/63; A61K9/00; A61K9/0012; A61K9/0014; A61Q; A61Q17/00; A61Q17/02; A61Q17/04; A61Q5/00; A61Q5/10; Y; Y10; Y10S; Y10S424/00; Y10S424/05
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
57 words
A composition useful in the topical treatment of fungal infections of the skin and nails comprising an effective anti-fungal amount of griseofulvin, together with a vehicle system comprising a mixture of 2-pyrrolidone and N-methyl-2-pyrrolidone in a ratio ranging between about 1:4 and about 4:1, said composition containing at least about 10% by weight of said vehicle system.
Claim 2
Dependent Claim
57 words
A composition useful in the topical treatment of fungal infections of the skin and nails comprising an effective anti-fungal amount of griseofulvin, together with a vehicle system comprising a mixture of 2-pyrrolidone and N-methyl-2-pyrrolidone in a ratio ranging between about 1:4 and about 4:1, said composition containing at least about 10% by weight of said vehicle system.
Claim 3
Dependent Claim
23 words
The composition of claim 1 containing about 10 to about 40% by weight 2-pyrrolidone and about 10 to about 40% by weight N-methyl-2-pyrrolidone.
Claim 4
Dependent Claim
17 words
The composition of claim 1 containing about 30% by weight 2-pyrrolidone and about 20% by weight N-methyl-2-pyrrolidone.
Claim 5
Dependent Claim
14 words
The composition of claim 1 containing about 50% of an additional topical pharmaceutical carrier.
Claim 6
Dependent Claim
16 words
The composition of claim 4 wherein the topical pharmaceutical carrier comprises ethyl alcohol or isopropyl alcohol.
Claim 7
Dependent Claim
19 words
The composition of claim 1 wherein effective anti-fungal amount of griseofulvin is about 0.1 to about 10% by weight.
Claim 8
Dependent Claim
29 words
A composition comprising about 1% griseofulvin together with about 30% by weight 2-pyrrolidone, about 20% by weight N-methyl-2-pyrrolidone and about 49% by weight of an additional topical pharmaceutical carrier.
Claim 9
Dependent Claim
29 words
A composition comprising about 1% griseofulvin together with about 30% by weight 2-pyrrolidone, about 20% by weight N-methyl-2-pyrrolidone and about 49% by weight of an additional topical pharmaceutical carrier.
Claim 10
Independent Claim
73 words
A method for therapeutically treating fungal infections of the skin and nails in humans or animals comprising contacting human or animal skin or nails with an effective amount of a therapeutic composition containing about 0.1 to about 10% by weight griseofulvin in a vehicle system comprising a mixture of 2-pyrrolidone and N-methyl-2-pyrrolidone in a ratio ranging between about 1:4 and about 4:1, said composition containing at least about 10% of said vehicle system.
Claim 11
Independent Claim
73 words
A method for therapeutically treating fungal infections of the skin and nails in humans or animals comprising contacting human or animal skin or nails with an effective amount of a therapeutic composition containing about 0.1 to about 10% by weight griseofulvin in a vehicle system comprising a mixture of 2-pyrrolidone and N-methyl-2-pyrrolidone in a ratio ranging between about 1:4 and about 4:1, said composition containing at least about 10% of said vehicle system.
Claim 12
Dependent Claim
27 words
The method of claim 8 wherein the vehicle system comprises about 10 to about 40% by weight 2-pyrrolidone and about 10 to about 40% by weight N-methyl-2-pyrrolidone.
Claim 13
Dependent Claim
21 words
The method of claim 8 wherein the vehicle system comprises about 30% by weight 2-pyrrolidone and about 20% by weight N-methyl-2-pyrrolidone.
Claim 14
Dependent Claim
17 words
The method of claim 8 wherein the composition contains about 50% of an additional topical pharmaceutical carrier.
Claim 15
Dependent Claim
16 words
The method of claim 11 wherein the topical pharmaceutical carrier comprises ethyl alcohol or isopropyl alcohol.
Claim 16
Independent Claim
59 words
A method for therapeutically treating fungal infections of the skin and nails in humans and animals comprising contacting said human or animal skin or nails with an effective amount of a composition comprising about 1% by weight griseofulvin, about 30% by weight 2-pyrrolidone, about 20% by weight N-methyl-2-pyrrolidone and about 49% by weight of an additional topical pharmaceutical carrier.
Claim 17
Independent Claim
59 words
A method for therapeutically treating fungal infections of the skin and nails in humans and animals comprising contacting said human or animal skin or nails with an effective amount of a composition comprising about 1% by weight griseofulvin, about 30% by weight 2-pyrrolidone, about 20% by weight N-methyl-2-pyrrolidone and about 49% by weight of an additional topical pharmaceutical carrier.
References Cited (Backward Citations)
CA871678A
Cited
GB794482A
Cited
FR2001768A1
Cited
US3634586A
Cited
US3636194A
Cited
US3932653A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-01 | 1981-01-31 | 1981-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-01 | 1985-01-31 | 1985-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-01 | 1989-01-31 | 1989-08-02 | $7700.00 | Window Closed / Lapsed |