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US4039663A
Expired / Lapsed
US
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Daunomycins, process for their uses and intermediates
Assignee: Pfizer Italia SRL
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Filing: 1975-03-19
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Granted: 1977-08-02
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Expires: 1995-03-19
Abstract
Abstract The known antibiotic daunomycin, and the novel compounds daunomycin-β-anomer and 4'-epidaunomycin (both α- and β-anomers) are prepared by condensing daunomycinone with reactive novel intermediates which are 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-α-L-lyxo (or arabino) hexopyranoses.
Inventors
- 👤 Federico Arcamone
- 👤 Aurelio Di Marco
- 👤 Sergio Penco
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 23:48
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/02; C07H13/04; C07H15/00; C07H15/20; C07H15/24; C07H15/252
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
25 words
A mixture of the α- and β-anomers of 4'epidaunomycin wherein the α-anomer comprises about 70% by weight and the β-anomer comprises about 30% by weight.
Claim 2
Dependent Claim
25 words
A mixture of the α- and β-anomers of 4'epidaunomycin wherein the α-anomer comprises about 70% by weight and the β-anomer comprises about 30% by weight.
Claim 3
Dependent Claim
11 words
A 2,3,6-trideoxy-1-trifluoroacetoxy-3-trifluoroacetamido-4-trifluoroacetoxy-L-hexose selected from the group consisting of 2,3,6-trideoxy-1-trifluoroacetoxy-3-trifluoroacetamido-4-trifluoroacetoxy-L-lyxohexopyranose and 2,3,6-trideoxy-1-trifluoroacetoxy-3-trifluoroacetamido-4-trifluoroacetoxy-L-arabinohexopyranose.
Claim 4
Dependent Claim
11 words
A 2,3,6-trideoxy-1-trifluoroacetoxy-3-trifluoroacetamido-4-trifluoroacetoxy-L-hexose selected from the group consisting of 2,3,6-trideoxy-1-trifluoroacetoxy-3-trifluoroacetamido-4-trifluoroacetoxy-L-lyxohexopyranose and 2,3,6-trideoxy-1-trifluoroacetoxy-3-trifluoroacetamido-4-trifluoroacetoxy-L-arabinohexopyranose.
Claim 5
Dependent Claim
9 words
A compound according to claim 2 which is 2,3,6-trideoxy-1-trifluoroacetoxy-3-trifluoroacetamido-4-trifluoroacetoxy-L-lyxohexopyranose.
Claim 6
Dependent Claim
9 words
A compound according to claim 2 which is 2,3,6-trideoxy-1-trifluoroacetoxy-3-trifluoroacetamido-4-trifluoroacetoxy-L-arabinohexopyranose.
Claim 7
Dependent Claim
11 words
A 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-L-hexose selected from the group consisting of 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-α-L-lyxohexopyranose and 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-α-L-arabinohexopyranose.
Claim 8
Dependent Claim
11 words
A 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-L-hexose selected from the group consisting of 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-α-L-lyxohexopyranose and 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-α-L-arabinohexopyranose.
Claim 9
Dependent Claim
9 words
A compound according to claim 5 which is 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-α-L-lyxohexopyranose.
Claim 10
Dependent Claim
9 words
A compound according to claim 5 which is 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-α-L-arabinohexopyranose.
Claim 11
Dependent Claim
58 words
A method of inhibiting the growth of a tumor selected from the group consisting of Moloney Sarcoma Virus, Sacroma 180 Ascites and gross transplantable leukemia which comprises administering to a host afflicted with said tumor an amount of the mixture of claim 1 sufficient to inhibit the growth of said tumor, together with an inert, pharmaceutically acceptable carrier.
Claim 12
Dependent Claim
12 words
A method according to claim 8 wherein the compound is administered intravenously.
References Cited (Backward Citations)
US2949449A
Cited
US3356674A
Cited
US3524844A
Cited
US3427300A
Cited
US3501456A
Cited
US3803124A
Cited
US3686163A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-01 | 1981-01-31 | 1981-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-01 | 1985-01-31 | 1985-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-01 | 1989-01-31 | 1989-08-02 | $7700.00 | Window Closed / Lapsed |